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Dnajc2 DnaJ heat shock protein family (Hsp40) member C2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116456, updated on 2-May-2024

Summary

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Official Symbol
Dnajc2provided by RGD
Official Full Name
DnaJ heat shock protein family (Hsp40) member C2provided by RGD
Primary source
RGD:620524
See related
Ensembl:ENSRNOG00000012392 AllianceGenome:RGD:620524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Zrf2; MIDA1
Summary
Predicted to enable several functions, including Hsp70 protein binding activity; ribosome binding activity; and ubiquitin modification-dependent histone binding activity. Involved in negative regulation of cell growth. Predicted to be located in cytoplasm; nuclear membrane; and nucleolus. Predicted to be active in cytosol. Orthologous to human DNAJC2 (DnaJ heat shock protein family (Hsp40) member C2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Thymus (RPKM 181.9), Testes (RPKM 170.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Dnajc2 in Genome Data Viewer
Location:
4q11
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (14162490..14189662)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (13270239..13297438)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (9881505..9908693)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene solute carrier family 26 member 5 Neighboring gene proteasome 26S subunit, ATPase 2 Neighboring gene small nucleolar RNA SNORA48 Neighboring gene peptidase, mitochondrial processing subunit beta Neighboring gene ADP-ribosylation factor 1, pseudogene 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Immunization with an antigen identified by cytokine tumor vaccine-assisted SEREX (CAS) suppressed growth of the rat 9L glioma in vivo. Okada H, et al. Cancer Res, 2001 Mar 15. PMID 11289140
  2. MIDA1, a protein associated with Id, regulates cell growth. Shoji W, et al. J Biol Chem, 1995 Oct 20. PMID 7559602
  3. The chaperones MPP11 and Hsp70L1 form the mammalian ribosome-associated complex. Otto H, et al. Proc Natl Acad Sci U S A, 2005 Jul 19. PMID 16002468, Free PMC Article
  4. Transcriptional activation of polycomb-repressed genes by ZRF1. Richly H, et al. Nature, 2010 Dec 23. PMID 21179169
  5. Identification of novel M phase phosphoproteins by expression cloning. Matsumoto-Taniura N, et al. Mol Biol Cell, 1996 Sep. PMID 8885239, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Clone Names

  • MGC105894

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables Hsp70 protein binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Hsp70 protein binding IEA
Inferred from Electronic Annotation
more info
  
enables Hsp70 protein binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding IEA
Inferred from Electronic Annotation
more info
  
enables chromatin binding ISO
Inferred from Sequence Orthology
more info
  
enables chromatin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone binding IEA
Inferred from Electronic Annotation
more info
  
enables histone binding ISO
Inferred from Sequence Orthology
more info
  
enables histone binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ribosome binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-modified histone reader activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-modified histone reader activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-modified histone reader activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in 'de novo' cotranslational protein folding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' cotranslational protein folding IEA
Inferred from Electronic Annotation
more info
  
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within DNA replication ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin organization IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of DNA biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within negative regulation of DNA biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of cell growth IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of translational fidelity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dnaJ homolog subfamily C member 2
Names
(rat homolog) mouse id-associated protein 1
DnaJ (Hsp40) homolog, subfamily C, member 2
gliosarcoma-related antigen MIDA1
zuotin related factor 2
zuotin-related factor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053776.3 → NP_446228.2  dnaJ homolog subfamily C member 2

    See identical proteins and their annotated locations for NP_446228.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/Swiss-Prot
    Q5HZY5, Q7TQ18, Q7TQ20, Q9WVG4
    UniProtKB/TrEMBL
    A0A0G2JSM0, A6K5A5
    Related
    ENSRNOP00000016909.5, ENSRNOT00000016909.8
    Conserved Domains (5) summary
    smart00717
    Location:553 → 602
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:553 → 600
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:88 → 158
    DnaJ; DnaJ domain
    pfam16717
    Location:349 → 420
    RAC_head; Ribosome-associated complex head domain
    cl20817
    Location:288 → 353
    GBP_C; Guanylate-binding protein, C-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    14162490..14189662
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008762628.4 → XP_008760850.1  dnaJ homolog subfamily C member 2 isoform X1

    See identical proteins and their annotated locations for XP_008760850.1

    UniProtKB/Swiss-Prot
    Q5HZY5, Q7TQ18, Q7TQ20, Q9WVG4
    UniProtKB/TrEMBL
    A0A0G2JSM0, A6K5A5
    Related
    ENSRNOP00000082213.1
    Conserved Domains (5) summary
    smart00717
    Location:553 → 602
    SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
    cd00167
    Location:553 → 600
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    pfam00226
    Location:88 → 158
    DnaJ; DnaJ domain
    pfam16717
    Location:349 → 420
    RAC_head; Ribosome-associated complex head domain
    cl20817
    Location:288 → 353
    GBP_C; Guanylate-binding protein, C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7TQ20.1 GenPept UniProtKB/Swiss-Prot:Q7TQ20

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