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Adra2a adrenergic receptor, alpha 2a [ Mus musculus (house mouse) ]

Gene ID: 11551, updated on 4-Jan-2025

Summary

Official Symbol
Adra2aprovided by MGI
Official Full Name
adrenergic receptor, alpha 2aprovided by MGI
Primary source
MGI:MGI:87934
See related
Ensembl:ENSMUSG00000033717 AllianceGenome:MGI:87934
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Adra-2; Adra-2a; alpha2A; alpha2-C10; alpha2A-AR; alpha(2A)AR
Summary
Enables alpha2-adrenergic receptor activity. Involved in negative regulation of insulin secretion and presynaptic modulation of chemical synaptic transmission. Acts upstream of or within G protein-coupled receptor signaling pathway and fear response. Is active in dopaminergic synapse. Is expressed in several structures, including central nervous system; genitourinary system; gut; limb segment; and sensory organ. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; attention deficit hyperactivity disorder; familial partial lipodystrophy; nicotine dependence; and type 2 diabetes mellitus. Orthologous to human ADRA2A (adrenoceptor alpha 2A). [provided by Alliance of Genome Resources, Jan 2025]
Orthologs
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Genomic context

See Adra2a in Genome Data Viewer
Location:
19 D2; 19 49.04 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (54033690..54037413)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (54045259..54048982)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 30990 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968181-53968334 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:53968382-53968491 Neighboring gene STARR-positive B cell enhancer ABC_E622 Neighboring gene STARR-seq mESC enhancer starr_46471 Neighboring gene programmed cell death 4 Neighboring gene STARR-seq mESC enhancer starr_46472 Neighboring gene STARR-seq mESC enhancer starr_46473 Neighboring gene BBSome interacting protein 1 Neighboring gene Shoc2, leucine rich repeat scaffold protein Neighboring gene STARR-seq mESC enhancer starr_46474 Neighboring gene STARR-seq mESC enhancer starr_46476 Neighboring gene STARR-seq mESC enhancer starr_46477 Neighboring gene predicted gene, 41865 Neighboring gene predicted gene, 41866

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Chemically induced (ENU) (2) 
  • Endonuclease-mediated (6) 
  • Targeted (6)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables adrenergic receptor activity PubMed 
enables alpha-2C adrenergic receptor binding  
enables alpha-2C adrenergic receptor binding  
enables alpha2-adrenergic receptor activity  
enables alpha2-adrenergic receptor activity PubMed 
enables alpha2-adrenergic receptor activity  
enables alpha2-adrenergic receptor activity PubMed 
enables epinephrine binding  
enables epinephrine binding  
enables epinephrine binding  
enables heterotrimeric G-protein binding  
enables heterotrimeric G-protein binding  
enables norepinephrine binding  
enables norepinephrine binding  
enables protein binding PubMed 
enables protein heterodimerization activity  
enables protein heterodimerization activity  
enables protein homodimerization activity  
enables protein homodimerization activity  
enables protein kinase binding  
enables protein kinase binding  
enables thioesterase binding  
enables thioesterase binding  
Items 1 - 25 of 54
Process Evidence Code Pubs
involved_in DNA replication  
involved_in DNA replication  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway PubMed 
involved_in G protein-coupled receptor signaling pathway  
involved_in activation of protein kinase B activity  
involved_in activation of protein kinase activity  
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway  
involved_in adenylate cyclase-inhibiting adrenergic receptor signaling pathway  
involved_in adrenergic receptor signaling pathway  
involved_in cellular response to hormone stimulus  
involved_in cellular response to hormone stimulus  
acts_upstream_of_or_within fear response PubMed 
involved_in female pregnancy  
involved_in female pregnancy  
involved_in glucose homeostasis  
involved_in glucose homeostasis  
involved_in negative regulation of calcium ion-dependent exocytosis  
involved_in negative regulation of calcium ion-dependent exocytosis  
involved_in negative regulation of insulin secretion PubMed 
involved_in negative regulation of insulin secretion PubMed 
involved_in negative regulation of insulin secretion  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in negative regulation of insulin secretion involved in cellular response to glucose stimulus  
involved_in negative regulation of lipid catabolic process  
involved_in negative regulation of lipid catabolic process  
involved_in negative regulation of uterine smooth muscle contraction  
involved_in negative regulation of uterine smooth muscle contraction  
involved_in phospholipase C-activating adrenergic receptor signaling pathway  
involved_in phospholipase C-activating adrenergic receptor signaling pathway  
involved_in platelet activation  
involved_in positive regulation of MAP kinase activity  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of MAPK cascade  
involved_in positive regulation of cell migration  
involved_in positive regulation of cell migration  
involved_in positive regulation of cytokine production  
involved_in positive regulation of cytokine production  
involved_in positive regulation of epidermal growth factor receptor signaling pathway  
involved_in positive regulation of epidermal growth factor receptor signaling pathway  
involved_in positive regulation of membrane protein ectodomain proteolysis  
involved_in positive regulation of membrane protein ectodomain proteolysis  
involved_in positive regulation of wound healing  
involved_in positive regulation of wound healing  
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in presynaptic modulation of chemical synaptic transmission PubMed 
involved_in receptor transactivation  
involved_in regulation of vasoconstriction  
involved_in response to alcohol  
involved_in response to morphine  
involved_in thermoception  
involved_in thermoception  
involved_in vasodilation  
involved_in vasodilation  
Items 1 - 25 of 54
Items 1 - 20 of 22
Component Evidence Code Pubs
located_in GABA-ergic synapse  
is_active_in GABA-ergic synapse  
located_in axon terminus  
located_in axon terminus  
located_in cytoplasm  
located_in cytoplasm  
is_active_in dopaminergic synapse PubMed 
is_active_in dopaminergic synapse PubMed 
is_active_in dopaminergic synapse PubMed 
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in neuronal cell body  
located_in neuronal cell body  
is_active_in plasma membrane  
located_in plasma membrane  
located_in postsynaptic density membrane  
is_active_in postsynaptic density membrane  
is_active_in postsynaptic membrane  
located_in presynaptic active zone membrane  
is_active_in presynaptic active zone membrane  
part_of receptor complex  
part_of receptor complex  
Items 1 - 20 of 22

General protein information

Preferred Names
alpha-2A adrenergic receptor
Names
alpha-2A adrenoceptor
alpha-2A adrenoreceptor
alpha-2AAR
alpha2A-adrenergic receptor
subtype alpha2-C10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007417.5NP_031443.4  alpha-2A adrenergic receptor

    See identical proteins and their annotated locations for NP_031443.4

    Status: VALIDATED

    Source sequence(s)
    AC113491
    Consensus CDS
    CCDS29905.1
    UniProtKB/Swiss-Prot
    Q01338, Q3URE6
    UniProtKB/TrEMBL
    Q1HL33
    Related
    ENSMUSP00000036203.6, ENSMUST00000036700.7
    Conserved Domains (1) summary
    cd15322
    Location:49452
    7tmA_alpha2A_AR; alpha-2 adrenergic receptors subtype A, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    54033690..54037413
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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