U.S. flag

An official website of the United States government

Atp1a1 ATPase, Na+/K+ transporting, alpha 1 polypeptide [ Mus musculus (house mouse) ]

Gene ID: 11928, updated on 13-Jan-2025

Summary

Official Symbol
Atp1a1provided by MGI
Official Full Name
ATPase, Na+/K+ transporting, alpha 1 polypeptideprovided by MGI
Primary source
MGI:MGI:88105
See related
Ensembl:ENSMUSG00000033161 AllianceGenome:MGI:88105
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atpa-1
Summary
Enables P-type sodium:potassium-exchanging transporter activity; phosphatase activity; and transmembrane transporter binding activity. Involved in osmosensory signaling pathway and sodium ion homeostasis. Acts upstream of or within several processes, including negative regulation of glucocorticoid biosynthetic process; positive regulation of striated muscle contraction; and regulation of heart contraction. Located in several cellular components, including T-tubule; basolateral plasma membrane; and postsynaptic density. Is active in plasma membrane. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in kidney adult (RPKM 909.8), duodenum adult (RPKM 621.7) and 19 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Atp1a1 in Genome Data Viewer
Location:
3 F2.2; 3 44.3 cM
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (101483535..101512023, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (101576219..101604707, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:101306075-101306330 Neighboring gene STARR-seq mESC enhancer starr_08540 Neighboring gene predicted gene, 40109 Neighboring gene predicted gene, 33162 Neighboring gene STARR-seq mESC enhancer starr_08542 Neighboring gene STARR-positive B cell enhancer ABC_E10202 Neighboring gene STARR-positive B cell enhancer ABC_E9080 Neighboring gene predicted gene, 33215 Neighboring gene predicted gene, 33265

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (9) 
  • Gene trapped (1) 
  • Targeted (2)  1 citation

Interactions

General gene information

Clone Names

  • MGC38419

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding  
enables ATP binding  
enables ATP binding  
enables ATP hydrolysis activity  
enables P-type potassium transmembrane transporter activity PubMed 
enables P-type sodium:potassium-exchanging transporter activity  
enables P-type sodium:potassium-exchanging transporter activity PubMed 
enables P-type sodium:potassium-exchanging transporter activity PubMed 
enables P-type sodium:potassium-exchanging transporter activity  
enables ankyrin binding  
enables metal ion binding  
enables phosphatase activity PubMed 
enables phosphatidylinositol 3-kinase binding  
enables potassium ion binding  
enables protein binding PubMed 
enables protein domain specific binding  
enables protein heterodimerization activity  
enables protein kinase binding  
enables protein-folding chaperone binding  
enables protein-folding chaperone binding  
enables sodium ion binding  
enables steroid hormone binding  
enables steroid hormone binding  
enables transmembrane transporter binding PubMed 
Items 1 - 25 of 35
Process Evidence Code Pubs
involved_in cellular response to mechanical stimulus  
involved_in cellular response to steroid hormone stimulus  
involved_in cellular response to steroid hormone stimulus  
involved_in establishment or maintenance of transmembrane electrochemical gradient PubMed 
acts_upstream_of heart contraction PubMed 
involved_in intracellular potassium ion homeostasis  
involved_in intracellular potassium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in intracellular sodium ion homeostasis  
involved_in membrane hyperpolarization  
involved_in membrane repolarization  
involved_in membrane repolarization  
acts_upstream_of_or_within negative regulation of glucocorticoid biosynthetic process PubMed 
acts_upstream_of_or_within negative regulation of heart contraction PubMed 
involved_in osmosensory signaling pathway PubMed 
acts_upstream_of_or_within positive regulation of heart contraction PubMed 
acts_upstream_of_or_within positive regulation of striated muscle contraction PubMed 
involved_in potassium ion import across plasma membrane  
involved_in potassium ion import across plasma membrane  
involved_in potassium ion transport  
involved_in proton transmembrane transport  
involved_in proton transmembrane transport PubMed 
acts_upstream_of_or_within regulation of blood pressure PubMed 
involved_in regulation of cardiac muscle cell contraction  
involved_in regulation of sodium ion transport  
involved_in regulation of sodium ion transport  
acts_upstream_of_or_within regulation of the force of heart contraction PubMed 
NOT involved_in response to glycoside PubMed 
involved_in response to glycoside  
acts_upstream_of_or_within response to xenobiotic stimulus PubMed 
involved_in sodium ion export across plasma membrane  
involved_in sodium ion export across plasma membrane  
involved_in sodium ion homeostasis PubMed 
involved_in sodium ion transport  
involved_in transmembrane transport  
Items 1 - 25 of 35
Items 1 - 20 of 34
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in T-tubule PubMed 
located_in T-tubule  
located_in apical plasma membrane PubMed 
located_in apical plasma membrane  
located_in axon  
located_in basolateral plasma membrane PubMed 
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
located_in caveola  
located_in endoplasmic reticulum  
located_in endosome  
located_in intercalated disc  
located_in lateral plasma membrane  
located_in lateral plasma membrane  
located_in melanosome  
located_in membrane PubMed 
located_in membrane  
located_in membrane  
located_in myelin sheath PubMed 
located_in organelle membrane  
located_in organelle membrane  
is_active_in plasma membrane PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in postsynaptic density PubMed 
part_of protein-containing complex PubMed 
is_active_in sarcolemma  
located_in sarcolemma PubMed 
located_in sarcolemma  
part_of sodium:potassium-exchanging ATPase complex  
part_of sodium:potassium-exchanging ATPase complex  
located_in sperm flagellum  
located_in sperm flagellum  
Items 1 - 20 of 34

General protein information

Preferred Names
sodium/potassium-transporting ATPase subunit alpha-1
Names
Na(+)/K(+) ATPase alpha-1 subunit
sodium pump subunit alpha-1
NP_659149.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_144900.2NP_659149.1  sodium/potassium-transporting ATPase subunit alpha-1

    See identical proteins and their annotated locations for NP_659149.1

    Status: VALIDATED

    Source sequence(s)
    AC127357, AC131658, AK159306, BB863666, BE994800
    Consensus CDS
    CCDS17683.1
    UniProtKB/Swiss-Prot
    Q8VDN2, Q91Z09
    UniProtKB/TrEMBL
    Q3TXF9
    Related
    ENSMUSP00000039657.7, ENSMUST00000036493.8
    Conserved Domains (6) summary
    smart00831
    Location:40114
    Cation_ATPase_N; Cation transporter/ATPase, N-terminus
    COG4087
    Location:606732
    COG4087; Soluble P-type ATPase [General function prediction only]
    TIGR01106
    Location:291023
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit
    pfam00122
    Location:134365
    E1-E2_ATPase; E1-E2 ATPase
    pfam00689
    Location:7991008
    Cation_ATPase_C; Cation transporting ATPase, C-terminus
    pfam13246
    Location:427521
    Cation_ATPase; Cation transport ATPase (P-type)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    101483535..101512023 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.