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Ahcyl adenosylhomocysteinase like [ Mus musculus (house mouse) ]

Gene ID: 11615, updated on 4-Jan-2025

Summary

Official Symbol
Ahcylprovided by MGI
Official Full Name
adenosylhomocysteinase likeprovided by MGI
Primary source
MGI:MGI:3643647
See related
Ensembl:ENSMUSG00000048087 AllianceGenome:MGI:3643647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Gm4737; EG11615; AL024110
Summary
Predicted to enable NAD binding activity; adenosylhomocysteinase activity; and identical protein binding activity. Predicted to be involved in several processes, including S-adenosylhomocysteine catabolic process; chronic inflammatory response to antigenic stimulus; and circadian sleep/wake cycle. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm and hypermethioninemia with deficiency of S-adenosylhomocysteine hydrolase. Orthologous to human AHCY (adenosylhomocysteinase). [provided by Alliance of Genome Resources, Jan 2025]
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Genomic context

See Ahcyl in Genome Data Viewer
Location:
16 B5; 16 30.45 cM
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45973348..45975440, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (46152985..46155077, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31198 Neighboring gene CD96 antigen Neighboring gene STARR-seq mESC enhancer starr_40924 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46104635-46104888 Neighboring gene zinc finger BED-type containing 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46120234-46120417 Neighboring gene predicted gene, 26297 Neighboring gene nectin cell adhesion molecule 3

Genomic regions, transcripts, and products

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables NAD binding  
enables adenosylhomocysteinase activity  
enables adenyl nucleotide binding  
enables identical protein binding  
Component Evidence Code Pubs
located_in cytosol  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304528.1NP_001291457.1  Adenosylhomocysteinase

    See identical proteins and their annotated locations for NP_001291457.1

    Status: VALIDATED

    Source sequence(s)
    AC139039
    Consensus CDS
    CCDS84240.1
    UniProtKB/Swiss-Prot
    P50247, Q91WF1
    UniProtKB/TrEMBL
    Q3TF14, Q3U4D1, Q5M9P0
    Related
    ENSMUSP00000127198.2, ENSMUST00000059524.7
    Conserved Domains (1) summary
    smart00996
    Location:8431
    AdoHcyase; S-adenosyl-L-homocysteine hydrolase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45973348..45975440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

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