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Dnah3 dynein, axonemal, heavy chain 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117249, updated on 13-Apr-2024

Summary

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Symbol
Dnah3provided by RGD
Full Name
dynein, axonemal, heavy chain 3provided by RGD
Primary source
RGD:1305855
See related
Ensembl:ENSRNOG00000050426 AllianceGenome:RGD:1305855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Dnahc3; Dnahc3l; AABR07005597.1
Summary
Orthologous to human DNAH3 (dynein axonemal heavy chain 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 51.0), Testes (RPKM 47.7) and 2 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
1q35-q36
Exon count:
62
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (183738013..183910831, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (174305929..174479490, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (189708985..189865431, complement)

Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene ERI1 exoribonuclease family member 2 Neighboring gene RNA exonuclease 5 Neighboring gene defective in cullin neddylation 1 domain containing 3 Neighboring gene LYR motif containing 1 Neighboring gene U6 spliceosomal RNA Neighboring gene uncharacterized LOC120099919 Neighboring gene replication protein A3, pseudogene 1 Neighboring gene lipid droplet assembly factor 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 4B Neighboring gene zona pellucida glycoprotein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712
  2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein axonemal heavy chain 3
Names
dynein heavy chain 3, axonemal-like
dynein, axonemal, heavy polypeptide 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001427640.1 → NP_001414569.1  dynein axonemal heavy chain 3

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000001
    UniProtKB/TrEMBL
    A0A8I6GLR7

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086019.1 Reference GRCr8

    Range
    183738013..183910831 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039101168.2 → XP_038957096.1  dynein axonemal heavy chain 3 isoform X1

    UniProtKB/TrEMBL
    A0A8I6GLR7
    Related
    ENSRNOP00000095701.1
    Conserved Domains (5) summary
    COG5245
    Location:1015 → 3762
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:812 → 1218
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1344 → 1670
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2357 → 2617
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:3764 → 4065
    Dynein_C; Dynein heavy chain C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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