U.S. flag

An official website of the United States government

Bmp6 bone morphogenetic protein 6 [ Mus musculus (house mouse) ]

Gene ID: 12161, updated on 4-Jan-2025

Summary

Official Symbol
Bmp6provided by MGI
Official Full Name
bone morphogenetic protein 6provided by MGI
Primary source
MGI:MGI:88182
See related
Ensembl:ENSMUSG00000039004 AllianceGenome:MGI:88182
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Vgr1; D13Wsu115e
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates a wide range of biological processes including iron homeostasis, fat and bone development, and ovulation. Mice lacking this gene exhibit delayed ossification of the sternum, iron overload, and reduced fertility in females. [provided by RefSeq, Jul 2016]
Expression
Biased expression in lung adult (RPKM 52.0), kidney adult (RPKM 13.2) and 10 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Bmp6 in Genome Data Viewer
Location:
13 A3.3; 13 18.15 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (38529098..38684283)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (38345716..38500314)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 47978 Neighboring gene predicted gene, 47990 Neighboring gene RIKEN cDNA 4930579J19 gene Neighboring gene STARR-seq mESC enhancer starr_34248 Neighboring gene thioredoxin domain containing 5 Neighboring gene predicted gene, 31834 Neighboring gene predicted gene, 40922

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 
  • Targeted (4)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP receptor binding PubMed 
enables cytokine activity  
enables cytokine activity  
enables growth factor activity  
enables growth factor activity  
enables protein binding PubMed 
enables protein heterodimerization activity PubMed 
Items 1 - 25 of 59
Process Evidence Code Pubs
involved_in BMP signaling pathway  
acts_upstream_of_or_within BMP signaling pathway PubMed 
involved_in BMP signaling pathway  
involved_in bone development  
involved_in cartilage development  
involved_in cellular response to BMP stimulus  
involved_in cellular response to iron ion PubMed 
involved_in cellular response to mechanical stimulus  
acts_upstream_of_or_within endochondral ossification PubMed 
involved_in eye development PubMed 
involved_in immune response  
involved_in immune response  
involved_in inflammatory response PubMed 
acts_upstream_of_or_within intracellular iron ion homeostasis PubMed 
involved_in intracellular iron ion homeostasis PubMed 
involved_in kidney development PubMed 
acts_upstream_of_or_within male genitalia development PubMed 
involved_in multicellular organismal-level iron ion homeostasis PubMed 
involved_in multicellular organismal-level iron ion homeostasis  
involved_in multicellular organismal-level iron ion homeostasis  
involved_in negative regulation of adherens junction organization  
involved_in negative regulation of adherens junction organization  
involved_in negative regulation of cell-cell adhesion mediated by cadherin  
involved_in negative regulation of cell-cell adhesion mediated by cadherin  
involved_in negative regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within neuron differentiation PubMed 
involved_in ossification  
acts_upstream_of_or_within osteoblast differentiation PubMed 
involved_in positive regulation of SMAD protein signal transduction PubMed 
involved_in positive regulation of SMAD protein signal transduction  
involved_in positive regulation of aldosterone biosynthetic process  
involved_in positive regulation of aldosterone biosynthetic process  
involved_in positive regulation of aldosterone secretion  
involved_in positive regulation of aldosterone secretion  
involved_in positive regulation of bone mineralization  
involved_in positive regulation of bone mineralization  
involved_in positive regulation of chondrocyte differentiation  
involved_in positive regulation of chondrocyte differentiation  
involved_in positive regulation of endothelial cell differentiation PubMed 
involved_in positive regulation of endothelial cell proliferation PubMed 
involved_in positive regulation of epithelial cell proliferation  
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of lipopolysaccharide-mediated signaling pathway PubMed 
acts_upstream_of_or_within positive regulation of neuron differentiation PubMed 
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of peptidyl-tyrosine phosphorylation  
involved_in positive regulation of transcription by RNA polymerase II PubMed 
involved_in positive regulation of transcription by RNA polymerase II  
involved_in positive regulation of vascular permeability  
involved_in positive regulation of vascular permeability  
involved_in response to activity  
involved_in response to glucocorticoid  
involved_in response to magnesium ion  
involved_in response to retinoic acid  
involved_in type B pancreatic cell development  
involved_in type B pancreatic cell development  
Items 1 - 25 of 59
Component Evidence Code Pubs
located_in extracellular space PubMed 
is_active_in extracellular space  
located_in extracellular space  
located_in extracellular space  
located_in vesicle  
located_in vesicle  

General protein information

Preferred Names
bone morphogenetic protein 6
Names
VG-1-related protein

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007556.4NP_031582.1  bone morphogenetic protein 6 preproprotein

    See identical proteins and their annotated locations for NP_031582.1

    Status: VALIDATED

    Source sequence(s)
    AC124549, AC154747
    Consensus CDS
    CCDS26462.1
    UniProtKB/Swiss-Prot
    B2RRV6, P20722
    UniProtKB/TrEMBL
    Q3UXB2
    Related
    ENSMUSP00000126999.2, ENSMUST00000171970.3
    Conserved Domains (2) summary
    smart00204
    Location:409510
    TGFB; Transforming growth factor-beta (TGF-beta) family
    pfam00688
    Location:58359
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    38529098..38684283
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
External link. Please review our privacy policy.