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Apoc3 apolipoprotein C-III [ Mus musculus (house mouse) ]

Gene ID: 11814, updated on 4-Jan-2025

Summary

Official Symbol
Apoc3provided by MGI
Official Full Name
apolipoprotein C-IIIprovided by MGI
Primary source
MGI:MGI:88055
See related
Ensembl:ENSMUSG00000032081 AllianceGenome:MGI:88055
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
apo-CIII; apoC-III
Summary
This gene encodes an apolipoprotein which is the major protein component of very-low-density lipoproteins (VLDL) and a minor component of high-density lipoproteins (HDL). The encoded protein is thought to regulate the metabolism of triglyceride-rich lipoproteins and play a role in lipid storage and the mobilization of fat cells. This gene is clustered with three other apolipoprotein genes on chromosome 9 and is associated with coronary disease. Mice lacking this gene have lower levels of total cholesterol in the plasma. Mutations in the human genes causes hyperalphalipoproteinemia 2, a disorder of lipid metabolism which results in a favorable lipid profile (lower LDL-cholesterol, higher HDL-cholesterol and lower levels of serum triglycerides when fasting and after a meal). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in liver adult (RPKM 1808.2), duodenum adult (RPKM 768.1) and 2 other tissues See more
Orthologs
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Genomic context

See Apoc3 in Genome Data Viewer
Location:
9 A5.2; 9 25.36 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (46144348..46146934, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (46233050..46235636, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene SIK family kinase 3 Neighboring gene POU domain, class 5, transcription factor 1, related sequence 9 Neighboring gene STARR-seq mESC enhancer starr_24022 Neighboring gene apolipoprotein A-I Neighboring gene STARR-seq mESC enhancer starr_24024 Neighboring gene apolipoprotein A-IV Neighboring gene apolipoprotein A-V

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (4)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme regulator activity  
enables high-density lipoprotein particle receptor binding  
enables high-density lipoprotein particle receptor binding  
enables lipase inhibitor activity  
enables lipase inhibitor activity  
enables lipid binding  
enables phospholipid binding  
enables phospholipid binding  
Items 1 - 25 of 39
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway  
involved_in cellular response to glucose stimulus  
involved_in cholesterol efflux  
involved_in cholesterol homeostasis  
involved_in cholesterol homeostasis  
acts_upstream_of_or_within cholesterol metabolic process PubMed 
involved_in chylomicron remnant clearance  
involved_in high-density lipoprotein particle remodeling  
involved_in lipid transport  
involved_in lipoprotein metabolic process  
involved_in lipoprotein transport  
involved_in negative regulation of cholesterol import  
involved_in negative regulation of fatty acid biosynthetic process  
involved_in negative regulation of high-density lipoprotein particle clearance  
involved_in negative regulation of high-density lipoprotein particle clearance  
involved_in negative regulation of lipid catabolic process  
involved_in negative regulation of lipid metabolic process  
involved_in negative regulation of lipoprotein lipase activity  
involved_in negative regulation of low-density lipoprotein particle clearance  
involved_in negative regulation of low-density lipoprotein particle clearance  
involved_in negative regulation of oxidative phosphorylation  
involved_in negative regulation of receptor-mediated endocytosis  
involved_in negative regulation of triglyceride catabolic process  
involved_in negative regulation of triglyceride catabolic process  
involved_in negative regulation of very-low-density lipoprotein particle clearance  
involved_in negative regulation of very-low-density lipoprotein particle clearance  
involved_in negative regulation of very-low-density lipoprotein particle remodeling  
involved_in phospholipid efflux  
involved_in positive regulation of triglyceride biosynthetic process  
involved_in regulation of Cdc42 protein signal transduction  
involved_in response to peptide hormone  
involved_in triglyceride catabolic process  
acts_upstream_of_or_within triglyceride catabolic process PubMed 
involved_in triglyceride catabolic process  
involved_in triglyceride homeostasis  
involved_in triglyceride homeostasis  
acts_upstream_of_or_within triglyceride metabolic process PubMed 
involved_in triglyceride metabolic process  
acts_upstream_of_or_within triglyceride mobilization PubMed 
Items 1 - 25 of 39
Component Evidence Code Pubs
part_of chylomicron  
part_of chylomicron  
part_of chylomicron  
located_in cytosol  
located_in extracellular region  
located_in extracellular space  
part_of intermediate-density lipoprotein particle  
part_of intermediate-density lipoprotein particle  
part_of spherical high-density lipoprotein particle  
part_of spherical high-density lipoprotein particle  
part_of very-low-density lipoprotein particle  
part_of very-low-density lipoprotein particle  
part_of very-low-density lipoprotein particle  

General protein information

Preferred Names
apolipoprotein C-III
Names
apolipoprotein C3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289755.1NP_001276684.1  apolipoprotein C-III isoform a precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).
    Source sequence(s)
    AC116503
    Consensus CDS
    CCDS80989.1
    UniProtKB/TrEMBL
    E9QP56
    Related
    ENSMUSP00000113126.2, ENSMUST00000121916.8
    Conserved Domains (1) summary
    pfam05778
    Location:61128
    Apo-CIII; Apolipoprotein CIII (Apo-CIII)
  2. NM_001289756.1NP_001276685.1  apolipoprotein C-III isoform b precursor

    See identical proteins and their annotated locations for NP_001276685.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the use of an alternate promoter, differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC116503, AK008260, W61891
    Consensus CDS
    CCDS23141.1
    UniProtKB/Swiss-Prot
    P33622, Q8VC58, Q9CPP9
    UniProtKB/TrEMBL
    A0A0R4J1N3
    Related
    ENSMUSP00000113058.2, ENSMUST00000118649.8
    Conserved Domains (1) summary
    pfam05778
    Location:2390
    Apo-CIII; Apolipoprotein CIII (Apo-CIII)
  3. NM_001289833.1NP_001276762.1  apolipoprotein C-III isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (c) has a shorter N-terminus compared to isoform a.
    Source sequence(s)
    AC116503
    Related
    ENSMUST00000214729.2
    Conserved Domains (1) summary
    pfam05778
    Location:155
    Apo-CIII; Apolipoprotein CIII (Apo-CIII)
  4. NM_023114.4NP_075603.1  apolipoprotein C-III isoform b precursor

    See identical proteins and their annotated locations for NP_075603.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon compared to variant 1. The encoded isoform (b) has a shorter N-terminus compared to isoform a. Variants 2 and 3 encode the same protein.
    Source sequence(s)
    AC116503, AK008260
    Consensus CDS
    CCDS23141.1
    UniProtKB/Swiss-Prot
    P33622, Q8VC58, Q9CPP9
    UniProtKB/TrEMBL
    A0A0R4J1N3
    Related
    ENSMUSP00000034586.3, ENSMUST00000034586.9
    Conserved Domains (1) summary
    pfam05778
    Location:2390
    Apo-CIII; Apolipoprotein CIII (Apo-CIII)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    46144348..46146934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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