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Atp5f1b ATP synthase F1 subunit beta [ Mus musculus (house mouse) ]

Gene ID: 11947, updated on 14-Jan-2025

Summary

Official Symbol
Atp5f1bprovided by MGI
Official Full Name
ATP synthase F1 subunit betaprovided by MGI
Primary source
MGI:MGI:107801
See related
Ensembl:ENSMUSG00000025393 AllianceGenome:MGI:107801
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Atp5b
Summary
Predicted to enable several functions, including adenyl ribonucleotide binding activity; angiostatin binding activity; and proton-transporting ATPase activity, rotational mechanism. Predicted to contribute to ATP hydrolysis activity and proton-transporting ATP synthase activity, rotational mechanism. Acts upstream of or within cellular response to interleukin-7; lipid metabolic process; and negative regulation of cell adhesion involved in substrate-bound cell migration. Located in mitochondrion. Is expressed in several structures, including central nervous system; eye; heart; hemolymphoid system; and integumental system. Orthologous to human ATP5F1B (ATP synthase F1 subunit beta). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Ubiquitous expression in heart adult (RPKM 1957.4), kidney adult (RPKM 1315.7) and 28 other tissues See more
Orthologs
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Genomic context

See Atp5f1b in Genome Data Viewer
Location:
10 D3; 10 76.39 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (127919176..127926257)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128083307..128090388)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_28254 Neighboring gene nascent polypeptide-associated complex alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E5198 Neighboring gene STARR-positive B cell enhancer ABC_E10658 Neighboring gene prostaglandin E synthase 3 Neighboring gene STARR-positive B cell enhancer ABC_E25 Neighboring gene predicted gene, 47438 Neighboring gene STARR-positive B cell enhancer ABC_E8377 Neighboring gene small nucleolar RNA, C/D box 59A Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127529132-127529333 Neighboring gene STARR-positive B cell enhancer ABC_E8993 Neighboring gene STARR-seq mESC enhancer starr_28259 Neighboring gene microRNA 677 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:127534859-127535012 Neighboring gene STARR-seq mESC enhancer starr_28261 Neighboring gene bromodomain adjacent to zinc finger domain, 2A Neighboring gene predicted gene, 51821 Neighboring gene RNA binding motif, single stranded interacting protein 2 Neighboring gene STARR-positive B cell enhancer ABC_E11466

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (3) 

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ADP binding  
enables ATP binding  
enables ATP binding  
enables ATP hydrolysis activity  
contributes_to ATP hydrolysis activity  
enables ATP hydrolysis activity  
enables MHC class I protein binding  
enables MHC class I protein binding  
enables angiostatin binding  
enables angiostatin binding  
enables calcium ion binding  
enables lipoprotein particle receptor activity  
enables protein binding PubMed 
contributes_to proton-transporting ATP synthase activity, rotational mechanism  
contributes_to proton-transporting ATP synthase activity, rotational mechanism  
enables proton-transporting ATP synthase activity, rotational mechanism  
enables proton-transporting ATP synthase activity, rotational mechanism  
enables proton-transporting ATPase activity, rotational mechanism  
enables proton-transporting ATPase activity, rotational mechanism  
Process Evidence Code Pubs
involved_in ATP biosynthetic process  
involved_in angiogenesis  
involved_in angiogenesis  
acts_upstream_of_or_within cellular response to interleukin-7 PubMed 
acts_upstream_of_or_within lipid metabolic process PubMed 
acts_upstream_of_or_within negative regulation of cell adhesion involved in substrate-bound cell migration PubMed 
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in positive regulation of blood vessel endothelial cell migration  
involved_in proton motive force-driven mitochondrial ATP synthesis  
involved_in proton motive force-driven mitochondrial ATP synthesis  
involved_in proton motive force-driven mitochondrial ATP synthesis  
involved_in proton transmembrane transport  
involved_in proton transmembrane transport  
involved_in receptor-mediated endocytosis  
involved_in regulation of intracellular pH  
involved_in regulation of intracellular pH  
Items 1 - 20 of 21
Component Evidence Code Pubs
located_in cell surface  
located_in cell surface  
located_in membrane  
located_in membrane raft  
located_in mitochondrial inner membrane PubMed 
located_in mitochondrial inner membrane  
located_in mitochondrial membrane  
located_in mitochondrial nucleoid  
located_in mitochondrial nucleoid  
located_in mitochondrion PubMed 
located_in mitochondrion PubMed 
located_in mitochondrion  
located_in myelin sheath PubMed 
located_in plasma membrane  
located_in plasma membrane  
part_of proton-transporting ATP synthase complex  
part_of proton-transporting ATP synthase complex  
part_of proton-transporting ATP synthase complex  
part_of proton-transporting ATP synthase complex, catalytic core F(1)  
part_of proton-transporting ATP synthase complex, catalytic core F(1)  
part_of proton-transporting ATP synthase complex, catalytic core F(1)  
Items 1 - 20 of 21

General protein information

Preferred Names
ATP synthase subunit beta, mitochondrial
Names
ATP synthase, H+ transporting mitochondrial F1 complex, alpha subunit
ATP synthase, H+ transporting mitochondrial F1 complex, beta subunit
mitochondrial ATP synthase, H+ transporting F1 complex beta subunit
NP_058054.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_016774.3NP_058054.2  ATP synthase subunit beta, mitochondrial precursor

    See identical proteins and their annotated locations for NP_058054.2

    Status: VALIDATED

    Source sequence(s)
    AC131120
    Consensus CDS
    CCDS24259.1
    UniProtKB/Swiss-Prot
    P56480, Q0QEP4, Q3TFD7, Q3TIP9, Q3TK44, Q3TWD5, Q3TX28, Q3U6U4, Q3U774, Q3UB69, Q3UF69, Q8CI65, Q8VEJ5, Q9CTI7, Q9CWX7
    Related
    ENSMUSP00000026459.6, ENSMUST00000026459.6
    Conserved Domains (1) summary
    PRK09280
    Location:58524
    PRK09280; F0F1 ATP synthase subunit beta; Validated

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    127919176..127926257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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