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Zfp37 zinc finger protein 37 [ Rattus norvegicus (Norway rat) ]

Gene ID: 115768, updated on 3-Apr-2024

Summary

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Symbol
Zfp37provided by RGD
Full Name
zinc finger protein 37provided by RGD
Primary source
RGD:620723
See related
Ensembl:ENSRNOG00000069865 AllianceGenome:RGD:620723
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in cell differentiation and cell population proliferation. Predicted to be located in nucleus. Orthologous to human ZFP37 (ZFP37 zinc finger protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Testes (RPKM 25.6), Kidney (RPKM 19.6) and 9 other tissues See more
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Genomic context

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See Zfp37 in Genome Data Viewer
Location:
5q24
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (80600463..80656064, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (75598732..75638896, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (77829492..77945361, complement)

Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene major urinary protein-like Neighboring gene major urinary protein 4, pseudogene 5 Neighboring gene transfer RNA proline (anticodon GGG) 4 Neighboring gene RIKEN cDNA 3110040M04 gene like 2 Neighboring gene uncharacterized LOC108350981

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of a novel peroxisome proliferator responsive cDNA isolated from rat hepatocytes as the zinc-finger protein ZFP-37. Vanden Heuvel JP, et al. Toxicol Appl Pharmacol, 1998 Sep. PMID 9772206
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 37
Names
zfp-37

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_058209.2 → NP_478116.2  zinc finger protein 37

    Status: VALIDATED

    Source sequence(s)
    BC166844, CB727538
    UniProtKB/TrEMBL
    A0A8I6AAE9
    Related
    ENSRNOP00000089492.1, ENSRNOT00000100489.1
    Conserved Domains (6) summary
    cd07765
    Location:28 → 68
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:41 → 89
    KRAB; krueppel associated box
    COG5048
    Location:124 → 518
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:429 → 449
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:371 → 393
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:385 → 410
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086023.1 Reference GRCr8

    Range
    80600463..80656064 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039109135.2 → XP_038965063.1  zinc finger protein 37 isoform X2

    UniProtKB/TrEMBL
    A6J7T5
    Conserved Domains (4) summary
    smart00349
    Location:38 → 88
    KRAB; krueppel associated box
    COG5048
    Location:272 → 597
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:428 → 448
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:594 → 616
    zf-C2H2; Zinc finger, C2H2 type

  2. XM_063287064.1 → XP_063143134.1  zinc finger protein 37 isoform X1

    UniProtKB/TrEMBL
    A0A8I6AAE9

  3. XM_039109136.2 → XP_038965064.1  zinc finger protein 37 isoform X3

    UniProtKB/TrEMBL
    F1LYQ2
    Related
    ENSRNOP00000053737.5
    Conserved Domains (4) summary
    COG5048
    Location:230 → 555
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:386 → 406
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:552 → 574
    zf-C2H2; Zinc finger, C2H2 type
    cl02581
    Location:41 → 69
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  4. XM_039109137.2 → XP_038965065.1  zinc finger protein 37 isoform X4

    Conserved Domains (4) summary
    COG5048
    Location:229 → 554
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:385 → 405
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:551 → 573
    zf-C2H2; Zinc finger, C2H2 type
    cl02581
    Location:38 → 68
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box

  5. XM_039109140.2 → XP_038965068.1  zinc finger protein 37 isoform X5

    Related
    ENSRNOP00000077492.1
    Conserved Domains (2) summary
    COG5048
    Location:206 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]

  6. XM_039109138.2 → XP_038965066.1  zinc finger protein 37 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:206 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]

  7. XM_039109139.2 → XP_038965067.1  zinc finger protein 37 isoform X5

    Conserved Domains (2) summary
    COG5048
    Location:206 → 531
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:362 → 382
    ZF_C2H2; C2H2 Zn finger [structural motif]
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88553.1 GenPept UniProtKB/Swiss-Prot:O88553

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