Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
HIV-1 gp120/CD4 interaction-induced NF-kappaB activation stimulates the hyperphosphorylation of IkappaB-alpha by IkappaB kinases (IKKs) |
PubMed
|
Nef
|
nef
|
HIV-1 Nef induces phosphorylation of CHUK (IKKalpha) |
PubMed
|
|
nef
|
HIV-1 Nef-induced strong activation of MAP kinases (p38/MAPK14, JNK/MAPK8, and ERK1/2) and NF-kappaB pathway (IKK alpha/beta) in M2-macrophages is mediated by TAK1 |
PubMed
|
|
nef
|
HIV-1 Nef induces phosphorylation of IKKalpha in M2-type macrophages |
PubMed
|
|
nef
|
The interaction of HIV-1 Nef with TRAF2, TRAF5, and TRAF6 proteins activates NF-kappaB, leading to the degradation of IkappaB-alpha and the increased phosphorylation of IKK-alpha and IKK-beta in monocyte-derived macrophages |
PubMed
|
|
nef
|
HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members |
PubMed
|
Tat
|
tat
|
HIV-1 Tat induces phosphorylation of CHUK (IKKalpha) in CRT-MG human astroglioma cells |
PubMed
|
|
tat
|
HIV-1 Tat induces phosphorylation of IKK-alpha/IKK-beta in human astroglioma cells |
PubMed
|
|
tat
|
HIV-1 Tat induces phosphorylation of IKK in HeLa-CD4-long terminal repeat (LTR)-beta-gal (MAGI) cells |
PubMed
|
|
tat
|
Tat stimulates NF-kappaB-inducing kinase IKKalpha translocation from the cytoplasm to the nucleus in monocytes, which leads to IKKalpha and CBP/p300 recruitment to the IL-10 promoter and histone H3 phosphorylation (Ser 10) and acetylation (Lys 14) |
PubMed
|
|
tat
|
Tat activates at least three signaling pathways concurrently, including NF-kappaB, PKC, ERK1/2 and p38 MAP kinases and IKKalpha pathways, to promote production of IL-10 |
PubMed
|
Vpr
|
vpr
|
HIV-1 Vpr requires CHUK (IKKa) or IKBKB (IKKb) to induce G2/M arrest in HeLa cells as shown through siRNA knockdown of CHUK (IKKa) or IKBKB (IKKb) |
PubMed
|
Go to the HIV-1, Human Interaction Database