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Wbp4 WW domain binding protein 4 [ Rattus norvegicus (Norway rat) ]

Gene ID: 114765, updated on 2-May-2024

Summary

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Official Symbol
Wbp4provided by RGD
Official Full Name
WW domain binding protein 4provided by RGD
Primary source
RGD:620033
See related
Ensembl:ENSRNOG00000011678 AllianceGenome:RGD:620033
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Fbp21
Summary
Predicted to enable RNA binding activity and proline-rich region binding activity. Predicted to be involved in mRNA cis splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2-type precatalytic spliceosome. Orthologous to human WBP4 (WW domain binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 103.1), Thymus (RPKM 101.1) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Wbp4 in Genome Data Viewer
Location:
15q12
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (61271774..61299740, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (54862700..54890668, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (61745989..61772516, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L15, pseudogene 1 Neighboring gene kelch repeat and BTB domain containing 6 Neighboring gene uncharacterized LOC134481995 Neighboring gene transfer RNA glutamic acid (anticodon UUC) 8 Neighboring gene microfibrillar-associated protein 1-like Neighboring gene E74 like ETS transcription factor 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Structure and function of the two tandem WW domains of the pre-mRNA splicing factor FBP21 (formin-binding protein 21). Huang X, et al. J Biol Chem, 2009 Sep 11. PMID 19592703, Free PMC Article
  2. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, et al. Proc Natl Acad Sci U S A, 1998 Sep 1. PMID 9724750, Free PMC Article
  3. A systematic analysis of 40 random genes in cultured vascular smooth muscle subtypes reveals a heterogeneity of gene expression and identifies the tight junction gene zonula occludens 2 as a marker of epithelioid "pup" smooth muscle cells and a participant in carotid neointimal formation. Adams LD, et al. Arterioscler Thromb Vasc Biol, 1999 Nov. PMID 10559001
  4. Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Bertram K, et al. Cell, 2017 Aug 10. PMID 28781166
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-rich region binding IEA
Inferred from Electronic Annotation
more info
  
enables proline-rich region binding ISO
Inferred from Sequence Orthology
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA cis splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA cis splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA cis splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome ISO
Inferred from Sequence Orthology
more info
  
involved_in mRNA splicing, via spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
part_of U2-type precatalytic spliceosome IEA
Inferred from Electronic Annotation
more info
  
part_of U2-type precatalytic spliceosome ISO
Inferred from Sequence Orthology
more info
  
part_of U2-type precatalytic spliceosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
WW domain-binding protein 4
Names
WBP-4
WW domain binding protein 4 (formin binding protein 21)
WW domain-containing-binding protein 4
formin-binding protein 21

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053766.2 → NP_446218.1  WW domain-binding protein 4

    See identical proteins and their annotated locations for NP_446218.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000015
    UniProtKB/Swiss-Prot
    Q5HZF2
    UniProtKB/TrEMBL
    A0A8L2Q7K4, A6HTZ4
    Related
    ENSRNOP00000076733.1, ENSRNOT00000111542.1
    Conserved Domains (2) summary
    pfam06220
    Location:8 → 42
    zf-U1; U1 zinc finger
    pfam00397
    Location:168 → 193
    WW; WW domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    61271774..61299740 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770840.4 → XP_008769062.1  WW domain-binding protein 4 isoform X1

    See identical proteins and their annotated locations for XP_008769062.1

    UniProtKB/TrEMBL
    A0A8I5Y9P1, A0A8L2Q7K4
    Related
    ENSRNOP00000077691.1
    Conserved Domains (2) summary
    cd00201
    Location:138 → 165
    WW; Two conserved tryptophans domain; also known as the WWP or rsp5 domain; around 40 amino acids; functions as an interaction module in a diverse set of signalling proteins; binds specific proline-rich sequences but at low affinities compared to other ...
    pfam00397
    Location:179 → 204
    WW; WW domain

  2. XM_063273906.1 → XP_063129976.1  WW domain-binding protein 4 isoform X4

  3. XM_063273904.1 → XP_063129974.1  WW domain-binding protein 4 isoform X2

  4. XM_063273905.1 → XP_063129975.1  WW domain-binding protein 4 isoform X3

  5. XM_063273907.1 → XP_063129977.1  WW domain-binding protein 4 isoform X5

RNA

  1. XR_010057795.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5HZF2.1 GenPept UniProtKB/Swiss-Prot:Q5HZF2

Gene LinkOut

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