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Aqp1 aquaporin 1 [ Mus musculus (house mouse) ]

Gene ID: 11826, updated on 13-Jan-2025

Summary

Official Symbol
Aqp1provided by MGI
Official Full Name
aquaporin 1provided by MGI
Primary source
MGI:MGI:103201
See related
Ensembl:ENSMUSG00000004655 AllianceGenome:MGI:103201
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHIP28
Summary
Enables ephrin receptor binding activity; potassium ion transmembrane transporter activity; and water transmembrane transporter activity. Involved in several processes, including defense response to Gram-negative bacterium; lateral ventricle development; and metanephros development. Acts upstream of or within several processes, including corticotropin secretion; glomerular filtration; and renal water absorption. Located in several cellular components, including basolateral plasma membrane; brush border; and extracellular exosome. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; sensory organ; and skeleton. Orthologous to human AQP1 (aquaporin 1 (Colton blood group)). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in kidney adult (RPKM 483.5), lung adult (RPKM 456.4) and 19 other tissues See more
Orthologs
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Genomic context

See Aqp1 in Genome Data Viewer
Location:
6 B3; 6 27.38 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (55313284..55325540)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (55336299..55348555)

Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene MINDY lysine 48 deubiquitinase 4 Neighboring gene predicted gene, 38819 Neighboring gene RIKEN cDNA 6430584L05 gene Neighboring gene growth hormone releasing hormone receptor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (7) 
  • Targeted (6)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Items 1 - 25 of 27
Function Evidence Code Pubs
enables ammonium channel activity  
enables ammonium channel activity  
enables ammonium channel activity  
enables carbon dioxide transmembrane transporter activity  
enables carbon dioxide transmembrane transporter activity  
enables carbon dioxide transmembrane transporter activity  
enables ephrin receptor binding PubMed 
enables glycerol transmembrane transporter activity  
enables glycerol transmembrane transporter activity  
enables glycerol transmembrane transporter activity  
enables hydrogen peroxide channel activity  
enables identical protein binding  
enables identical protein binding  
enables intracellularly cGMP-activated cation channel activity  
enables intracellularly cGMP-activated cation channel activity  
enables nitric oxide transmembrane transporter activity  
enables nitric oxide transmembrane transporter activity  
enables potassium channel activity  
enables potassium channel activity  
enables potassium ion transmembrane transporter activity PubMed 
enables transmembrane transporter activity  
enables water channel activity  
enables water channel activity  
enables water channel activity  
enables water channel activity PubMed 
enables water transmembrane transporter activity PubMed 
enables water transmembrane transporter activity  
Items 1 - 25 of 27
Items 1 - 25 of 97
Process Evidence Code Pubs
involved_in ammonium transmembrane transport  
involved_in ammonium transmembrane transport  
involved_in cGMP-mediated signaling  
involved_in cGMP-mediated signaling  
acts_upstream_of_or_within camera-type eye morphogenesis PubMed 
involved_in carbon dioxide transmembrane transport  
involved_in carbon dioxide transmembrane transport  
involved_in carbon dioxide transmembrane transport  
involved_in carbon dioxide transport  
involved_in carbon dioxide transport  
acts_upstream_of cell migration PubMed 
involved_in cell volume homeostasis  
involved_in cell volume homeostasis  
involved_in cellular homeostasis  
involved_in cellular homeostasis  
involved_in cellular hyperosmotic response  
involved_in cellular hyperosmotic response  
involved_in cellular response to UV  
involved_in cellular response to UV  
involved_in cellular response to cAMP  
involved_in cellular response to cAMP  
involved_in cellular response to copper ion  
involved_in cellular response to copper ion  
involved_in cellular response to dexamethasone stimulus  
involved_in cellular response to dexamethasone stimulus  
involved_in cellular response to hydrogen peroxide  
involved_in cellular response to hydrogen peroxide  
involved_in cellular response to hypoxia  
involved_in cellular response to hypoxia  
involved_in cellular response to mechanical stimulus  
involved_in cellular response to mechanical stimulus  
involved_in cellular response to mercury ion  
involved_in cellular response to mercury ion  
involved_in cellular response to nitric oxide  
involved_in cellular response to nitric oxide  
involved_in cellular response to retinoic acid  
involved_in cellular response to retinoic acid  
involved_in cellular response to salt stress  
involved_in cellular response to salt stress  
involved_in cerebrospinal fluid secretion  
