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Ptprn protein tyrosine phosphatase, receptor type, N [ Rattus norvegicus (Norway rat) ]

Gene ID: 116660, updated on 4-Jan-2025

Summary

Official Symbol
Ptprnprovided by RGD
Official Full Name
protein tyrosine phosphatase, receptor type, Nprovided by RGD
Primary source
RGD:620777
See related
EnsemblRapid:ENSRNOG00000019587 AllianceGenome:RGD:620777
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Ia-2; BEM-3; PTPLP; ICA105; ICA512; R-PTP-N
Summary
Enables GTPase binding activity. Involved in several processes, including positive regulation of type B pancreatic cell proliferation; response to cAMP; and response to estrogen. Located in several cellular components, including axon terminus; cytoplasmic vesicle; and neuronal cell body. Is active in neuronal dense core vesicle membrane. Used to study type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human PTPRN (protein tyrosine phosphatase receptor type N). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 408.1), Kidney (RPKM 140.4) and 3 other tissues See more
Orthologs
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Genomic context

See Ptprn in Genome Data Viewer
Location:
9q33
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (84189676..84205364, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (76741010..76756704, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (82446626..82462314, complement)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102554903 Neighboring gene tubulin, alpha 4A Neighboring gene DnaJ heat shock protein family (Hsp40) member B2 Neighboring gene uncharacterized LOC120094712 Neighboring gene regulated endocrine-specific protein 18 Neighboring gene aspartyl aminopeptidase

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GTPase binding PubMed 
enables protein tyrosine phosphatase activity  
NOT enables protein tyrosine phosphatase activity  
NOT enables protein tyrosine phosphatase activity  
enables spectrin binding  
enables spectrin binding  
enables ubiquitin-like protein ligase binding  
enables ubiquitin-like protein ligase binding  
Process Evidence Code Pubs
involved_in dense core granule maturation  
involved_in dense core granule maturation  
involved_in insulin secretion  
involved_in insulin secretion  
involved_in insulin secretion involved in cellular response to glucose stimulus  
involved_in insulin secretion involved in cellular response to glucose stimulus  
involved_in insulin secretion involved in cellular response to glucose stimulus  
involved_in luteinization  
involved_in luteinization  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of type B pancreatic cell proliferation  
involved_in positive regulation of type B pancreatic cell proliferation PubMed 
involved_in positive regulation of type B pancreatic cell proliferation  
involved_in regulation of secretion  
involved_in response to cAMP PubMed 
involved_in response to estrogen PubMed 
involved_in response to glucose PubMed 
involved_in response to insulin PubMed 
involved_in response to reactive oxygen species  
involved_in response to reactive oxygen species  
involved_in response to reactive oxygen species  
Component Evidence Code Pubs
located_in Golgi apparatus PubMed 
located_in axon terminus PubMed 
located_in endosome PubMed 
located_in neuronal cell body PubMed 
is_active_in neuronal dense core vesicle membrane PubMed 
located_in nucleus  
located_in nucleus  
located_in perikaryon  
located_in plasma membrane PubMed 
is_active_in secretory granule  
located_in secretory granule PubMed 
located_in secretory granule  
is_active_in synapse  
located_in synapse PubMed 
located_in synapse  
NOT located_in synaptic vesicle PubMed 
located_in transport vesicle membrane  

General protein information

Preferred Names
receptor-type tyrosine-protein phosphatase-like N
Names
105 kDa islet cell antigen
brain-enriched membrane-associated protein tyrosine phosphatase
NP_446333.2
XP_006245196.1
XP_017451718.1
XP_017451719.1
XP_063122605.1
XP_063122606.1
XP_063122607.1
XP_063122608.1
XP_063122609.1
XP_063122610.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053881.2NP_446333.2  receptor-type tyrosine-protein phosphatase-like N precursor

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    Q62883, Q63259, Q63795, Q64643
    UniProtKB/TrEMBL
    A0A8I6A9W6, A6JW12
    Related
    ENSRNOP00000026654.6, ENSRNOT00000026654.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    84189676..84205364 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017596230.3XP_017451719.1  receptor-type tyrosine-protein phosphatase-like N isoform X3

    UniProtKB/TrEMBL
    A0A8I5ZW92
  2. XM_017596229.2XP_017451718.1  receptor-type tyrosine-protein phosphatase-like N isoform X2

    UniProtKB/TrEMBL
    A0A8I5ZW92
  3. XM_063266535.1XP_063122605.1  receptor-type tyrosine-protein phosphatase-like N isoform X1

    UniProtKB/TrEMBL
    A0A8I5ZW92
  4. XM_063266536.1XP_063122606.1  receptor-type tyrosine-protein phosphatase-like N isoform X4

    UniProtKB/TrEMBL
    A0A8I6A9W6
  5. XM_063266538.1XP_063122608.1  receptor-type tyrosine-protein phosphatase-like N isoform X6

    UniProtKB/TrEMBL
    A0A8I6A9W6
  6. XM_063266537.1XP_063122607.1  receptor-type tyrosine-protein phosphatase-like N isoform X5

    UniProtKB/TrEMBL
    A0A8I6A9W6
  7. XM_006245134.5XP_006245196.1  receptor-type tyrosine-protein phosphatase-like N isoform X7

    UniProtKB/TrEMBL
    A0A8I6A9W6, A0A8L2QEF0
    Conserved Domains (5) summary
    smart00194
    Location:714973
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:741973
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    pfam06365
    Location:526650
    CD34_antigen; CD34/Podocalyxin family
    pfam11548
    Location:477562
    Receptor_IA-2; Protein-tyrosine phosphatase receptor IA-2
    pfam14948
    Location:66144
    RESP18; RESP18 domain
  8. XM_063266539.1XP_063122609.1  receptor-type tyrosine-protein phosphatase-like N isoform X8

    UniProtKB/TrEMBL
    A0A8I5ZW92
  9. XM_063266540.1XP_063122610.1  receptor-type tyrosine-protein phosphatase-like N isoform X9

    UniProtKB/TrEMBL
    A0A8I5ZW92
    Related
    ENSRNOP00000081951.1, ENSRNOT00000094318.2
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