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Nr2f2 nuclear receptor subfamily 2, group F, member 2 [ Mus musculus (house mouse) ]

Gene ID: 11819, updated on 14-Jan-2025

Summary

Official Symbol
Nr2f2provided by MGI
Official Full Name
nuclear receptor subfamily 2, group F, member 2provided by MGI
Primary source
MGI:MGI:1352452
See related
Ensembl:ENSMUSG00000030551 AllianceGenome:MGI:1352452
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
EAR3; ARP-1; SVP40; Aporp1; COUPTFB; COUP-TF2; Tcfcoup2; COUP-TFII; 2700033K02Rik; 9430015G03Rik
Summary
Enables sequence-specific DNA binding activity. Involved in lymph vessel development. Acts upstream of or within several processes, including blood vessel development; nervous system development; and regionalization. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study congenital diaphragmatic hernia and dilated cardiomyopathy. Human ortholog(s) of this gene implicated in 46,XX sex reversal 5. Orthologous to human NR2F2 (nuclear receptor subfamily 2 group F member 2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in ovary adult (RPKM 38.4), adrenal adult (RPKM 29.8) and 25 other tissues See more
Orthologs
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Genomic context

See Nr2f2 in Genome Data Viewer
Location:
7 C; 7 38.66 cM
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (70001694..70016494, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (70351946..70366746, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 29683 Neighboring gene predicted gene, 35271 Neighboring gene predicted gene, 35325 Neighboring gene STARR-seq mESC enhancer starr_19131 Neighboring gene RIKEN cDNA B130024G19 gene Neighboring gene STARR-seq mESC enhancer starr_19132 Neighboring gene predicted gene 28258 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (7)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding PubMed 
enables DNA-binding transcription factor activity  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding  
enables nuclear receptor activity  
enables nuclear receptor activity  
enables nuclear receptor activity  
enables protein homodimerization activity  
enables protein homodimerization activity  
enables retinoic acid binding  
enables retinoic acid binding  
enables retinoic acid binding  
enables sequence-specific DNA binding PubMed 
enables sequence-specific DNA binding  
enables zinc ion binding  
Items 1 - 25 of 38
Process Evidence Code Pubs
acts_upstream_of_or_within anterior/posterior pattern specification PubMed 
acts_upstream_of_or_within blood vessel morphogenesis PubMed 
involved_in cell differentiation  
involved_in female gonad development  
involved_in female gonad development  
acts_upstream_of_or_within fertilization PubMed 
acts_upstream_of_or_within forebrain development PubMed 
acts_upstream_of_or_within in utero embryonic development PubMed 
acts_upstream_of_or_within interneuron migration PubMed 
involved_in intracellular receptor signaling pathway  
involved_in lymph vessel development PubMed 
involved_in lymphatic endothelial cell fate commitment  
involved_in lymphatic endothelial cell fate commitment  
acts_upstream_of_or_within maternal placenta development PubMed 
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity  
involved_in negative regulation of endothelial cell migration  
involved_in negative regulation of endothelial cell migration  
involved_in negative regulation of endothelial cell proliferation  
involved_in negative regulation of endothelial cell proliferation  
involved_in negative regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II PubMed 
involved_in negative regulation of transcription by RNA polymerase II  
involved_in nervous system development  
acts_upstream_of_or_within neuron migration PubMed 
acts_upstream_of_or_within placenta blood vessel development PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of systemic arterial blood pressure  
involved_in positive regulation of systemic arterial blood pressure  
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of transcription by RNA polymerase II  
acts_upstream_of_or_within radial pattern formation PubMed 
involved_in regulation of DNA-templated transcription  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II PubMed 
involved_in response to estradiol  
acts_upstream_of_or_within skeletal muscle tissue development PubMed 
acts_upstream_of_or_within trophoblast giant cell differentiation PubMed 
Items 1 - 25 of 38
Component Evidence Code Pubs
located_in cytosol  
located_in cytosol  
located_in nucleoplasm  
located_in nucleoplasm  
located_in nucleus PubMed 
located_in nucleus  

General protein information

Preferred Names
COUP transcription factor 2
Names
COUP transcription factor II
COUP-TF II
apolipoprotein AI regulatory protein 1
apolipoprotein regulatory protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009697.3NP_033827.2  COUP transcription factor 2 isoform 1

    See identical proteins and their annotated locations for NP_033827.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC125317, BC042484, BC094360
    Consensus CDS
    CCDS21359.1
    UniProtKB/Swiss-Prot
    P43135, Q60632, Q61438
    UniProtKB/TrEMBL
    Q3UST6
    Related
    ENSMUSP00000032768.8, ENSMUST00000032768.15
    Conserved Domains (2) summary
    cd06948
    Location:177411
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
    cd06958
    Location:79151
    NR_DBD_COUP_TF; DNA-binding domain of chicken ovalbumin upstream promoter transcription factors (COUP-TFs) is composed of two C4-type zinc fingers
  2. NM_183261.3NP_899084.2  COUP transcription factor 2 isoform 2

    See identical proteins and their annotated locations for NP_899084.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents use of an alternate promoter and differs in the 5' UTR and 5' coding region compared to variant 1. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC125317, BC094360, BY001758
    Consensus CDS
    CCDS21358.1
    UniProtKB/TrEMBL
    D3YYP4
    Related
    ENSMUSP00000086993.6, ENSMUST00000089565.6
    Conserved Domains (1) summary
    cd06948
    Location:44278
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    70001694..70016494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540578.2XP_006540641.1  COUP transcription factor 2 isoform X2

    See identical proteins and their annotated locations for XP_006540641.1

    Conserved Domains (1) summary
    cd06948
    Location:24258
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
  2. XM_006540577.5XP_006540640.1  COUP transcription factor 2 isoform X1

    See identical proteins and their annotated locations for XP_006540640.1

    Conserved Domains (1) summary
    cd06948
    Location:34268
    NR_LBD_COUP-TF; Ligand binding domain of chicken ovalbumin upstream promoter transcription factors, a member of the nuclear receptor family
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