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Mprip myosin phosphatase Rho interacting protein [ Rattus norvegicus (Norway rat) ]

Gene ID: 116504, updated on 13-Apr-2024

Summary

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Official Symbol
Mpripprovided by RGD
Official Full Name
myosin phosphatase Rho interacting proteinprovided by RGD
Primary source
RGD:619947
See related
Ensembl:ENSRNOG00000003226 AllianceGenome:RGD:619947
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Mrip; M-rip; Rhoip3; p116Rip
Summary
Predicted to enable actin filament binding activity. Involved in maintenance of protein location in cell; negative regulation of myosin-light-chain-phosphatase activity; and positive regulation of protein phosphorylation. Located in stress fiber. Orthologous to human MPRIP (myosin phosphatase Rho interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 366.3), Brain (RPKM 254.0) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Mprip in Genome Data Viewer
Location:
10q22
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (44953472..45073388)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (44453949..44573843)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (46018397..46133580)

Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 2 subfamily W member 25, pseudogene 1 Neighboring gene ribosomal protein L15, pseudogene 6 Neighboring gene uncharacterized LOC120095110 Neighboring gene phospholipase D family, member 6 Neighboring gene folliculin

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
    Title: Role of the RIP3-PGAM5-Drp1 pathway in aluminum-induced PC12 cells necroptosis.
  2. RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
    Title: RIP3 Inhibition ameliorates chronic constriction injury-induced neuropathic pain by suppressing JNK signaling.
  3. The results indicated that RIP3 is expressed differentially in retinal neurons in adult rats, including subsets of ganglion cells, amacrine and horizontal cells. RIP3 protein levels are elevated rapidly following aHIOP
    Title: Differential neuronal expression of receptor interacting protein 3 in rat retina: involvement in ischemic stress response.
  4. decreased insulin-stimulated MRIP/MYPT1 association may contribute to the impaired insulin-mediated vasodilation observed in the diabetic vasculature
    Title: Impaired insulin-stimulated myosin phosphatase Rho-interacting protein signaling in diabetic Goto-Kakizaki vascular smooth muscle cells.
  5. myosin phosphatase-rho interacting protein is a scaffold linking RhoA to regulate myosin phosphatase at the stress fiber.
    Title: Targeting by myosin phosphatase-RhoA interacting protein mediates RhoA/ROCK regulation of myosin phosphatase.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC114284

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in maintenance of protein location in cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in stress fiber IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
myosin phosphatase Rho-interacting protein
Names
RIP3
Rho interacting protein 3
rho-interacting protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001034022.2 → NP_001029194.1  myosin phosphatase Rho-interacting protein isoform 3

    See identical proteins and their annotated locations for NP_001029194.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q4KM03, Q9ERE6
    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:358 → 459
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:631 → 941
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. NM_001371051.2 → NP_001357980.1  myosin phosphatase Rho-interacting protein isoform 1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/TrEMBL
    A0A8I5ZXY0, A0A8I6A006
    Related
    ENSRNOP00000084454.1, ENSRNOT00000100281.1
    Conserved Domains (4) summary
    COG1196
    Location:932 → 1219
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:512 → 613
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:771 → 1065
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  3. NM_001414223.1 → NP_001401152.1  myosin phosphatase Rho-interacting protein isoform 4

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010

  4. NM_053814.3 → NP_446266.2  myosin phosphatase Rho-interacting protein isoform 2

    See identical proteins and their annotated locations for NP_446266.2

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000010
    UniProtKB/Swiss-Prot
    Q4KM03, Q9ERE6
    UniProtKB/TrEMBL
    A6HF15
    Conserved Domains (3) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:394 → 495
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:667 → 977
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086028.1 Reference GRCr8

    Range
    44953472..45073388
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006246424.5 → XP_006246486.1  myosin phosphatase Rho-interacting protein isoform X2

    See identical proteins and their annotated locations for XP_006246486.1

    UniProtKB/TrEMBL
    A0A8I5ZXY0, A0A8I6A006
    Conserved Domains (4) summary
    COG1196
    Location:932 → 1219
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:512 → 613
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    TIGR02168
    Location:771 → 1065
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_063268288.1 → XP_063124358.1  myosin phosphatase Rho-interacting protein isoform X1

