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Cplx2 complexin 2 [ Rattus norvegicus (Norway rat) ]

Gene ID: 116657, updated on 3-Apr-2024

Summary

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Official Symbol
Cplx2provided by RGD
Official Full Name
complexin 2provided by RGD
Primary source
RGD:70945
See related
Ensembl:ENSRNOG00000000105 AllianceGenome:RGD:70945
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables calcium-dependent protein binding activity and syntaxin-1 binding activity. Involved in synaptic vesicle exocytosis. Located in dendrite; neuronal cell body; and synapse. Part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex. Is active in postsynapse and presynapse. Orthologous to human CPLX2 (complexin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 1041.7) and Adrenal (RPKM 63.0) See more
Orthologs
human mouse all
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Genomic context

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Location:
17p14
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (10224673..10297974, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (10219577..10292835, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (10756871..10828811, complement)

Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene THO complex subunit 3 Neighboring gene uncharacterized LOC120097924 Neighboring gene long non-coding RNA 012 Neighboring gene uncharacterized LOC134482680 Neighboring gene histamine receptor H 2 Neighboring gene ribosomal protein lateral stalk subunit P0, pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification of complexin II in astrocytes: a possible regulator of glutamate release in these cells. Hazell AS, et al. Biochem Biophys Res Commun, 2011 Jan 7. PMID 21110949
  2. Overexpression of complexin in PC12 cells inhibits exocytosis by preventing SNARE complex recycling. Liu J, et al. Biochemistry (Mosc), 2007 Apr. PMID 17511609
  3. Identification of okadaic acid-induced phosphorylation events by a mass spectrometry approach. Hill JJ, et al. Biochem Biophys Res Commun, 2006 Apr 14. PMID 16499873
  4. Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion process. Tadokoro S, et al. J Cell Sci, 2005 May 15. PMID 15870114
  5. Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation. Pavarotti MA, et al. Biochem J, 2021 Jan 29. PMID 33393983

See all (24) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats.
    Title: Involvement of miR-135a-5p Downregulation in Acute and Chronic Stress Response in the Prefrontal Cortex of Rats.
  2. Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation.
    Title: Complexin-2 redistributes to the membrane of muscle cells in response to insulin and contributes to GLUT4 translocation.
  3. These findings point to Cpx II being a likely key modulator of synaptic activity at the level of astrocytes.
    Title: Identification of complexin II in astrocytes: a possible regulator of glutamate release in these cells.
  4. Data showv that complexin 2 interacts with vesicle-associated membrane protein (VAMP) 2, syntaxins 3 and 4.
    Title: Complexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini.
  5. results suggest that complexin II regulates degranulation by interacting with the SNARE complex containing syntaxin-3.
    Title: Complexin II regulates degranulation in RBL-2H3 cells by interacting with SNARE complex containing syntaxin-3.
  6. Transient increases in the levels of complexin I and complexin II proteins were detected in the injured cerebral cortex 6 h following TBI.
    Title: Early, transient increase in complexin I and complexin II in the cerebral cortex following traumatic brain injury is attenuated by N-acetylcysteine.
  7. Complexin II regulates exocytosis positively by translocating to the plasma membrane and enhancing the Ca2+ sensitivity of fusion machinery.
    Title: Complexin II facilitates exocytotic release in mast cells by enhancing Ca2+ sensitivity of the fusion process.
  8. complexins modulate neuroexocytosis after assembly of membrane-bridging SNARE complexes
    Title: Rapid and selective binding to the synaptic SNARE complex suggests a modulatory role of complexins in neuroexocytosis.
  9. high levels of complexin seem to prevent SNARE complex recycling, presumably by displacing NSF and alpha-SNAP from SNARE complex.
    Title: Overexpression of complexin in PC12 cells inhibits exocytosis by preventing SNARE complex recycling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables SNARE binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium-dependent protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin-1 binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in mast cell degranulation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of neurotransmitter secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of synaptic vesicle fusion to presynaptic active zone membrane ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in synaptic vesicle exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in vesicle docking involved in exocytosis TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of SNARE complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of SNARE complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in calyx of Held ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
part_of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in terminal bouton HDA PubMed 
is_active_in terminal bouton IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
complexin-2
Names
CPX II
complexin II
synaphin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053878.3 → NP_446330.1  complexin-2

    See identical proteins and their annotated locations for NP_446330.1

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000017
    UniProtKB/Swiss-Prot
    P84087
    UniProtKB/TrEMBL
    A6KB03
    Conserved Domains (1) summary
    pfam05835
    Location:1 → 133
    Synaphin; Synaphin protein

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086035.1 Reference GRCr8

    Range
    10224673..10297974 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039095303.2 → XP_038951231.1  complexin-2 isoform X1

    UniProtKB/Swiss-Prot
    P84087
    UniProtKB/TrEMBL
    A6KB03
    Related
    ENSRNOP00000072664.1
    Conserved Domains (1) summary
    pfam05835
    Location:1 → 133
    Synaphin; Synaphin protein

  2. XM_017600440.3 → XP_017455929.1  complexin-2 isoform X1

    UniProtKB/Swiss-Prot
    P84087
    UniProtKB/TrEMBL
    A6KB03
    Conserved Domains (1) summary
    pfam05835
    Location:1 → 133
    Synaphin; Synaphin protein

  3. XM_017600441.3 → XP_017455930.1  complexin-2 isoform X1

    UniProtKB/Swiss-Prot
    P84087
    UniProtKB/TrEMBL
    A6KB03
    Conserved Domains (1) summary
    pfam05835
    Location:1 → 133
    Synaphin; Synaphin protein

  4. XM_063276028.1 → XP_063132098.1  complexin-2 isoform X1

    UniProtKB/Swiss-Prot
    P84087
    UniProtKB/TrEMBL
    A6KB03
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P84087.1 GenPept UniProtKB/Swiss-Prot:P84087

Gene LinkOut

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