Mllt3 MLLT3, super elongation complex subunit [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mllt3provided by RGD
Official Full Name: MLLT3, super elongation complex subunitprovided by RGD
Primary source: RGD:620940
See related: Ensembl:ENSRNOG00000011280 AllianceGenome:RGD:620940
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Af9; Af-9
Summary: Predicted to enable chromatin binding activity and lysine-acetylated histone binding activity. Predicted to be involved in several processes, including hematopoietic stem cell differentiation; positive regulation of transcription, DNA-templated; and regulation of stem cell division. Predicted to act upstream of or within gene expression; regionalization; and regulation of Wnt signaling pathway. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of transcription elongation factor complex. Orthologous to human MLLT3 (MLLT3 super elongation complex subunit). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Muscle (RPKM 157.5), Thymus (RPKM 100.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (107305008..107561352, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (102259075..102515447, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (106103498..106202559, complement)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

BE111905 (e-PCR)
- UniSTS:245811

RH139198 (e-PCR)
- UniSTS:221284

RH144610 (e-PCR)
- UniSTS:233855

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables chromatin binding	ISO Inferred from Sequence Orthology more info
enables histone binding	ISO Inferred from Sequence Orthology more info
enables lysine-acetylated histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables lysine-acetylated histone binding	ISO Inferred from Sequence Orthology more info
enables modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables molecular adaptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within anterior/posterior pattern specification	ISO Inferred from Sequence Orthology more info
involved_in biological_process	ND No biological Data available more info
acts_upstream_of_or_within gene expression	ISO Inferred from Sequence Orthology more info
involved_in hematopoietic stem cell differentiation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of Wnt signaling pathway, planar cell polarity pathway	ISO Inferred from Sequence Orthology more info
involved_in regulation of chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of stem cell division	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within segment specification	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription elongation factor complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription elongation factor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein AF-9

Names: myeloid/lymphoid or mixed lineage-leukemia translocation to 3 homolog; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 3; myeloid/lymphoid or mixed-lineage leukemia,translocated to, 3 (trithorax homolog, Drosophila); myeloid/lymphoid or mixed-lineage leukemia; translocated to, 3; translocated to, 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053718.4 → NP_446170.2 protein AF-9

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2QC34, A0A8I5ZRB6

Related

ENSRNOP00000080897.1, ENSRNOT00000114354.1

Conserved Domains (2) summary

cd16906
Location:9 → 137

YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins

pfam17793
Location:504 → 564

AHD; ANC1 homology domain (AHD)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

107305008..107561352 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039109122.2 → XP_038965050.1 protein AF-9 isoform X1

UniProtKB/TrEMBL

A0A0G2QC34, A0A8I6A8N3

Related

ENSRNOP00000087456.1

Conserved Domains (2) summary

cd16906
Location:6 → 134

YEATS_AF-9_like; YEATS domain found in ENL and AF-9-like proteins

pfam17793
Location:501 → 561

AHD; ANC1 homology domain (AHD)
XM_039109124.2 → XP_038965052.1 protein AF-9 isoform X2

Conserved Domains (1) summary

pfam17793
Location:97 → 157

AHD; ANC1 homology domain (AHD)
XM_039109123.2 → XP_038965051.1 protein AF-9 isoform X2

Conserved Domains (1) summary

pfam17793
Location:97 → 157

AHD; ANC1 homology domain (AHD)