  3. XM_063268291.1 → XP_063124361.1  myosin phosphatase Rho-interacting protein isoform X6

  4. XM_063268292.1 → XP_063124362.1  myosin phosphatase Rho-interacting protein isoform X8

  5. XM_006246431.5 → XP_006246493.1  myosin phosphatase Rho-interacting protein isoform X11

    UniProtKB/Swiss-Prot
    Q4KM03, Q9ERE6
    UniProtKB/TrEMBL
    G3V9F3
    Related
    ENSRNOP00000045501.4
    Conserved Domains (6) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:512 → 613
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:512 → 600
    PH; PH domain
    pfam15619
    Location:801 → 1002
    Lebercilin; Ciliary protein causing Leber congenital amaurosis disease
    cl02488
    Location:860 → 1098
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl03951
    Location:761 → 879
    CDC37_N; Cdc37 N terminal kinase binding

  6. XM_063268295.1 → XP_063124365.1  myosin phosphatase Rho-interacting protein isoform X12

  7. XM_006246425.5 → XP_006246487.1  myosin phosphatase Rho-interacting protein isoform X4

    UniProtKB/TrEMBL
    A0A0G2JUR5, A0A8I6A006
    Related
    ENSRNOP00000069198.2
    Conserved Domains (5) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:394 → 495
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:394 → 482
    PH; PH domain
    pfam01442
    Location:1948 → 2122
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam17045
    Location:820 → 1044
    CEP63; Centrosomal protein of 63 kDa

  8. XM_006246432.5 → XP_006246494.1  myosin phosphatase Rho-interacting protein isoform X14

    UniProtKB/Swiss-Prot
    Q4KM03, Q9ERE6
    Conserved Domains (5) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:394 → 495
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:394 → 482
    PH; PH domain
    cl02488
    Location:742 → 980
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    cl03951
    Location:643 → 761
    CDC37_N; Cdc37 N terminal kinase binding

  9. XM_063268298.1 → XP_063124368.1  myosin phosphatase Rho-interacting protein isoform X16

  10. XM_006246427.5 → XP_006246489.1  myosin phosphatase Rho-interacting protein isoform X7

    UniProtKB/TrEMBL
    A0A140TA95, A0A8I6A006
    Related
    ENSRNOP00000004357.7
    Conserved Domains (5) summary
    cd01236
    Location:16 → 151
    PH_RIP; Rho-Interacting Protein Pleckstrin homology (PH) domain
    cd13275
    Location:358 → 459
    PH_M-RIP; Myosin phosphatase-RhoA Interacting Protein Pleckstrin homology (PH) domain
    pfam00169
    Location:358 → 446
    PH; PH domain
    pfam01442
    Location:1912 → 2086
    Apolipoprotein; Apolipoprotein A1/A4/E domain
    pfam17045
    Location:784 → 1008
    CEP63; Centrosomal protein of 63 kDa

  11. XM_017596957.3 → XP_017452446.1  myosin phosphatase Rho-interacting protein isoform X18

    UniProtKB/Swiss-Prot
    Q4KM03, Q9ERE6

  12. XM_063268301.1 → XP_063124371.1  myosin phosphatase Rho-interacting protein isoform X20

  13. XM_063268297.1 → XP_063124367.1  myosin phosphatase Rho-interacting protein isoform X15

    UniProtKB/TrEMBL
    A6HF15

  14. XM_063268300.1 → XP_063124370.1  myosin phosphatase Rho-interacting protein isoform X19

  15. XM_063268294.1 → XP_063124364.1  myosin phosphatase Rho-interacting protein isoform X10

  16. XM_063268289.1 → XP_063124359.1  myosin phosphatase Rho-interacting protein isoform X3

  17. XM_063268296.1 → XP_063124366.1  myosin phosphatase Rho-interacting protein isoform X13

  18. XM_063268290.1 → XP_063124360.1  myosin phosphatase Rho-interacting protein isoform X5

  19. XM_063268299.1 → XP_063124369.1  myosin phosphatase Rho-interacting protein isoform X17

  20. XM_063268293.1 → XP_063124363.1  myosin phosphatase Rho-interacting protein isoform X9

  21. XM_039085047.2 → XP_038940975.2  myosin phosphatase Rho-interacting protein isoform X9

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9ERE6.1 GenPept UniProtKB/Swiss-Prot:Q9ERE6

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