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Kcns1 potassium voltage-gated channel, modifier subfamily S, member 1 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117023, updated on 11-Apr-2024

Summary

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Official Symbol
Kcns1provided by RGD
Official Full Name
potassium voltage-gated channel, modifier subfamily S, member 1provided by RGD
Primary source
RGD:621524
See related
Ensembl:ENSRNOG00000013681 AllianceGenome:RGD:621524
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Kv9.1
Summary
Predicted to enable delayed rectifier potassium channel activity and potassium channel regulator activity. Predicted to be involved in potassium ion transmembrane transport and regulation of delayed rectifier potassium channel activity. Predicted to be located in perinuclear region of cytoplasm and plasma membrane. Predicted to be part of voltage-gated potassium channel complex. Predicted to be integral component of membrane. Orthologous to human KCNS1 (potassium voltage-gated channel modifier subfamily S member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Brain (RPKM 17.3), Lung (RPKM 1.6) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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Location:
3q42
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (173255028..173262432, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (152835642..152843032, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (160554423..160561820, complement)

Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene translocase of outer mitochondrial membrane 34 Neighboring gene serine/threonine kinase 4 Neighboring gene uncharacterized LOC108350520 Neighboring gene WAP four-disulfide core domain 5 Neighboring gene WAP four-disulfide core domain 12

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Sensory neuron downregulation of the Kv9.1 potassium channel subunit mediates neuropathic pain following nerve injury. Tsantoulas C, et al. J Neurosci, 2012 Nov 28. PMID 23197740, Free PMC Article
  2. Cloning and tissue distribution of two new potassium channel alpha-subunits from rat brain. Stocker M, et al. Biochem Biophys Res Commun, 1998 Jul 30. PMID 9704029
  3. Electrically silent potassium channel subunits from human lens epithelium. Shepard AR, et al. Am J Physiol, 1999 Sep. PMID 10484328
  4. New modulatory alpha subunits for mammalian Shab K+ channels. Salinas M, et al. J Biol Chem, 1997 Sep 26. PMID 9305895
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables delayed rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables delayed rectifier potassium channel activity ISO
Inferred from Sequence Orthology
more info
  
enables delayed rectifier potassium channel activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables potassium channel regulator activity ISO
Inferred from Sequence Orthology
more info
  
enables potassium channel regulator activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in action potential IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transport ISO
Inferred from Sequence Orthology
more info
  
involved_in potassium ion transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein homooligomerization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of voltage-gated potassium channel complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of voltage-gated potassium channel complex ISO
Inferred from Sequence Orthology
more info
  
part_of voltage-gated potassium channel complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
potassium voltage-gated channel subfamily S member 1
Names
K+ voltage-gated channel, subfamily S, 1
delayed-rectifier K(+) channel alpha subunit 1
potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1
voltage-gated potassium channel subunit Kv9.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053954.2 → NP_446406.1  potassium voltage-gated channel subfamily S member 1

    See identical proteins and their annotated locations for NP_446406.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000003
    UniProtKB/Swiss-Prot
    O88758
    UniProtKB/TrEMBL
    A6JX60
    Related
    ENSRNOP00000018364.2, ENSRNOT00000018364.4
    Conserved Domains (4) summary
    smart00225
    Location:23 → 125
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:238 → 439
    Ion_trans; Ion transport protein
    pfam02214
    Location:21 → 120
    BTB_2; BTB/POZ domain
    pfam07885
    Location:355 → 433
    Ion_trans_2; Ion channel

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086021.1 Reference GRCr8

    Range
    173255028..173262432 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017591433.3 → XP_017446922.1  potassium voltage-gated channel subfamily S member 1 isoform X1

    UniProtKB/Swiss-Prot
    O88758
    UniProtKB/TrEMBL
    A6JX60
    Conserved Domains (4) summary
    smart00225
    Location:23 → 125
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:238 → 439
    Ion_trans; Ion transport protein
    pfam02214
    Location:21 → 120
    BTB_2; BTB/POZ domain
    pfam07885
    Location:355 → 433
    Ion_trans_2; Ion channel

  2. XM_006235509.5 → XP_006235571.1  potassium voltage-gated channel subfamily S member 1 isoform X1

    See identical proteins and their annotated locations for XP_006235571.1

    UniProtKB/Swiss-Prot
    O88758
    UniProtKB/TrEMBL
    A6JX60
    Conserved Domains (4) summary
    smart00225
    Location:23 → 125
    BTB; Broad-Complex, Tramtrack and Bric a brac
    pfam00520
    Location:238 → 439
    Ion_trans; Ion transport protein
    pfam02214
    Location:21 → 120
    BTB_2; BTB/POZ domain
    pfam07885
    Location:355 → 433
    Ion_trans_2; Ion channel
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O88758.1 GenPept UniProtKB/Swiss-Prot:O88758

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