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Bmp7 bone morphogenetic protein 7 [ Mus musculus (house mouse) ]

Gene ID: 12162, updated on 13-Jan-2025

Summary

Official Symbol
Bmp7provided by MGI
Official Full Name
bone morphogenetic protein 7provided by MGI
Primary source
MGI:MGI:103302
See related
Ensembl:ENSMUSG00000008999 AllianceGenome:MGI:103302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
OP1
Summary
This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. Mutation of this gene results in skeletal, kidney, and other developmental defects. [provided by RefSeq, Jul 2016]
Expression
Broad expression in adrenal adult (RPKM 31.1), kidney adult (RPKM 17.3) and 20 other tissues See more
Orthologs
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Genomic context

See Bmp7 in Genome Data Viewer
Location:
2 H3; 2 95.54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (172709805..172782114, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (172868012..172940321, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 36156 Neighboring gene RIKEN cDNA 1700055K11 gene Neighboring gene VISTA enhancer mm75 Neighboring gene STARR-seq mESC enhancer starr_06603 Neighboring gene STARR-seq mESC enhancer starr_06604 Neighboring gene predicted gene, 36254 Neighboring gene enhancer in intron 1 of Bmp7 Neighboring gene predicted gene, 40010 Neighboring gene STARR-positive B cell enhancer ABC_E4526 Neighboring gene predicted gene, 52538 Neighboring gene STARR-positive B cell enhancer ABC_E6029 Neighboring gene STARR-seq mESC enhancer starr_06607 Neighboring gene SPO11 initiator of meiotic double stranded breaks Neighboring gene ribonucleic acid export 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP receptor binding PubMed 
enables cytokine activity  
enables cytokine activity PubMed 
enables growth factor activity  
enables heparin binding  
enables heparin binding  
enables protein binding PubMed 
Items 1 - 25 of 95
Process Evidence Code Pubs
involved_in BMP signaling pathway  
acts_upstream_of_or_within BMP signaling pathway PubMed 
involved_in BMP signaling pathway  
involved_in allantois development PubMed 
acts_upstream_of ameloblast differentiation PubMed 
acts_upstream_of_or_within anatomical structure formation involved in morphogenesis PubMed 
acts_upstream_of_or_within animal organ morphogenesis PubMed 
acts_upstream_of_or_within axon guidance PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within branching morphogenesis of an epithelial tube PubMed 
acts_upstream_of_or_within camera-type eye morphogenesis PubMed 
involved_in cardiac muscle tissue development PubMed 
involved_in cardiac septum morphogenesis PubMed 
involved_in cartilage development  
acts_upstream_of_or_within cell development PubMed 
acts_upstream_of cell population proliferation PubMed 
involved_in cellular response to BMP stimulus  
involved_in chorio-allantoic fusion PubMed 
acts_upstream_of_or_within embryonic camera-type eye morphogenesis PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis PubMed 
acts_upstream_of_or_within embryonic pattern specification PubMed 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis PubMed 
acts_upstream_of_or_within embryonic skeletal joint morphogenesis PubMed 
involved_in endocardial cushion formation PubMed 
acts_upstream_of_or_within epithelial cell differentiation PubMed 
involved_in eye development PubMed 
involved_in heart trabecula morphogenesis PubMed 
involved_in hindbrain development PubMed 
acts_upstream_of_or_within kidney development PubMed 
involved_in kidney development PubMed 
acts_upstream_of mesenchymal cell apoptotic process involved in nephron morphogenesis PubMed 
involved_in mesenchymal cell differentiation  
involved_in mesenchymal cell differentiation  
involved_in mesenchyme development PubMed 
acts_upstream_of_or_within mesoderm formation PubMed 
involved_in metanephric mesenchymal cell proliferation involved in metanephros development PubMed 
involved_in metanephric mesenchyme morphogenesis PubMed 
involved_in monocyte aggregation  
involved_in monocyte aggregation  
involved_in negative regulation of DNA-templated transcription  
involved_in negative regulation of DNA-templated transcription  
acts_upstream_of_or_within negative regulation of Notch signaling pathway PubMed 
involved_in negative regulation of cell cycle  
acts_upstream_of_or_within negative regulation of cell population proliferation PubMed 
