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Timp1 TIMP metallopeptidase inhibitor 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116510, updated on 4-Jan-2025

Summary

Official Symbol
Timp1provided by RGD
Official Full Name
TIMP metallopeptidase inhibitor 1provided by RGD
Primary source
RGD:621675
See related
EnsemblRapid:ENSRNOG00000010208 AllianceGenome:RGD:621675
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Timp; TIMP-1
Summary
Enables protease binding activity. Involved in several processes, including cartilage development; cellular response to peptide; and response to peptide hormone. Located in basement membrane. Used to study degenerative disc disease. Biomarker of several diseases, including gastric ulcer; heart disease (multiple); lung disease (multiple); metabolic dysfunction-associated steatohepatitis; and vascular disease (multiple). Orthologous to human TIMP1 (TIMP metallopeptidase inhibitor 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Lung (RPKM 146.9), Uterus (RPKM 130.4) and 9 other tissues See more
Orthologs
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Genomic context

See Timp1 in Genome Data Viewer
Location:
Xq11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) X NC_086039.1 (3766509..3772578, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) X NC_051356.1 (1212969..1217714, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) X NC_005120.4 (1364771..1369451, complement)

Chromosome X - NC_086039.1Genomic Context describing neighboring genes Neighboring gene complement factor properdin Neighboring gene synapsin I Neighboring gene 60S ribosomal protein L12-like Neighboring gene A-Raf proto-oncogene, serine/threonine kinase Neighboring gene uncharacterized LOC134484040 Neighboring gene small ribosomal subunit protein eS24-like Neighboring gene ribosomal protein L22 like 1, pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables cytokine activity  
enables cytokine activity  
enables growth factor activity  
enables metalloendopeptidase inhibitor activity  
enables metalloendopeptidase inhibitor activity  
enables metalloendopeptidase inhibitor activity  
enables metalloendopeptidase inhibitor activity PubMed 
enables peptidase inhibitor activity  
enables protease binding PubMed 
enables protein binding PubMed 
enables zinc ion binding  
Process Evidence Code Pubs
involved_in cartilage development PubMed 
involved_in cellular response to UV-A  
involved_in cellular response to UV-A  
involved_in cellular response to peptide PubMed 
acts_upstream_of_or_within connective tissue replacement involved in inflammatory response wound healing  
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of catalytic activity  
involved_in negative regulation of catalytic activity  
involved_in negative regulation of endopeptidase activity  
involved_in negative regulation of endopeptidase activity  
involved_in negative regulation of membrane protein ectodomain proteolysis  
involved_in negative regulation of membrane protein ectodomain proteolysis  
involved_in negative regulation of metallopeptidase activity  
involved_in negative regulation of trophoblast cell migration  
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in regulation of integrin-mediated signaling pathway  
involved_in regulation of integrin-mediated signaling pathway  
involved_in response to cytokine  
involved_in response to cytokine PubMed 
involved_in response to hormone  
involved_in response to peptide hormone PubMed 
involved_in signal transduction  
involved_in steroid biosynthetic process  
Component Evidence Code Pubs
located_in basement membrane PubMed 
located_in basement membrane  
is_active_in extracellular matrix  
located_in extracellular matrix  
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  

General protein information

Preferred Names
metalloproteinase inhibitor 1
Names
tissue inhibitor of metallopeptidase 1
tissue inhibitor of metalloproteinase 1
tissue inhibitor of metalloproteinases 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053819.1NP_446271.1  metalloproteinase inhibitor 1 precursor

    See identical proteins and their annotated locations for NP_446271.1

    Status: PROVISIONAL

    Source sequence(s)
    L31883
    UniProtKB/Swiss-Prot
    P30120, P70533, Q53YM7
    UniProtKB/TrEMBL
    A6JZR1
    Related
    ENSRNOP00000013745.4, ENSRNOT00000013745.9
    Conserved Domains (1) summary
    smart00206
    Location:24199
    NTR; Tissue inhibitor of metalloproteinase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086039.1 Reference GRCr8

    Range
    3766509..3772578 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006256608.4XP_006256670.1  metalloproteinase inhibitor 1 isoform X1

    See identical proteins and their annotated locations for XP_006256670.1

    UniProtKB/Swiss-Prot
    P30120, P70533, Q53YM7
    UniProtKB/TrEMBL
    A6JZR1
    Conserved Domains (1) summary
    smart00206
    Location:24199
    NTR; Tissue inhibitor of metalloproteinase family
  2. XM_039099406.2XP_038955334.1  metalloproteinase inhibitor 1 isoform X1

    UniProtKB/Swiss-Prot
    P30120, P70533, Q53YM7
    UniProtKB/TrEMBL
    A6JZR1
    Conserved Domains (1) summary
    smart00206
    Location:24199
    NTR; Tissue inhibitor of metalloproteinase family
  3. XM_039099407.2XP_038955335.1  metalloproteinase inhibitor 1 isoform X1

    UniProtKB/Swiss-Prot
    P30120, P70533, Q53YM7
    UniProtKB/TrEMBL
    A6JZR1
    Conserved Domains (1) summary
    smart00206
    Location:24199
    NTR; Tissue inhibitor of metalloproteinase family
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