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Sec14l2 SEC14-like lipid binding 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116486, updated on 5-Mar-2024

Summary

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Official Symbol
Sec14l2provided by RGD
Official Full Name
SEC14-like lipid binding 2provided by RGD
Primary source
RGD:621779
See related
Ensembl:ENSRNOG00000004672 AllianceGenome:RGD:621779
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Spf
Summary
Enables enzyme activator activity and transferase activity, transferring alkyl or aryl (other than methyl) groups. Involved in positive regulation of cholesterol biosynthetic process. Located in cytosol. Orthologous to human SEC14L2 (SEC14 like lipid binding 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 499.5), Brain (RPKM 140.6) and 4 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Sec14l2 in Genome Data Viewer
Location:
14q21
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (83197384..83222059, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (78973805..78998480, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (84335594..84360354, complement)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene SEC14-like lipid binding 3 Neighboring gene uncharacterized LOC102549281 Neighboring gene mitochondrial fission process 1 Neighboring gene ring finger protein 215 Neighboring gene uncharacterized LOC134481866 Neighboring gene coiled-coil domain containing 157

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells. Mokashi V, et al. Arch Biochem Biophys, 2005 Mar 1. PMID 15680919
  2. Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro. Mokashi V, et al. Arch Biochem Biophys, 2005 Jan 15. PMID 15581604
  3. Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues. Liu J, et al. Mol Omics, 2021 Jun 14. PMID 34008672
  4. Tocopherol-associated protein is a ligand-dependent transcriptional activator. Yamauchi J, et al. Biochem Biophys Res Commun, 2001 Jul 13. PMID 11444841
  5. Supernatant protein factor, which stimulates the conversion of squalene to lanosterol, is a cytosolic squalene transfer protein and enhances cholesterol biosynthesis. Shibata N, et al. Proc Natl Acad Sci U S A, 2001 Feb 27. PMID 11226224, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
    Title: Proteome-wide analysis of protein alterations in response to aristolochic acids in rat kidney and liver tissues.
  2. Sec14l2 stimulates HMG-CoA reductase in hepatoma cell cultures.
    Title: Supernatant protein factor stimulates HMG-CoA reductase in cell culture and in vitro.
  3. overexpression of SEC14L1 modestly decreases high affinity choline transport activity
    Title: SEC14-like protein 1 interacts with cholinergic transporters.
  4. The activation of SPF by PKA suggests that cholesterol synthesis can be rapidly modulated in response to external stimuli by changes in cAMP levels, and that this regulation is dependent on an as yet undefined interaction with Golgi.
    Title: Supernatant protein factor requires phosphorylation and interaction with Golgi to stimulate cholesterol synthesis in hepatoma cells.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables enzyme activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity, transferring alkyl or aryl (other than methyl) groups IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of cholesterol biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
SEC14-like protein 2
Names
TAP
alpha-tocopherol-associated protein
squalene transfer protein
supernatant protein factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053801.2 → NP_446253.2  SEC14-like protein 2

    See identical proteins and their annotated locations for NP_446253.2

    Status: PROVISIONAL

    Source sequence(s)
    BC089785
    UniProtKB/TrEMBL
    F7F3C3, Q5EBD0
    Related
    ENSRNOP00000006542.4, ENSRNOT00000006542.5
    Conserved Domains (2) summary
    smart00516
    Location:76 → 244
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:13 → 59
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    83197384..83222059 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006251154.5 → XP_006251216.1  SEC14-like protein 2 isoform X1

    UniProtKB/TrEMBL
    F7F3C3
    Conserved Domains (1) summary
    smart00516
    Location:22 → 190
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)

  2. XM_039091558.2 → XP_038947486.1  SEC14-like protein 2 isoform X2

    UniProtKB/TrEMBL
    A0A8I6ADK3
    Conserved Domains (2) summary
    smart00516
    Location:76 → 244
    SEC14; Domain in homologues of a S. cerevisiae phosphatidylinositol transfer protein (Sec14p)
    smart01100
    Location:13 → 59
    CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MS0.1 GenPept UniProtKB/Swiss-Prot:Q99MS0

Gene LinkOut

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