involved_in negative regulation of glomerular mesangial cell proliferation  
involved_in negative regulation of glomerular mesangial cell proliferation  
acts_upstream_of_or_within negative regulation of mesenchymal cell apoptotic process involved in nephron morphogenesis PubMed 
involved_in negative regulation of mitotic nuclear division  
involved_in negative regulation of mitotic nuclear division  
acts_upstream_of_or_within negative regulation of neurogenesis PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
acts_upstream_of_or_within negative regulation of neuron differentiation PubMed 
acts_upstream_of_or_within negative regulation of prostatic bud formation PubMed 
involved_in nephrogenic mesenchyme morphogenesis PubMed 
involved_in neural fold elevation formation PubMed 
acts_upstream_of_or_within neuron projection morphogenesis PubMed 
acts_upstream_of_or_within neuron projection morphogenesis PubMed 
acts_upstream_of_or_within odontogenesis of dentin-containing tooth PubMed 
involved_in ossification  
acts_upstream_of_or_within pattern specification process PubMed 
involved_in pericardium morphogenesis PubMed 
involved_in pharyngeal system development PubMed 
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of DNA-templated transcription  
involved_in positive regulation of SMAD protein signal transduction  
involved_in positive regulation of SMAD protein signal transduction  
acts_upstream_of_or_within positive regulation of apoptotic process PubMed 
involved_in positive regulation of bone mineralization  
involved_in positive regulation of bone mineralization  
involved_in positive regulation of brown fat cell differentiation  
involved_in positive regulation of brown fat cell differentiation  
involved_in positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis PubMed 
involved_in positive regulation of dendrite development  
involved_in positive regulation of dendrite development  
acts_upstream_of_or_within positive regulation of epithelial cell differentiation PubMed 
involved_in positive regulation of epithelial to mesenchymal transition PubMed 
involved_in positive regulation of gene expression  
involved_in positive regulation of gene expression  
involved_in positive regulation of heterotypic cell-cell adhesion  
involved_in positive regulation of heterotypic cell-cell adhesion  
involved_in positive regulation of hyaluranon cable assembly  
involved_in positive regulation of hyaluranon cable assembly  
acts_upstream_of_or_within positive regulation of neuron differentiation PubMed 
involved_in positive regulation of osteoblast differentiation  
involved_in positive regulation of osteoblast differentiation  
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II PubMed 
acts_upstream_of_or_within regulation of branching involved in prostate gland morphogenesis PubMed 
involved_in regulation of phosphorylation  
involved_in response to estradiol  
involved_in response to peptide hormone  
involved_in response to vitamin D  
acts_upstream_of_or_within salivary gland morphogenesis PubMed 
acts_upstream_of_or_within tube morphogenesis PubMed 
involved_in ureteric bud development PubMed 
Items 1 - 25 of 95
Component Evidence Code Pubs
located_in collagen-containing extracellular matrix  
located_in collagen-containing extracellular matrix  
is_active_in extracellular space  
located_in extracellular space PubMed 
located_in extracellular space  
located_in vesicle  
located_in vesicle  

General protein information

Preferred Names
bone morphogenetic protein 7
Names
osteogenic protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_007557.3NP_031583.2  bone morphogenetic protein 7 preproprotein

    See identical proteins and their annotated locations for NP_031583.2

    Status: REVIEWED

    Source sequence(s)
    AL929140, CA316109, CA451657, CF540870, CJ094104, CJ164635
    Consensus CDS
    CCDS17136.1
    UniProtKB/Swiss-Prot
    P23359, Q91XF7
    Related
    ENSMUSP00000009143.8, ENSMUST00000009143.8
    Conserved Domains (2) summary
    cd19397
    Location:324430
    TGF_beta_BMP7; transforming growth factor beta (TGF-beta) like domain found in bone morphogenetic protein 7 (BMP-7) and similar proteins
    pfam00688
    Location:35279
    TGFb_propeptide; TGF-beta propeptide

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    172709805..172782114 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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