U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Rbm3 RNA binding motif protein 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114488, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Rbm3provided by RGD
Official Full Name
RNA binding motif protein 3provided by RGD
Primary source
RGD:620145
See related
Ensembl:ENSRNOG00000005387 AllianceGenome:RGD:620145
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable ribosomal large subunit binding activity. Involved in positive regulation of translation. Located in cytoplasm; dendrite; and nucleus. Orthologous to human RBM3 (RNA binding motif protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 1338.6), Spleen (RPKM 1167.2) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Rbm3 in Genome Data Viewer
Location:
Xq12
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (17020863..17024341)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (14348909..14352387)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (15098880..15102344)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene EBP, cholestenol delta-isomerase Neighboring gene TBC1 domain family, member 25 Neighboring gene WD repeat domain 13 Neighboring gene U6 spliceosomal RNA Neighboring gene WASP actin nucleation promoting factor

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons. Sertel SM, et al. J Neurosci, 2021 Feb 10. PMID 33310754, Free PMC Article
  2. Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons. Jackson TC, et al. Neuroscience, 2015 Oct 1. PMID 26265550, Free PMC Article
  3. Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats. Cui Z, et al. J Mol Neurosci, 2014. PMID 24668366
  4. Spatiotemporal pattern of RNA-binding motif protein 3 expression after spinal cord injury in rats. Zhao W, et al. Cell Mol Neurobiol, 2014 May. PMID 24570111
  5. Developmentally regulated expression of the cold-inducible RNA-binding motif protein 3 in euthermic rat brain. Pilotte J, et al. Brain Res, 2009 Mar 3. PMID 19150436

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons.
    Title: The mRNA-Binding Protein RBM3 Regulates Activity Patterns and Local Synaptic Translation in Cultured Hippocampal Neurons.
  2. Overexpression of RBM3 also attenuated muscle atrophy in rat soleus muscle undergoing disuse atrophy. These findings provide direct evidence for a novel role of RBM3 in inducing hypertrophy as well as attenuating atrophy.
    Title: Cold shock protein RBM3 attenuates atrophy and induces hypertrophy in skeletal muscle.
  3. This study showed that a 1 degrees C reduction in temperature can induce pleiotropic biochemical changes by upregulating global protein synthesis in neurons.
    Title: Cold stress protein RBM3 responds to temperature change in an ultra-sensitive manner in young neurons.
  4. RBM3 expression was increased in astrocytes after spinal cord injury. RBM3 regulated proliferation of astrocytes in vitro.
    Title: Spatiotemporal profile and essential role of RBM3 expression after spinal cord injury in adult rats.
  5. RBM3 might play important roles in central nervous system pathophysiology after spinal cord injury
    Title: Spatiotemporal pattern of RNA-binding motif protein 3 expression after spinal cord injury in rats.
  6. These results indicate that expression of RBM3 is dynamically regulated in the developing brain and suggest that it contributes to translation-dependent processes underlying proliferation, differentiation, and plasticity.
    Title: Developmentally regulated expression of the cold-inducible RNA-binding motif protein 3 in euthermic rat brain.
  7. Aa cold-shock response may be part of a compensatory mechanism in muscles undergoing atrophy to preserve remaining muscle mass. RBM3, which was induced most highly in atrophic muscle from old rats, may be a therapeutic target to prevent muscle loss.
    Title: Identification of cold-shock protein RBM3 as a possible regulator of skeletal muscle size through expression profiling.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC105811

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosomal large subunit binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosomal large subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within miRNA processing ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of translation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of translation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within response to cold ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within translation ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
part_of large ribosomal subunit IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
part_of spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
RNA-binding protein 3
Names
RNA binding motif (RNP1, RRM) protein 3
putative RNA-binding protein 3

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053696.1 → NP_446148.1  RNA-binding protein 3

    See identical proteins and their annotated locations for NP_446148.1

    Status: VALIDATED

    Source sequence(s)
    AF355190, CA340698, DN933310, DY319481
    UniProtKB/Swiss-Prot
    Q925G0
    UniProtKB/TrEMBL
    A6KP47, G3V6P6
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    17020863..17024341
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256694.3 → XP_006256756.1  RNA-binding protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006256756.1

    UniProtKB/Swiss-Prot
    Q925G0
    UniProtKB/TrEMBL
    A6KP47, G3V6P6
    Related
    ENSRNOP00000007367.4
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

  2. XM_006256695.3 → XP_006256757.1  RNA-binding protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006256757.1

    UniProtKB/Swiss-Prot
    Q925G0
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

  3. XM_006256696.3 → XP_006256758.1  RNA-binding protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006256758.1

    UniProtKB/Swiss-Prot
    Q925G0
    Conserved Domains (1) summary
    cd12449
    Location:6 → 85
    RRM_CIRBP_RBM3; RNA recognition motif (RRM) found in cold inducible RNA binding protein (CIRBP), RNA binding motif protein 3 (RBM3) and similar proteins

  4. XM_063279735.1 → XP_063135805.1  RNA-binding protein 3 isoform X3

  5. XM_063279736.1 → XP_063135806.1  RNA-binding protein 3 isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q925G0.2 GenPept UniProtKB/Swiss-Prot:Q925G0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous