Zp3 zona pellucida glycoprotein 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Zp3provided by RGD
Official Full Name: zona pellucida glycoprotein 3provided by RGD
Primary source: RGD:620606
See related: Ensembl:ENSRNOG00000001434 AllianceGenome:RGD:620606
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Zp-3
Summary: Predicted to enable several functions, including acrosin binding activity; identical protein binding activity; and receptor ligand activity. Predicted to be a structural constituent of egg coat. Predicted to be involved in several processes, including oogenesis; positive regulation of immune response; and regulation of gene expression. Predicted to be located in several cellular components, including collagen-containing extracellular matrix; egg coat; and extracellular space. Predicted to be active in extracellular matrix. Orthologous to several human genes including ZP3 (zona pellucida glycoprotein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Uterus (RPKM 3.6), Thymus (RPKM 1.5) and 2 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 12q12

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	12	NC_086030.1 (26327161..26334126, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	12	NC_051347.1 (20690547..20697513, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	12	NC_005111.4 (23735225..23752734, complement)

Chromosome 12 - NC_086030.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in ratsdagger.
Title: Mutant Zp1 impedes incorporation of ZP3 and ZP4 in the zona pellucida, resulting in zona absence and female infertility in rats†.

Submit: New GeneRIF Correction

General gene information

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Markers

Zp3 (e-PCR), detects polymorphism
- UniSTS:144846

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables acrosin binding	IBA Inferred from Biological aspect of Ancestor more info
enables acrosin binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables receptor ligand activity	ISS Inferred from Sequence or Structural Similarity more info
enables structural constituent of egg coat	IEA Inferred from Electronic Annotation more info
enables structural constituent of egg coat	ISO Inferred from Sequence Orthology more info
enables structural constituent of egg coat	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IBA Inferred from Biological aspect of Ancestor more info
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in binding of sperm to zona pellucida	ISS Inferred from Sequence or Structural Similarity more info
involved_in blastocyst formation	IEA Inferred from Electronic Annotation more info
involved_in blastocyst formation	ISO Inferred from Sequence Orthology more info
involved_in blastocyst formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in egg coat formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in egg coat formation	IEA Inferred from Electronic Annotation more info
involved_in egg coat formation	ISO Inferred from Sequence Orthology more info
involved_in egg coat formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in humoral immune response mediated by circulating immunoglobulin	IEA Inferred from Electronic Annotation more info
involved_in humoral immune response mediated by circulating immunoglobulin	ISO Inferred from Sequence Orthology more info
involved_in humoral immune response mediated by circulating immunoglobulin	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of binding of sperm to zona pellucida	ISS Inferred from Sequence or Structural Similarity more info
involved_in oocyte development	IEA Inferred from Electronic Annotation more info
involved_in oocyte development	ISO Inferred from Sequence Orthology more info
involved_in oocyte development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of T cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of acrosomal vesicle exocytosis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acrosomal vesicle exocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of acrosome reaction	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of acrosome reaction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of acrosome reaction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of acrosome reaction	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of antral ovarian follicle growth	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of antral ovarian follicle growth	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of antral ovarian follicle growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of humoral immune response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of humoral immune response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-4 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-4 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-4 production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of leukocyte migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of leukocyte migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of leukocyte migration	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ovarian follicle development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ovarian follicle development	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ovarian follicle development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type IV hypersensitivity	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of type IV hypersensitivity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type IV hypersensitivity	ISS Inferred from Sequence or Structural Similarity more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in collagen-containing extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in collagen-containing extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	ISS Inferred from Sequence or Structural Similarity more info
located_in egg coat	IEA Inferred from Electronic Annotation more info
located_in egg coat	ISO Inferred from Sequence Orthology more info
located_in egg coat	ISS Inferred from Sequence or Structural Similarity more info
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: zona pellucida sperm-binding protein 3

Names: zona pellucida glycoprotein 3 (sperm receptor); zona pellucida glycoprotein ZP3; zona pellucida protein C

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053762.1 → NP_446214.1 zona pellucida sperm-binding protein 3 precursor

See identical proteins and their annotated locations for NP_446214.1

Status: PROVISIONAL

Source sequence(s)

D78482

UniProtKB/TrEMBL

A1L124, F7EZ23

Related

ENSRNOP00000001952.3, ENSRNOT00000001952.5

Conserved Domains (2) summary

smart00241
Location:45 → 304

ZP; Zona pellucida (ZP) domain

pfam00100
Location:183 → 302

Zona_pellucida; Zona pellucida-like domain