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Pkia cAMP-dependent protein kinase inhibitor alpha [ Rattus norvegicus (Norway rat) ]

Gene ID: 114906, updated on 2-May-2024

Summary

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Official Symbol
Pkiaprovided by RGD
Official Full Name
cAMP-dependent protein kinase inhibitor alphaprovided by RGD
Primary source
RGD:621021
See related
Ensembl:ENSRNOG00000012095 AllianceGenome:RGD:621021
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cAMP-dependent protein kinase inhibitor activity and protein kinase A catalytic subunit binding activity. Predicted to be involved in negative regulation of cAMP-dependent protein kinase activity. Predicted to act upstream of or within negative regulation of nitrogen compound metabolic process; negative regulation of protein import into nucleus; and regulation of G2/M transition of mitotic cell cycle. Predicted to be active in cytoplasm and nucleus. Orthologous to human PKIA (cAMP-dependent protein kinase inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 1107.0), Heart (RPKM 683.8) and 3 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Pkia in Genome Data Viewer
Location:
2q23
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (96306181..96380959, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (94398869..94473638, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (96593185..96668222, complement)

Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORA17 Neighboring gene zinc finger, C2HC-type containing 1A Neighboring gene testis expressed 2, pseudogene 1 Neighboring gene RNA, U6 small nuclear 33

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. The alpha- and beta-isoforms of the inhibitor protein of the 3',5'-cyclic adenosine monophosphate-dependent protein kinase: characteristics and tissue- and developmental-specific expression. Van Patten SM, et al. Mol Endocrinol, 1992 Dec. PMID 1491692
  2. The expression and intracellular distribution of the heat-stable protein kinase inhibitor is cell cycle regulated. Wen W, et al. J Biol Chem, 1995 Feb 3. PMID 7836431
  3. Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase. Knighton DR, et al. Science, 1991 Jul 26. PMID 1862342
  4. Characterization of PKIgamma, a novel isoform of the protein kinase inhibitor of cAMP-dependent protein kinase. Collins SP, et al. J Biol Chem, 1997 Jul 18. PMID 9218452
  5. Glutamic acid 203 of the cAMP-dependent protein kinase catalytic subunit participates in the inhibition by two isoforms of the protein kinase inhibitor. Baude EJ, et al. J Biol Chem, 1994 Jan 21. PMID 7905001

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cAMP-dependent protein kinase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
enables cAMP-dependent protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein kinase A catalytic subunit binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cAMP-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cAMP/PKA signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of protein import into nucleus ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of G2/M transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cAMP-dependent protein kinase inhibitor alpha
Names
PKI-alpha
protein kinase (cAMP-dependent, catalytic) inhibitor alpha
protein kinase inhibitor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053772.2 → NP_446224.1  cAMP-dependent protein kinase inhibitor alpha

    See identical proteins and their annotated locations for NP_446224.1

    Status: VALIDATED

    Source sequence(s)
    FM055544, JAXUCZ010000002
    UniProtKB/Swiss-Prot
    P27776, P63249
    UniProtKB/TrEMBL
    A6IH81
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086020.1 Reference GRCr8

    Range
    96306181..96380959 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006232155.5 → XP_006232217.1  cAMP-dependent protein kinase inhibitor alpha isoform X1

    See identical proteins and their annotated locations for XP_006232217.1

    UniProtKB/Swiss-Prot
    P27776, P63249
    UniProtKB/TrEMBL
    A6IH81
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor

  2. XM_006232153.4 → XP_006232215.1  cAMP-dependent protein kinase inhibitor alpha isoform X2

    UniProtKB/TrEMBL
    A0A8L2Q830
    Related
    ENSRNOP00000016567.2, ENSRNOT00000016567.4
    Conserved Domains (1) summary
    pfam02827
    Location:44 → 112
    PKI; cAMP-dependent protein kinase inhibitor

  3. XM_008760857.3 → XP_008759079.2  cAMP-dependent protein kinase inhibitor alpha isoform X1

    UniProtKB/Swiss-Prot
    P27776, P63249
    UniProtKB/TrEMBL
    A6IH81
    Conserved Domains (1) summary
    pfam02827
    Location:2 → 70
    PKI; cAMP-dependent protein kinase inhibitor
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P63249.2 GenPept UniProtKB/Swiss-Prot:P63249

Gene LinkOut

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