acts_upstream_of_or_within corticotropin secretion PubMed 
involved_in defense response to Gram-negative bacterium PubMed 
involved_in defense response to Gram-negative bacterium  
acts_upstream_of_or_within establishment of localization in cell PubMed 
acts_upstream_of_or_within establishment of localization in cell PubMed 
involved_in establishment or maintenance of actin cytoskeleton polarity  
involved_in establishment or maintenance of actin cytoskeleton polarity  
acts_upstream_of fibroblast migration PubMed 
acts_upstream_of_or_within glomerular filtration PubMed 
involved_in glycerol transmembrane transport  
involved_in glycerol transmembrane transport  
involved_in hydrogen peroxide transmembrane transport  
involved_in hyperosmotic response  
involved_in intracellular water homeostasis  
involved_in intracellular water homeostasis  
involved_in lateral ventricle development PubMed 
acts_upstream_of_or_within lipid digestion PubMed 
involved_in metanephric descending thin limb development PubMed 
involved_in metanephric glomerulus vasculature development PubMed 
involved_in metanephric proximal convoluted tubule segment 2 development PubMed 
involved_in metanephric proximal straight tubule development PubMed 
acts_upstream_of_or_within multicellular organismal-level water homeostasis PubMed 
involved_in negative regulation of apoptotic process  
involved_in negative regulation of apoptotic process  
involved_in negative regulation of cysteine-type endopeptidase activity  
involved_in nitric oxide transport  
involved_in nitric oxide transport  
involved_in odontogenesis  
involved_in pancreatic juice secretion  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of angiogenesis  
involved_in positive regulation of epithelial cell migration  
involved_in positive regulation of epithelial cell migration  
acts_upstream_of_or_within positive regulation of fibroblast migration PubMed 
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of fibroblast proliferation  
involved_in positive regulation of lamellipodium assembly  
involved_in positive regulation of lamellipodium assembly  
involved_in positive regulation of saliva secretion  
involved_in positive regulation of saliva secretion  
involved_in potassium ion transmembrane transport  
involved_in potassium ion transport PubMed 
acts_upstream_of_or_within renal water absorption PubMed 
acts_upstream_of_or_within renal water absorption PubMed 
involved_in renal water transport  
involved_in renal water transport  
involved_in response to estrogen  
acts_upstream_of_or_within secretion by cell PubMed 
acts_upstream_of_or_within secretory granule organization PubMed 
acts_upstream_of_or_within sensory perception of pain PubMed 
involved_in transepithelial water transport  
involved_in transepithelial water transport  
acts_upstream_of_or_within water transport PubMed 
acts_upstream_of_or_within water transport PubMed 
acts_upstream_of_or_within water transport PubMed 
involved_in water transport  
acts_upstream_of_or_within wound healing PubMed 
Items 1 - 25 of 97
Items 1 - 20 of 35
Component Evidence Code Pubs
part_of ankyrin-1 complex  
part_of ankyrin-1 complex  
located_in apical part of cell  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in axon PubMed 
located_in axon terminus  
located_in axon terminus  
located_in basal plasma membrane PubMed 
located_in basal plasma membrane  
located_in basal plasma membrane  
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in brush border PubMed 
located_in brush border  
located_in brush border membrane  
located_in brush border membrane  
located_in caveola PubMed 
located_in cytoplasm  
located_in cytoplasm  
located_in dense core granule membrane  
located_in extracellular exosome PubMed 
located_in extracellular exosome  
located_in membrane PubMed 
located_in neuronal cell body membrane  
located_in neuronal cell body membrane  
located_in nuclear membrane  
located_in nuclear membrane  
located_in nucleus  
located_in nucleus  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane PubMed 
located_in sarcolemma  
located_in sarcolemma  
Items 1 - 20 of 35

General protein information

Preferred Names
aquaporin-1
Names
AQP-1
DER2
aquaporin-CHIP
delayed early response protein 2
growth factor-induced delayed early response protein
water channel protein for red blood cells and kidney proximal tubule
NP_031498.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007472.2NP_031498.1  aquaporin-1

    See identical proteins and their annotated locations for NP_031498.1

    Status: VALIDATED

    Source sequence(s)
    AK081886, BB850287
    Consensus CDS
    CCDS20164.1
    UniProtKB/Swiss-Prot
    Q02013, Q542P1, Q91VY8
    UniProtKB/TrEMBL
    Q3TLW5
    Related
    ENSMUSP00000004774.4, ENSMUST00000004774.4
    Conserved Domains (1) summary
    pfam00230
    Location:4227
    MIP; Major intrinsic protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000072.7 Reference GRCm39 C57BL/6J

    Range
    55313284..55325540
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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