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Dnah10 dynein, axonemal, heavy chain 10 [ Rattus norvegicus (Norway rat) ]

Gene ID: 117252, updated on 2-May-2024

Summary

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Official Symbol
Dnah10provided by RGD
Official Full Name
dynein, axonemal, heavy chain 10provided by RGD
Primary source
RGD:619988
See related
Ensembl:ENSRNOG00000052704 AllianceGenome:RGD:619988
Gene type
protein coding
RefSeq status
MODEL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Human ortholog(s) of this gene implicated in spermatogenic failure. Orthologous to human DNAH10 (dynein axonemal heavy chain 10). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Lung (RPKM 39.6), Testes (RPKM 39.1) and 1 other tissue See more
Orthologs
human mouse all
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Genomic context

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See Dnah10 in Genome Data Viewer
Location:
12q15
Exon count:
80
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 12 NC_086030.1 (37484444..37607810, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 12 NC_051347.1 (31823451..31946857, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 12 NC_005111.4 (37237482..37365258, complement)

Chromosome 12 - NC_086030.1Genomic Context describing neighboring genes Neighboring gene zinc finger protein 664 Neighboring gene ribosomal protein L27 like 5 Neighboring gene coiled-coil domain containing 92 Neighboring gene eukaryotic translation initiation factor 1 pseudogene Neighboring gene uncharacterized LOC120095966 Neighboring gene ATPase H+ transporting V0 subunit a2 Neighboring gene uncharacterized LOC134481292 Neighboring gene tectonic family member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Identification and molecular evolution of new dynein-like protein sequences in rat brain. Tanaka Y, et al. J Cell Sci, 1995 May. PMID 7657712

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables dynein intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables dynein light intermediate chain binding IEA
Inferred from Electronic Annotation
more info
  
enables minus-end-directed microtubule motor activity IEA
Inferred from Electronic Annotation
more info
  
enables proton-transporting ATPase activity, rotational mechanism IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in microtubule-based movement IEA
Inferred from Electronic Annotation
more info
  
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in axoneme IEA
Inferred from Electronic Annotation
more info
  
part_of dynein complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
dynein heavy chain 10, axonemal; dynein axonemal heavy chain 10
Names
dynein, axonemal, heavy polypeptide 10

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086030.1 Reference GRCr8

    Range
    37484444..37607810 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039090119.2 → XP_038946047.1  dynein axonemal heavy chain 10 isoform X2

    UniProtKB/TrEMBL
    A0A8I6A269
    Conserved Domains (6) summary
    COG5245
    Location:1615 → 4233
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:308 → 878
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1374 → 1779
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1914 → 2240
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2893 → 3152
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:4290 → 4588
    Dynein_C; Dynein heavy chain C-terminal domain

  2. XM_008769272.4 → XP_008767494.2  dynein axonemal heavy chain 10 isoform X1

    UniProtKB/TrEMBL
    A0A8I6A269, A0A8I6GMJ7
    Related
    ENSRNOP00000097523.1
    Conserved Domains (6) summary
    COG5245
    Location:1616 → 4234
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:309 → 879
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:1375 → 1780
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1915 → 2241
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2894 → 3153
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:4291 → 4589
    Dynein_C; Dynein heavy chain C-terminal domain

  3. XM_039090122.2 → XP_038946050.1  dynein axonemal heavy chain 10 isoform X3

    UniProtKB/TrEMBL
    A0A8I6A269
    Conserved Domains (6) summary
    COG5245
    Location:1086 → 3704
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08385
    Location:1 → 349
    DHC_N1; Dynein heavy chain, N-terminal region 1
    pfam08393
    Location:845 → 1250
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:1385 → 1711
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:2364 → 2623
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:3761 → 4059
    Dynein_C; Dynein heavy chain C-terminal domain

  4. XM_039090123.2 → XP_038946051.1  dynein axonemal heavy chain 10 isoform X4

    Conserved Domains (5) summary
    COG5245
    Location:374 → 2992
    DYN1; Dynein, heavy chain [Cytoskeleton]
    pfam08393
    Location:133 → 538
    DHC_N2; Dynein heavy chain, N-terminal region 2
    pfam12774
    Location:673 → 999
    AAA_6; Hydrolytic ATP binding site of dynein motor region D1
    pfam12780
    Location:1652 → 1911
    AAA_8; P-loop containing dynein motor region D4
    pfam18199
    Location:3049 → 3347
    Dynein_C; Dynein heavy chain C-terminal domain

RNA

  1. XR_005491954.2 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version

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