Avpr2 arginine vasopressin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Avpr2provided by MGI
Official Full Name: arginine vasopressin receptor 2provided by MGI
Primary source: MGI:MGI:88123
See related: Ensembl:ENSMUSG00000031390 AllianceGenome:MGI:88123
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: DI1; DIR; ND1; V2R; ADHR; VPV2R
Summary: This gene encodes a member of the G-protein coupled receptor 1 family and the vasopressin/oxytocin receptor subfamily. The encoded protein is an arginine vasopressin receptor which, when stimulated, activates the Gs protein/adenylyl cyclase signaling cascade and is involved in water and electrolyte homeostasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Expression: Biased expression in kidney adult (RPKM 17.2), thymus adult (RPKM 4.6) and 1 other tissue See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.46 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (72935371..72938034)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (73891765..73894428)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genome-Engineered mpkCCDc14 Cells as a New Resource for Studying AQP2.
Title: Genome-Engineered mpkCCDc14 Cells as a New Resource for Studying AQP2.
Vasopressin Receptor Type-2 Mediated Signaling in Renal Cell Carcinoma Stimulates Stromal Fibroblast Activation.
Title: Vasopressin Receptor Type-2 Mediated Signaling in Renal Cell Carcinoma Stimulates Stromal Fibroblast Activation.
Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes mellitus via a vasopressin receptor 2-dependent pathway.
Title: Upregulation of renal Na-K-2Cl cotransporter 2 in obese diabetes mellitus via a vasopressin receptor 2-dependent pathway.
Site-1 protease-derived (S1P-derived) soluble (pro)renin receptor (sPRR) participates in regulation of fluid homeostasis via targeting V2R. PF-429242 (S1P inhibitor) treatment or renal tubule-specific deletion of S1P impaired mice urine concentrating capability, which was rescued by sPRR-His. S1P-derived sPRR exerts a key role in determining renal V2R expression and, thus, urine concentrating capability.
Title: Site-1 protease-derived soluble (pro)renin receptor targets vasopressin receptor 2 to enhance urine concentrating capability.
type-2 vasopressin receptor in polycystic kidney disease is targeted by green mamba peptide
Title: Green mamba peptide targets type-2 vasopressin receptor against polycystic kidney disease.
Data show that upon heteromer formation with secretin receptor (SCTR), R137H, a nephrogenic diabetes insipidus (NDI)-causing vasopressin receptor 2 (AVPR2) mutant that is defective in trafficking to cell surface, can functionally be rescued.
Title: Signaling Modification by GPCR Heteromer and Its Implication on X-Linked Nephrogenic Diabetes Insipidus.
Conditional inactivation of Elf5 in the developing collecting ducts results in a small but significant reduction in the expression levels of Aqp2 and Avpr2 genes.
Title: Elf5 is a principal cell lineage specific transcription factor in the kidney that contributes to Aqp2 and Avpr2 gene expression.
Data show that cryptochrome Cry1 and Cry2 expression must be circadian and appropriately phased to support rhythms, and arginine vasopressin (AVP) receptor signaling is required to impose circuit-level circadian function.
Title: Rhythmic expression of cryptochrome induces the circadian clock of arrhythmic suprachiasmatic nuclei through arginine vasopressin signaling.
In polycystic kidney disease, structural or functional loss of cilia leads to abnormal trafficking of AQP2/V2R leading to enhanced salt and water absorption.
Title: Collecting duct cells that lack normal cilia have mislocalized vasopressin-2 receptors.
AVPR2 expression levels in the kidneys of male TALLYHO/JngJ mice, independent of diabetes disease state, were significantly reduced compared with those of B6 mice.
Title: Reduced aldehyde dehydrogenase activity and arginine vasopressin receptor 2 expression in the kidneys of male TALLYHO/JngJ mice of prediabetic age.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2) 1 citation

General gene information

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Clone Names

MGC124213, MGC124214, MGC124215, MGC129321

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables peptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables signaling receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables vasopressin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables vasopressin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to hormone stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of urine volume	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of intracellular signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of systemic arterial blood pressure	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vasoconstriction	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of systemic arterial blood pressure by vasopressin	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within response to cytokine	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in endosome	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: vasopressin V2 receptor

Names: antidiuretic hormone receptor; nephrogenic diabetes insipidus; renal-type arginine vasopressin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001276298.1 → NP_001263227.1 vasopressin V2 receptor isoform b

See identical proteins and their annotated locations for NP_001263227.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region which results in a frameshift, compared to variant 1. The encoded isoform (b) is shorter and has a distinct C-terminus, compared to isoform a.

Source sequence(s)

AL672002

Consensus CDS

CCDS72396.1

UniProtKB/TrEMBL

Q3SWS4

Related

ENSMUSP00000099011.3, ENSMUST00000101470.3

Conserved Domains (2) summary

pfam00001
Location:54 → 240

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:43 → 144

7tm_4; Olfactory receptor
NM_001276299.1 → NP_001263228.1 vasopressin V2 receptor isoform c

See identical proteins and their annotated locations for NP_001263228.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. It encodes a shorter protein (isoform c) compared to isoform a.

Source sequence(s)

AL672002, BC107005

Consensus CDS

CCDS72397.1

UniProtKB/TrEMBL

Q3KNZ4, Q684Q3

Related

ENSMUSP00000110037.2, ENSMUST00000114395.2

Conserved Domains (1) summary

pfam00001
Location:8 → 114

7tm_1; 7 transmembrane receptor (rhodopsin family)
NM_019404.2 → NP_062277.1 vasopressin V2 receptor isoform a

See identical proteins and their annotated locations for NP_062277.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a).

Source sequence(s)

AL672002, BC104729

Consensus CDS

CCDS30216.1

UniProtKB/Swiss-Prot

O88721

UniProtKB/TrEMBL

Q3SWS1

Related

ENSMUSP00000033765.8, ENSMUST00000033765.8

Conserved Domains (1) summary

cd15388
Location:38 → 326

7tmA_V2R; vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000086.8 Reference GRCm39 C57BL/6J

Range

72935371..72938034

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527756.4 → XP_006527819.1 vasopressin V2 receptor isoform X1

See identical proteins and their annotated locations for XP_006527819.1

UniProtKB/Swiss-Prot

O88721

UniProtKB/TrEMBL

Q3SWS1

Conserved Domains (1) summary

cd15388
Location:38 → 326

7tmA_V2R; vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors
XM_017318365.2 → XP_017173854.1 vasopressin V2 receptor isoform X2

Conserved Domains (1) summary

cd15388
Location:37 → 325

7tmA_V2R; vasopressin receptor 2, member of the class A family of seven-transmembrane G protein-coupled receptors