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Rab28 RAB28, member RAS oncogene family [ Rattus norvegicus (Norway rat) ]

Gene ID: 117049, updated on 8-Mar-2024

Summary

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Official Symbol
Rab28provided by RGD
Official Full Name
RAB28, member RAS oncogene familyprovided by RGD
Primary source
RGD:620891
See related
Ensembl:ENSRNOG00000017074 AllianceGenome:RGD:620891
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Enables GTP binding activity. Predicted to be involved in intracellular protein transport. Predicted to act upstream of or within toxin transport. Located in ciliary basal body and ciliary rootlet. Human ortholog(s) of this gene implicated in cone-rod dystrophy 18. Orthologous to human RAB28 (RAB28, member RAS oncogene family). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Muscle (RPKM 170.7), Heart (RPKM 161.4) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Rab28 in Genome Data Viewer
Location:
14q21
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 14 NC_086032.1 (73458386..73535367)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 14 NC_051349.1 (69245846..69322968)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 14 NC_005113.4 (73888968..73963209)

Chromosome 14 - NC_086032.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550431 Neighboring gene uncharacterized LOC120096626 Neighboring gene RNA polymerase III subunit F, pseudogene 1 Neighboring gene clusterin associated protein 1, pseudogene 2 Neighboring gene developmental pluripotency-associated protein 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Mutations in RAB28, encoding a farnesylated small GTPase, are associated with autosomal-recessive cone-rod dystrophy. Roosing S, et al. Am J Hum Genet, 2013 Jul 11. PMID 23746546, Free PMC Article
  2. Involvement of Rab28 in NF-κB nuclear transport in endothelial cells. Jiang J, et al. PLoS One, 2013. PMID 23457503, Free PMC Article
  3. Large nucleotide-dependent conformational change in Rab28. Lee SH, et al. FEBS Lett, 2008 Dec 10. PMID 19026641, Free PMC Article
  4. Alternative mRNA splicing of the novel GTPase Rab28 generates isoforms with different C-termini. Brauers A, et al. Eur J Biochem, 1996 May 1. PMID 8647132
  5. CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells. Slater LH, et al. Proc Natl Acad Sci U S A, 2013 Jun 11. PMID 23716698, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab28 is novel regulator of NFkB nuclear transport in endothelial cells.
    Title: Involvement of Rab28 in NF-κB nuclear transport in endothelial cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in ciliary rootlet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in endomembrane system IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ras-related protein Rab-28
Names
rab-26
NP_446430.1
XP_008768417.1
XP_008768418.1
XP_008768419.1
XP_008768420.1
XP_017454543.1
XP_063128875.1
XP_063128876.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053978.1 → NP_446430.1  ras-related protein Rab-28

    See identical proteins and their annotated locations for NP_446430.1

    Status: PROVISIONAL

    Source sequence(s)
    X78606
    UniProtKB/Swiss-Prot
    P51158
    UniProtKB/TrEMBL
    A6IJR0, A6IJR3
    Related
    ENSRNOP00000071725.1, ENSRNOT00000081033.2
    Conserved Domains (1) summary
    cd04109
    Location:13 → 221
    Rab28; Rab GTPase family 28 (Rab28)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086032.1 Reference GRCr8

    Range
    73458386..73535367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_008770196.3 → XP_008768418.1  ras-related protein Rab-28 isoform X1

    See identical proteins and their annotated locations for XP_008768418.1

    UniProtKB/TrEMBL
    A6IJR0, Q6IN03
    Conserved Domains (1) summary
    cd04109
    Location:13 → 220
    Rab28; Rab GTPase family 28 (Rab28)

  2. XM_017599054.3 → XP_017454543.1  ras-related protein Rab-28 isoform X5

    UniProtKB/TrEMBL
    A6IJR0, A6IJR1
    Conserved Domains (2) summary
    smart00175
    Location:13 → 178
    RAB; Rab subfamily of small GTPases
    cl21455
    Location:13 → 191
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  3. XM_008770198.3 → XP_008768420.1  ras-related protein Rab-28 isoform X4

    See identical proteins and their annotated locations for XP_008768420.1

    UniProtKB/TrEMBL
    A0A8I5ZQN9, A6IJQ9, A6IJR0
    Related
    ENSRNOP00000080796.1
    Conserved Domains (1) summary
    cl38936
    Location:13 → 193
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. XM_008770195.3 → XP_008768417.1  ras-related protein Rab-28 isoform X1

    See identical proteins and their annotated locations for XP_008768417.1

    UniProtKB/TrEMBL
    A6IJR0, Q6IN03
    Related
    ENSRNOP00000050260.2
    Conserved Domains (1) summary
    cd04109
    Location:13 → 220
    Rab28; Rab GTPase family 28 (Rab28)

  5. XM_063272805.1 → XP_063128875.1  ras-related protein Rab-28 isoform X3

  6. XM_008770197.4 → XP_008768419.1  ras-related protein Rab-28 isoform X2

    UniProtKB/TrEMBL
    A0A8I6GGV5
    Conserved Domains (2) summary
    smart00175
    Location:16 → 170
    RAB; Rab subfamily of small GTPases
    cd04109
    Location:16 → 213
    Rab28; Rab GTPase family 28 (Rab28)

  7. XM_063272806.1 → XP_063128876.1  ras-related protein Rab-28 isoform X6

RNA

  1. XR_005492875.2 RNA Sequence

  2. XR_005492878.2 RNA Sequence

  3. XR_005492874.2 RNA Sequence

  4. XR_005492877.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P51158.1 GenPept UniProtKB/Swiss-Prot:P51158

Gene LinkOut

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