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Lsm10 U7 snRNP-specific Sm-like protein LSM10 [ Mus musculus (house mouse) ]

Gene ID: 116748, updated on 30-Apr-2024

Summary

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Official Symbol
Lsm10provided by MGI
Official Full Name
U7 snRNP-specific Sm-like protein LSM10provided by MGI
Primary source
MGI:MGI:2151045
See related
Ensembl:ENSMUSG00000050188 AllianceGenome:MGI:2151045
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Enables histone pre-mRNA DCP binding activity. Predicted to be involved in mRNA 3'-end processing by stem-loop binding activity and cleavage and positive regulation of G1/S transition of mitotic cell cycle. Predicted to act upstream of or within RNA splicing and mRNA processing. Predicted to be located in Cajal body. Predicted to be part of U7 snRNP and cytoplasmic U snRNP body. Predicted to be active in nuclear body. Orthologous to human LSM10 (LSM10, U7 small nuclear RNA associated). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in subcutaneous fat pad adult (RPKM 18.4), mammary gland adult (RPKM 16.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
4 D2.2; 4 59.88 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125990350..125992375)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (126096562..126098584)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2121 Neighboring gene mitochondrial ribosomal protein S15 Neighboring gene STARR-positive B cell enhancer ABC_E3512 Neighboring gene organic solute carrier partner 1 Neighboring gene ribosomal protein L28, pseudogene 3 Neighboring gene STARR-positive B cell enhancer ABC_E2712 Neighboring gene STARR-positive B cell enhancer ABC_E2713 Neighboring gene serine/threonine kinase 40 Neighboring gene eva-1 homolog B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Purified U7 snRNPs lack the Sm proteins D1 and D2 but contain Lsm10, a new 14 kDa Sm D1-like protein. Pillai RS, et al. EMBO J, 2001 Oct 1. PMID 11574479, Free PMC Article
  2. Three proteins of the U7-specific Sm ring function as the molecular ruler to determine the site of 3'-end processing in mammalian histone pre-mRNA. Yang XC, et al. Mol Cell Biol, 2009 Aug. PMID 19470752, Free PMC Article
  3. Genome-wide expression profiling of mid-gestation placenta and embryo using a 15,000 mouse developmental cDNA microarray. Tanaka TS, et al. Proc Natl Acad Sci U S A, 2000 Aug 1. PMID 10922068, Free PMC Article
  4. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables U7 snRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables U7 snRNA binding ISO
Inferred from Sequence Orthology
more info
  
enables histone pre-mRNA DCP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone pre-mRNA DCP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables snRNA binding ISO
Inferred from Sequence Orthology
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA 3'-end processing by stem-loop binding and cleavage IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in Cajal body ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of U7 snRNP ISO
Inferred from Sequence Orthology
more info
 PubMed 
part_of cytoplasmic U snRNP body IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nuclear body IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U7 snRNA-associated Sm-like protein LSm10

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163266.2 → NP_001156738.1  U7 snRNA-associated Sm-like protein LSm10

    See identical proteins and their annotated locations for NP_001156738.1

    Status: VALIDATED

    Source sequence(s)
    AL627101
    Consensus CDS
    CCDS18642.1
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7
    Related
    ENSMUSP00000136585.2, ENSMUST00000179323.2
    Conserved Domains (1) summary
    cd01733
    Location:8 → 85
    LSm10; Like-Sm protein 10

  2. NM_001426132.1 → NP_001413061.1  U7 snRNA-associated Sm-like protein LSm10

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7

  3. NM_001426133.1 → NP_001413062.1  U7 snRNA-associated Sm-like protein LSm10

    Status: VALIDATED

    Source sequence(s)
    AL627101
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7

  4. NM_138721.3 → NP_620046.1  U7 snRNA-associated Sm-like protein LSm10

    See identical proteins and their annotated locations for NP_620046.1

    Status: VALIDATED

    Source sequence(s)
    AL627101
    Consensus CDS
    CCDS18642.1
    UniProtKB/Swiss-Prot
    Q8QZX5
    UniProtKB/TrEMBL
    Q3UPL7
    Related
    ENSMUSP00000061913.8, ENSMUST00000055575.8
    Conserved Domains (1) summary
    cd01733
    Location:8 → 85
    LSm10; Like-Sm protein 10

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    125990350..125992375
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QZX5.1 GenPept UniProtKB/Swiss-Prot:Q8QZX5

Gene LinkOut

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