Baiap2 BAR/IMD domain containing adaptor protein 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Baiap2provided by RGD
Full Name: BAR/IMD domain containing adaptor protein 2provided by RGD
Primary source: RGD:619814
See related: Ensembl:ENSRNOG00000004049 AllianceGenome:RGD:619814
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Irsp53
Summary: Enables PDZ domain binding activity; scaffold protein binding activity; and transcription coregulator binding activity. Involved in several processes, including cellular response to L-glutamate; nervous system development; and regulation of synapse organization. Located in several cellular components, including dendrite; lamellipodium; and neuron projection branch point. Is active in several cellular components, including postsynaptic cytosol; postsynaptic density, intracellular component; and presynaptic cytosol. Colocalizes with postsynaptic density. Human ortholog(s) of this gene implicated in Gilles de la Tourette syndrome; attention deficit hyperactivity disorder; and autism spectrum disorder. Orthologous to human BAIAP2 (BAR/IMD domain containing adaptor protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 147.4), Testes (RPKM 73.9) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.3

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (105721371..105788549)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (105223065..105290130)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (109107326..109187458)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-kappaB and Impaired Mobility of HUVECs.
Title: Insulin Receptor Substrate p53 Ameliorates High-Glucose-Induced Activation of NF-κB and Impaired Mobility of HUVECs.
IRSp53 molecules may have a structural role organizing the Shank scaffold and/or linking the PSD to the actin cytoskeleton
Title: IRSp53 accumulates at the postsynaptic density under excitatory conditions.
These findings suggest that SH2B1-IRSp53 complexes promote the formation of filopodia, neurite initiation, and neuronal branching.
Title: SH2B1 and IRSp53 proteins promote the formation of dendrites and dendritic branches.
Localization study of IRSp53 in the adult brain, suggesting that it acts mainly at the postsynaptic density, that it may play a role in the insulin signaling system, and that it may play different roles in different synapses
Title: Postsynaptic distribution of IRSp53 in spiny excitatory and inhibitory neurons.
IRSp53/N-WASP interaction is regulated by TGFbeta3 and is involved in regulation of filopodial formation and cell adhesion.
Title: The type III TGFβ receptor regulates filopodia formation via a Cdc42-mediated IRSp53-N-WASP interaction in epithelial cells.
ProSAP/Shank and certain ProSAP/Shank-interacting proteins exhibit distinct subcellular localizations in the different cell types, raising the possibility that the function of ProSAP/Shank proteins is more diverse than has been envisaged to date.
Title: Secretory granules of hypophyseal and pancreatic endocrine cells contain proteins of the neuronal postsynaptic density.
These results suggest that PSD-95 interaction is an important determinant of synaptic IRSp53 localization and that the SH3 domain of IRSp53 links activated Rac1/Cdc42 to downstream effectors for the regulation of spine morphogenesis.
Title: Regulation of dendritic spine morphogenesis by insulin receptor substrate 53, a downstream effector of Rac1 and Cdc42 small GTPases.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D11Mit298.5 (e-PCR), detects polymorphism
- UniSTS:126507

BE292689 (e-PCR)
- UniSTS:209201

RH127793 (e-PCR)
- UniSTS:211103

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables PDZ domain binding	IDA Inferred from Direct Assay more info	PubMed
enables cytoskeletal anchor activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISO Inferred from Sequence Orthology more info
enables proline-rich region binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables scaffold protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin crosslink formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin crosslink formation	ISO Inferred from Sequence Orthology more info
involved_in actin crosslink formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in actin filament bundle assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISO Inferred from Sequence Orthology more info
involved_in actin filament bundle assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to L-glutamate	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to epidermal growth factor stimulus	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within dendrite development	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in neuron differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in plasma membrane organization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of actin filament polymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of excitatory postsynaptic potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of neuron projection development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in regulation of actin cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in regulation of actin cytoskeleton organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell shape	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell shape	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in Schaffer collateral - CA1 synapse	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in actin cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic shaft	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
located_in dendritic spine cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in excitatory synapse	IDA Inferred from Direct Assay more info	PubMed
located_in filopodium	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in lamellipodium	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in microtubule	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection	ISO Inferred from Sequence Orthology more info
located_in neuron projection branch point	IDA Inferred from Direct Assay more info	PubMed
located_in neuron projection terminus	IDA Inferred from Direct Assay more info	PubMed
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic density, intracellular component	IDA Inferred from Direct Assay more info	PubMed
located_in presynapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in presynaptic cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in ruffle	IEA Inferred from Electronic Annotation more info
located_in secretory granule	IDA Inferred from Direct Assay more info	PubMed
located_in synaptic membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: brain-specific angiogenesis inhibitor 1-associated protein 2

Names: BAI-associated protein 2; BAI1-associated protein 2; brain-specific angiogenesis inhibitor 1-associated protein 2-like; insulin receptor substrate 53; insulin receptor substrate p53; insulin receptor substrate protein of 53 kDa; insulin receptor tyrosine kinase substrate protein p53

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057196.1 → NP_476544.1 brain-specific angiogenesis inhibitor 1-associated protein 2

See identical proteins and their annotated locations for NP_476544.1

Status: PROVISIONAL

Source sequence(s)

AY037934

UniProtKB/TrEMBL

A0A8I6GJY9, A6HLA2, A6HLA3

Related

ENSRNOP00000060172.3, ENSRNOT00000068437.5

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:378 → 436

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

105721371..105788549

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247872.4 → XP_006247934.1 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X4

UniProtKB/TrEMBL

A0A8I6GJY9, A6HLA3

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:338 → 396

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_006247869.5 → XP_006247931.1 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X1

See identical proteins and their annotated locations for XP_006247931.1

UniProtKB/Swiss-Prot

Q6GMN2, Q923H3

UniProtKB/TrEMBL

A0A8I6GJY9, A6HLA0, A6HLA3

Related

ENSRNOP00000005687.6

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:378 → 436

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_006247871.4 → XP_006247933.1 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X3

UniProtKB/TrEMBL

A0A8I6GJY9, A6HLA3

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:338 → 396

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_006247870.4 → XP_006247932.1 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X2

See identical proteins and their annotated locations for XP_006247932.1

UniProtKB/TrEMBL

A0A8I6A2M9, A0A8I6GJY9, A6HLA1, A6HLA3

Related

ENSRNOP00000084785.1

Conserved Domains (2) summary

cd07646
Location:5 → 236

I-BAR_IMD_IRSp53; Inverse (I)-BAR, also known as the IRSp53/MIM homology Domain (IMD), of Insulin Receptor tyrosine kinase Substrate p53

cd11915
Location:378 → 436

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53
XM_039085085.2 → XP_038941013.1 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X5

UniProtKB/TrEMBL

A0A8I6GJY9, A6HLA3

Conserved Domains (2) summary

cd11915
Location:320 → 378

SH3_Irsp53; Src Homology 3 domain of Insulin Receptor tyrosine kinase Substrate p53

cl12013
Location:1 → 178

BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
XM_063268340.1 → XP_063124410.1 brain-specific angiogenesis inhibitor 1-associated protein 2 isoform X6