U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Gale UDP-galactose-4-epimerase [ Rattus norvegicus (Norway rat) ]

Gene ID: 114860, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
Galeprovided by RGD
Official Full Name
UDP-galactose-4-epimeraseprovided by RGD
Primary source
RGD:621493
See related
Ensembl:ENSRNOG00000009712 AllianceGenome:RGD:621493
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable UDP-glucose 4-epimerase activity and protein homodimerization activity. Predicted to be involved in galactose catabolic process via UDP-galactose. Predicted to act upstream of or within galactose metabolic process. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in galactose epimerase deficiency. Orthologous to human GALE (UDP-galactose-4-epimerase). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 78.0), Lung (RPKM 45.0) and 9 other tissues See more
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See Gale in Genome Data Viewer
Location:
5q36
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (153477420..153481926)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (148193886..148198392)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (154310453..154314959)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene alpha-L-fucosidase 1 Neighboring gene 3-hydroxy-3-methylglutaryl-CoA lyase Neighboring gene lysophospholipase 2 Neighboring gene PITH domain containing 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. cDNA from rat cells with reconstitutive galactose-epimerase activity in E. coli. Zeschnigk M, et al. Nucleic Acids Res, 1990 Sep 11. PMID 2205840, Free PMC Article
  2. Functional analysis of disease-causing mutations in human UDP-galactose 4-epimerase. Timson DJ. FEBS J, 2005 Dec. PMID 16302980
  3. Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase. Schulz JM, et al. J Biol Chem, 2004 Jul 30. PMID 15175331
  4. Galactitol and galactonate accumulation in heart and skeletal muscle of mice with deficiency of galactose-1-phosphate uridyltransferase. Yager C, et al. Mol Genet Metab, 2004 Feb. PMID 14741191
  5. A massively parallel pipeline to clone DNA variants and examine molecular phenotypes of human disease mutations. Wei X, et al. PLoS Genet, 2014 Dec. PMID 25502805, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables UDP-N-acetylglucosamine 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 4-epimerase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables UDP-glucose 4-epimerase activity IEA
Inferred from Electronic Annotation
more info
  
enables UDP-glucose 4-epimerase activity ISO
Inferred from Sequence Orthology
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in galactose catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in galactose catabolic process via UDP-galactose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactose catabolic process via UDP-galactose IEA
Inferred from Electronic Annotation
more info
  
involved_in galactose catabolic process via UDP-galactose ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within galactose metabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
UDP-glucose 4-epimerase
Names
UDP-GalNAc 4-epimerase
UDP-GlcNAc 4-epimerase
UDP-N-acetylglucosamine 4-epimerase
UDP-galactosamine 4-epimerase
galactose-4-epimerase, UDP
galactowaldenase
NP_542961.2
XP_006239196.1
XP_038965061.1
XP_038965062.1
XP_063143133.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_080783.2 → NP_542961.2  UDP-glucose 4-epimerase

    See identical proteins and their annotated locations for NP_542961.2

    Status: PROVISIONAL

    Source sequence(s)
    BC097293
    UniProtKB/Swiss-Prot
    P18645
    UniProtKB/TrEMBL
    A0A9K3Y6V3, F7EKL8, Q4QRB0
    Conserved Domains (1) summary
    cd05247
    Location:4 → 338
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    153477420..153481926
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063287063.1 → XP_063143133.1  UDP-glucose 4-epimerase isoform X4

  2. XM_006239134.5 → XP_006239196.1  UDP-glucose 4-epimerase isoform X2

    See identical proteins and their annotated locations for XP_006239196.1

    UniProtKB/Swiss-Prot
    P18645
    UniProtKB/TrEMBL
    A0A9K3Y6V3, F7EKL8, Q4QRB0
    Related
    ENSRNOP00000013322.6
    Conserved Domains (1) summary
    cd05247
    Location:4 → 338
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  3. XM_039109133.2 → XP_038965061.1  UDP-glucose 4-epimerase isoform X1

    UniProtKB/Swiss-Prot
    P18645
    Conserved Domains (1) summary
    cd05247
    Location:37 → 371
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs

  4. XM_039109134.2 → XP_038965062.1  UDP-glucose 4-epimerase isoform X3

    Conserved Domains (1) summary
    cd05247
    Location:1 → 220
    UDP_G4E_1_SDR_e; UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18645.1 GenPept UniProtKB/Swiss-Prot:P18645

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous