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Bcl7c B cell CLL/lymphoma 7C [ Mus musculus (house mouse) ]

Gene ID: 12055, updated on 30-Apr-2024

Summary

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Official Symbol
Bcl7cprovided by MGI
Official Full Name
B cell CLL/lymphoma 7Cprovided by MGI
Primary source
MGI:MGI:1332237
See related
Ensembl:ENSMUSG00000030814 AllianceGenome:MGI:1332237
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C230096E12Rik
Summary
Predicted to act upstream of or within apoptotic process. Is expressed in embryo. Orthologous to human BCL7C (BAF chromatin remodeling complex subunit BCL7C). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in whole brain E14.5 (RPKM 8.6), CNS E18 (RPKM 7.8) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Bcl7c in Genome Data Viewer
Location:
7 F3; 7 69.65 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (127260626..127307938, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (127661454..127708766, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 51458 Neighboring gene predicted gene, 53373 Neighboring gene predicted gene, 39090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:134851639-134851826 Neighboring gene microRNA 762 Neighboring gene cardiotrophin 1 Neighboring gene cardiotrophin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. RNA interference of IL-10 in leukemic B-1 cells. McCarthy BA, et al. Cancer Immun, 2004 Jul 23. PMID 15270555
  2. The SWI/SNF subunit Bcl7a contributes to motor coordination and Purkinje cell function. Wischhof L, et al. Sci Rep, 2017 Dec 6. PMID 29213114, Free PMC Article
  3. The BCL7 gene family: deletion of BCL7B in Williams syndrome. Jadayel DM, et al. Gene, 1998 Dec 11. PMID 9931421
  4. Proteomic and bioinformatic analysis of mammalian SWI/SNF complexes identifies extensive roles in human malignancy. Kadoch C, et al. Nat Genet, 2013 Jun. PMID 23644491, Free PMC Article
  5. BCL7A-containing SWI/SNF/BAF complexes modulate mitochondrial bioenergetics during neural progenitor differentiation. Wischhof L, et al. EMBO J, 2022 Dec 1. PMID 36305367, Free PMC Article

See all (33) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chromatin remodeling NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of cell differentiation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of cell population proliferation NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of double-strand break repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G0 to G1 transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of G1/S transition of mitotic cell cycle NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of mitotic metaphase/anaphase transition NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of nucleotide-excision repair NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of GBAF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of SWI/SNF complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of SWI/SNF complex ISO
Inferred from Sequence Orthology
more info
  
part_of SWI/SNF complex NAS
Non-traceable Author Statement
more info
 PubMed 
part_of chromatin NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
B-cell CLL/lymphoma 7 protein family member C
Names
B-cell chronic lymphocytic leukemia/lymphoma 7C protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001347652.1 → NP_001334581.1  B-cell CLL/lymphoma 7 protein family member C isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC124507
    Consensus CDS
    CCDS85422.1
    UniProtKB/TrEMBL
    A0A0U1RNX8
    Related
    ENSMUSP00000145743.2, ENSMUST00000205977.2

  2. NM_009746.2 → NP_033876.1  B-cell CLL/lymphoma 7 protein family member C isoform 2

    See identical proteins and their annotated locations for NP_033876.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    BC005673
    Consensus CDS
    CCDS21874.1
    UniProtKB/Swiss-Prot
    O08664, Q99LS2
    Related
    ENSMUSP00000057937.9, ENSMUST00000061468.9
    Conserved Domains (2) summary
    PHA03249
    Location:93 → 177
    PHA03249; DNA packaging tegument protein UL25; Provisional
    pfam04714
    Location:4 → 50
    BCL_N; BCL7, N-terminal conserver region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    127260626..127307938 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O08664.1 GenPept UniProtKB/Swiss-Prot:O08664

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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