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Adam17 a disintegrin and metallopeptidase domain 17 [ Mus musculus (house mouse) ]

Gene ID: 11491, updated on 4-Jan-2025

Summary

Official Symbol
Adam17provided by MGI
Official Full Name
a disintegrin and metallopeptidase domain 17provided by MGI
Primary source
MGI:MGI:1096335
See related
Ensembl:ENSMUSG00000052593 AllianceGenome:MGI:1096335
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tace; CD156b
Summary
This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero or fail to survive beyond one week of age. Alternative splicing results in multiple transcript variants encoding different isoforms, some of which may undergo similar processing. [provided by RefSeq, May 2016]
Expression
Ubiquitous expression in placenta adult (RPKM 12.8), CNS E11.5 (RPKM 9.9) and 28 other tissues See more
Orthologs
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Genomic context

See Adam17 in Genome Data Viewer
Location:
12 A1.3; 12 8.3 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (21373510..21423633, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (21323509..21373632, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Neighboring gene integrin beta 1 binding protein 1 Neighboring gene predicted gene, 25821 Neighboring gene cleavage and polyadenylation specificity factor 3 Neighboring gene STARR-positive B cell enhancer ABC_E1152 Neighboring gene isoamyl acetate-hydrolyzing esterase 1 homolog Neighboring gene predicted gene, 22766 Neighboring gene RIKEN cDNA F630048H11 gene Neighboring gene STARR-positive B cell enhancer mm9_chr12:21423322-21423623 Neighboring gene tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein theta Neighboring gene predicted gene 4419

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables Notch binding  
enables Notch binding  
enables PDZ domain binding  
enables SH3 domain binding  
enables cytokine binding  
enables endopeptidase activity PubMed 
enables endopeptidase activity  
enables integrin binding  
enables interleukin-6 receptor binding  
enables metal ion binding  
enables metallodipeptidase activity PubMed 
enables metalloendopeptidase activity  
enables metalloendopeptidase activity PubMed 
enables metalloendopeptidase activity PubMed 
enables metalloendopeptidase activity PubMed 
enables metalloendopeptidase activity  
enables metalloendopeptidase activity involved in amyloid precursor protein catabolic process  
enables metallopeptidase activity PubMed 
enables metallopeptidase activity PubMed 
enables metallopeptidase activity PubMed 
enables protein binding PubMed 
enables serine-type endopeptidase activity  
enables tumor necrosis factor binding  
Items 1 - 25 of 55
Process Evidence Code Pubs
involved_in B cell differentiation PubMed 
involved_in Notch receptor processing  
involved_in Notch receptor processing  
involved_in Notch signaling pathway  
involved_in Notch signaling pathway  
involved_in T cell differentiation in thymus PubMed 
involved_in amyloid precursor protein catabolic process  
involved_in cell adhesion  
involved_in cell adhesion mediated by integrin  
involved_in cell motility PubMed 
involved_in cellular response to high density lipoprotein particle stimulus  
involved_in commissural neuron axon guidance  
involved_in defense response to Gram-positive bacterium  
involved_in germinal center formation PubMed 
involved_in membrane protein ectodomain proteolysis  
acts_upstream_of_or_within membrane protein ectodomain proteolysis PubMed 
involved_in membrane protein ectodomain proteolysis PubMed 
acts_upstream_of_or_within membrane protein ectodomain proteolysis PubMed 
involved_in membrane protein ectodomain proteolysis PubMed 
involved_in membrane protein ectodomain proteolysis  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cold-induced thermogenesis PubMed 
acts_upstream_of_or_within negative regulation of neuron projection development PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway  
involved_in positive regulation of ERK1 and ERK2 cascade  
involved_in positive regulation of G1/S transition of mitotic cell cycle  
involved_in positive regulation of T cell chemotaxis  
involved_in positive regulation of apoptotic process  
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of cell growth  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of chemokine production  
involved_in positive regulation of cyclin-dependent protein serine/threonine kinase activity  
acts_upstream_of positive regulation of epidermal growth factor receptor signaling pathway PubMed 
involved_in positive regulation of epidermal growth factor receptor signaling pathway  
involved_in positive regulation of epidermal growth factor-activated receptor activity  
involved_in positive regulation of neuron projection development  
involved_in positive regulation of tumor necrosis factor production  
involved_in positive regulation of tumor necrosis factor-mediated signaling pathway  
involved_in positive regulation of vascular endothelial cell proliferation  
involved_in production of molecular mediator involved in inflammatory response PubMed 
involved_in protein processing  
involved_in proteolysis  
involved_in proteolysis  
acts_upstream_of_or_within regulation of axon regeneration PubMed 
involved_in regulation of mast cell apoptotic process PubMed 
acts_upstream_of_or_within regulation of neuron migration PubMed 
involved_in response to hypoxia  
involved_in response to lipopolysaccharide  
involved_in response to xenobiotic stimulus PubMed 
involved_in signal release  
involved_in signaling receptor ligand precursor processing PubMed 
involved_in signaling receptor ligand precursor processing PubMed 
involved_in spleen development PubMed 
Items 1 - 25 of 55
Component Evidence Code Pubs
located_in actin cytoskeleton  
located_in apical part of cell  
located_in apical plasma membrane  
located_in cell surface  
colocalizes_with cell-cell junction  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytosol  
located_in extracellular region  
colocalizes_with focal adhesion  
located_in membrane PubMed 
located_in membrane raft  
is_active_in plasma membrane  
is_active_in plasma membrane PubMed 
is_active_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane  
colocalizes_with ruffle membrane  

