U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Bach1 BTB and CNC homology 1, basic leucine zipper transcription factor 1 [ Mus musculus (house mouse) ]

Gene ID: 12013, updated on 9-May-2024

Summary

Go to the top of the page Help
Official Symbol
Bach1provided by MGI
Official Full Name
BTB and CNC homology 1, basic leucine zipper transcription factor 1provided by MGI
Primary source
MGI:MGI:894680
See related
Ensembl:ENSMUSG00000025612 AllianceGenome:MGI:894680
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
6230421P05Rik
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription repressor activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II and positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Orthologous to human BACH1 (BTB domain and CNC homolog 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thymus adult (RPKM 12.9), large intestine adult (RPKM 9.3) and 27 other tissues See more
Orthologs
human all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
16 C3.3; 16 49.84 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (87495842..87530234)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (87698954..87733346)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41401 Neighboring gene predicted gene, 22808 Neighboring gene predicted gene, 53917 Neighboring gene STARR-seq mESC enhancer starr_41404 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87709451-87709604 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87723887-87724040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87727532-87727781 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:87729167-87729320 Neighboring gene predicted gene, 32925 Neighboring gene predicted gene, 23994 Neighboring gene RIKEN cDNA 2810407A14 gene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. BACH1 regulates erythrophagocytosis and iron-recycling in β-thalassemia. Penglong T, et al. Genes Cells, 2023 Mar. PMID 36565308
  2. Deletion of BACH1 Attenuates Atherosclerosis by Reducing Endothelial Inflammation. Jia M, et al. Circ Res, 2022 Apr. PMID 35196865
  3. Genetic BACH1 deficiency alters mitochondrial function and increases NLRP3 inflammasome activation in mouse macrophages. Pradhan P, et al. Redox Biol, 2022 May. PMID 35189551, Free PMC Article
  4. Bach1 plays an important role in angiogenesis through regulation of oxidative stress. Yusoff FM, et al. Microvasc Res, 2021 Mar. PMID 33373621
  5. BTB and CNC homology 1 inhibition ameliorates fibrosis and inflammation via blocking ERK pathway in pulmonary fibrosis. Liu Y, et al. Exp Lung Res, 2021 Feb-Mar. PMID 33238752

See all (123) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.
    Title: BACH1 changes microglial metabolism and affects astrogenesis during mouse brain development.
  2. BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.
    Title: BACH1 promotes tissue necrosis and Mycobacterium tuberculosis susceptibility.
  3. BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.
    Title: BACH1 controls hepatic insulin signaling and glucose homeostasis in mice.
  4. CircZfp609 contributes to cerebral infarction via sponging miR-145a-5p to regulate BACH1.
    Title: CircZfp609 contributes to cerebral infarction via sponging miR-145a-5p to regulate BACH1.
  5. BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
    Title: BACH1 encourages ferroptosis by activating KDM4C-mediated COX2 demethylation after cerebral ischemia-reperfusion injury.
  6. BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.
    Title: BACH1 deficiency prevents neointima formation and maintains the differentiated phenotype of vascular smooth muscle cells by regulating chromatin accessibility.
  7. Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway.
    Title: Thioredoxin facilitates hepatocellular carcinoma stemness and metastasis by increasing BACH1 stability to activate the AKT/mTOR pathway.
  8. BACH1 regulates erythrophagocytosis and iron-recycling in beta-thalassemia.
    Title: BACH1 regulates erythrophagocytosis and iron-recycling in β-thalassemia.
  9. BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.
    Title: BACH1-induced ferroptosis drives lymphatic metastasis by repressing the biosynthesis of monounsaturated fatty acids.
  10. ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling.
    Title: ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling.
Submit: New GeneRIF Correction See all GeneRIFs (77)

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (4)  1 citation

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables ligand-activated transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA repair ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of RNA polymerase II transcription regulator complex ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

Go to the top of the page Help
Preferred Names
transcription regulator protein BACH1
Names
BTB and CNC homolog 1
BTB and CNC homology 1 transcription factor

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007520.2 → NP_031546.1  transcription regulator protein BACH1

    See identical proteins and their annotated locations for NP_031546.1

    Status: VALIDATED

    Source sequence(s)
    AC164108, AK140903, AK141405
    Consensus CDS
    CCDS28293.1
    UniProtKB/Swiss-Prot
    P97302
    UniProtKB/TrEMBL
    Q3URL4, Q3US24
    Related
    ENSMUSP00000026703.6, ENSMUST00000026703.6
    Conserved Domains (2) summary
    cd14719
    Location:554 → 624
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18277
    Location:7 → 126
    BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    87495842..87530234
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030248939.1 → XP_030104799.1  transcription regulator protein BACH1 isoform X2

    Conserved Domains (1) summary
    cd14719
    Location:272 → 342
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain

  2. XM_006522879.4 → XP_006522942.1  transcription regulator protein BACH1 isoform X1

    See identical proteins and their annotated locations for XP_006522942.1

    UniProtKB/Swiss-Prot
    P97302
    UniProtKB/TrEMBL
    Q3URL4, Q3US24
    Conserved Domains (2) summary
    cd14719
    Location:554 → 624
    bZIP_BACH; Basic leucine zipper (bZIP) domain of BTB and CNC homolog (BACH) proteins: a DNA-binding and dimerization domain
    cd18277
    Location:7 → 126
    BTB_POZ_BACH1; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog 1 (BACH1)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P97302.1 GenPept UniProtKB/Swiss-Prot:P97302

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous