U.S. flag

An official website of the United States government

Vip vasoactive intestinal peptide [ Rattus norvegicus (Norway rat) ]

Gene ID: 117064, updated on 4-Jan-2025

Summary

Official Symbol
Vipprovided by RGD
Official Full Name
vasoactive intestinal peptideprovided by RGD
Primary source
RGD:621647
See related
EnsemblRapid:ENSRNOG00000018808 AllianceGenome:RGD:621647
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
vip/phi27
Summary
Enables hormone activity. Involved in several processes, including negative regulation of smooth muscle cell proliferation; positive regulation of endothelial cell proliferation; and positive regulation of penile erection. Located in neuronal cell body. Used to study several diseases, including Parkinsonism; brain ischemia; periodontitis; pulmonary hypertension; and uveitis. Biomarker of visual epilepsy. Human ortholog(s) of this gene implicated in alcohol use disorder and pulmonary sarcoidosis. Orthologous to human VIP (vasoactive intestinal peptide). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Biased expression in Brain (RPKM 54.8), Adrenal (RPKM 4.2) and 1 other tissue See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Vip in Genome Data Viewer
Location:
1q11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (44470232..44478561)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (42064878..42073219)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (42169307..42177582)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene spectrin repeat containing nuclear envelope protein 1 Neighboring gene RNA, U6 small nuclear 959 Neighboring gene myc target 1 Neighboring gene uncharacterized LOC120097707 Neighboring gene F-box protein 5

Genomic regions, transcripts, and products

Expression

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables hormone activity PubMed 
enables hormone activity  
enables neuropeptide hormone activity  
enables neuropeptide hormone activity  
enables neuropeptide hormone activity  
enables neuropeptide hormone activity  
enables peptide hormone receptor binding  
enables peptide hormone receptor binding  
enables peptide hormone receptor binding  
enables signaling receptor binding PubMed 
enables type 1 vasoactive intestinal polypeptide receptor binding  
enables type 1 vasoactive intestinal polypeptide receptor binding  
enables type 2 vasoactive intestinal polypeptide receptor binding  
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
involved_in antimicrobial humoral immune response mediated by antimicrobial peptide  
involved_in epinephrine secretion  
involved_in innate immune response  
involved_in learning or memory PubMed 
involved_in mRNA stabilization  
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of potassium ion transport PubMed 
involved_in negative regulation of smooth muscle cell proliferation PubMed 
involved_in positive regulation of endothelial cell proliferation PubMed 
involved_in positive regulation of penile erection PubMed 
involved_in positive regulation of protein catabolic process PubMed 
involved_in positive regulation of protein catabolic process  
involved_in positive regulation of protein catabolic process  
involved_in prolactin secretion  
involved_in regulation of protein localization  
involved_in regulation of protein localization PubMed 
involved_in regulation of protein localization  
involved_in regulation of protein localization  
acts_upstream_of_or_within regulation of signal transduction  
Component Evidence Code Pubs
located_in extracellular region  
is_active_in extracellular space  
is_active_in neuron projection  
located_in neuron projection terminus  
located_in neuronal cell body PubMed 

General protein information

Preferred Names
VIP peptides
Names
vasoactive intestinal polypeptide

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053991.1 → NP_446443.1  VIP peptides preproprotein

    See identical proteins and their annotated locations for NP_446443.1

    Status: VALIDATED

    Source sequence(s)
    BC158798, CB583853
    UniProtKB/Swiss-Prot
    P01283, Q9QUN1
    UniProtKB/TrEMBL
    A0A090AX27, A0A090BZQ0, A0A1B0GWR8, A6KIN8
    Related
    ENSRNOP00000025477.6, ENSRNOT00000025477.8
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 108
    Hormone_2; Peptide hormone

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    44470232..44478561
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039078200.2 → XP_038934128.1  VIP peptides isoform X3

    UniProtKB/TrEMBL
    A0A1B0GWR8
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 108
    Hormone_2; Peptide hormone
  2. XM_017588692.3 → XP_017444181.1  VIP peptides isoform X1

    UniProtKB/TrEMBL
    A0A1B0GWR8, B0BNF3
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 107
    Hormone_2; Peptide hormone
  3. XM_017588691.3 → XP_017444180.1  VIP peptides isoform X2

    UniProtKB/TrEMBL
    A0A1B0GWR8
    Conserved Domains (1) summary
    pfam00123
    Location:81 → 107
    Hormone_2; Peptide hormone
External link. Please review our privacy policy.