General protein information

Preferred Names
disintegrin and metalloproteinase domain-containing protein 17
Names
TNF-alpha convertase
TNF-alpha converting enzyme
NP_001264195.1
NP_001278800.1
NP_033745.4
XP_030102390.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277266.1NP_001264195.1  disintegrin and metalloproteinase domain-containing protein 17 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon compared to variant 1. The resulting isoform (2) contains an alternate internal 19 aa segment compared to isoform 1. This isoform (2) may undergo processing similar to isoform 1.
    Source sequence(s)
    AC140457, AC156032, BC094655
    Consensus CDS
    CCDS70376.1
    UniProtKB/TrEMBL
    E9PXU2, Q3UNK7
    Related
    ENSMUSP00000099087.4, ENSMUST00000101551.10
    Conserved Domains (4) summary
    smart00050
    Location:503578
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223496
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:49167
    Pep_M12B_propep; Reprolysin family propeptide
    pfam16698
    Location:600660
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
  2. NM_001291871.1NP_001278800.1  disintegrin and metalloproteinase domain-containing protein 17 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate 5' splice site, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded protein (isoform 4) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC140457, AC156032, AK142441, BC094655, BM248808
    UniProtKB/Swiss-Prot
    Q9Z0F8
    Conserved Domains (4) summary
    smart00050
    Location:246321
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:1239
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam13574
    Location:9222
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
    pfam16698
    Location:343403
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
  3. NM_009615.6NP_033745.4  disintegrin and metalloproteinase domain-containing protein 17 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_033745.4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (1).
    Source sequence(s)
    AC140457, AC156032, BC094655
    Consensus CDS
    CCDS25836.1
    UniProtKB/Swiss-Prot
    O88726, Q505A7, Q9R1U4, Q9Z0F8, Q9Z0K3
    UniProtKB/TrEMBL
    Q3UV09
    Related
    ENSMUSP00000067953.7, ENSMUST00000064536.13
    Conserved Domains (5) summary
    smart00050
    Location:484559
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:223477
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam01562
    Location:56166
    Pep_M12B_propep; Reprolysin family propeptide
    pfam13574
    Location:247460
    Reprolysin_2; Metallo-peptidase family M12B Reprolysin-like
    pfam16698
    Location:581641
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17

RNA

  1. NR_102380.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC140457, AC156032, BC094655
  2. NR_120376.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate 3' splice site, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC140457, AC156032, AK137693, AK142441, AK149614, BC094655, BM248808
    Related
    ENSMUST00000145118.8

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    21373510..21423633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030246530.2XP_030102390.1  disintegrin and metalloproteinase domain-containing protein 17 isoform X1

    UniProtKB/TrEMBL
    B7ZNJ0
    Conserved Domains (3) summary
    smart00050
    Location:321396
    DISIN; Homologues of snake disintegrins
    cd04270
    Location:60314
    ZnMc_TACE_like; Zinc-dependent metalloprotease; TACE_like subfamily. TACE, the tumor-necrosis factor-alpha converting enzyme, releases soluble TNF-alpha from transmembrane pro-TNF-alpha.
    pfam16698
    Location:418478
    ADAM17_MPD; Membrane-proximal domain, switch, for ADAM17
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