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Calca calcitonin/calcitonin-related polypeptide, alpha [ Mus musculus (house mouse) ]

Gene ID: 12310, updated on 14-Jan-2025

Summary

Official Symbol
Calcaprovided by MGI
Official Full Name
calcitonin/calcitonin-related polypeptide, alphaprovided by MGI
Primary source
MGI:MGI:2151253
See related
Ensembl:ENSMUSG00000030669 AllianceGenome:MGI:2151253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CA; Ct; Ctn; Calc; Cgrp; CGRP1; Calc1; CGRP-1
Summary
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide (CGRP) and katacalcin. Alternative splicing of the mRNA results in multiple variants that encode either calcitonin or CGRP preproproteins. Post-translational processing of the calcitonin and CGRP propeptides results in either calcitonin and katacalcin, or CGRP, respectively. Calcitonin and katacalcin modulate calcium levels in the blood stream. CGRP can function as a vasodilator and play a role in the transmission of pain. The human homolog of CGRP was found to have antimicrobial activity. [provided by RefSeq, Mar 2015]
Expression
Biased expression in CNS E11.5 (RPKM 1.9), cerebellum adult (RPKM 1.7) and 13 other tissues See more
Orthologs
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Genomic context

See Calca in Genome Data Viewer
Location:
7 F1; 7 59.99 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (114225223..114236145, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (114625981..114636910, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933406I18 gene Neighboring gene STARR-positive B cell enhancer mm9_chr7:121575722-121576022 Neighboring gene STARR-positive B cell enhancer ABC_E8203 Neighboring gene phosphodiesterase 3B, cGMP-inhibited Neighboring gene STARR-positive B cell enhancer mm9_chr7:121623448-121623749 Neighboring gene STARR-positive B cell enhancer ABC_E9702 Neighboring gene STARR-seq mESC enhancer starr_19929 Neighboring gene STARR-seq mESC enhancer starr_19930 Neighboring gene cytochrome P450, family 2, subfamily r, polypeptide 1 Neighboring gene STARR-seq mESC enhancer starr_19932 Neighboring gene STARR-seq mESC enhancer starr_19933 Neighboring gene Rho GTPase activating protein 21 pseudogene Neighboring gene ribosomal protein L5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (10) 
  • Targeted (11)  1 citation

Pathways from PubChem

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables calcitonin receptor binding  
enables calcitonin receptor binding PubMed 
enables calcitonin receptor binding  
enables identical protein binding  
enables protein-containing complex binding  
enables signaling receptor binding PubMed 
enables signaling receptor binding  
enables signaling receptor binding PubMed 
Items 1 - 25 of 27
Process Evidence Code Pubs
acts_upstream_of_or_within activation of adenylate cyclase activity PubMed 
acts_upstream_of_or_within activation of adenylate cyclase activity PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway  
acts_upstream_of_or_within adenylate cyclase-activating G protein-coupled receptor signaling pathway PubMed 
acts_upstream_of_or_within artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure PubMed 
acts_upstream_of cell adhesion  
acts_upstream_of_or_within cellular response to nerve growth factor stimulus PubMed 
acts_upstream_of_or_within detection of temperature stimulus involved in sensory perception of pain PubMed 
acts_upstream_of_or_within feeding behavior PubMed 
acts_upstream_of_or_within inflammatory response PubMed 
acts_upstream_of_or_within intracellular calcium ion homeostasis PubMed 
acts_upstream_of_or_within negative regulation of blood pressure PubMed 
acts_upstream_of_or_within negative regulation of blood pressure PubMed 
involved_in negative regulation of blood pressure  
acts_upstream_of_or_within negative regulation of ossification PubMed 
acts_upstream_of_or_within negative regulation of smooth muscle contraction PubMed 
involved_in negative regulation of smooth muscle contraction  
acts_upstream_of_or_within nervous system process involved in regulation of systemic arterial blood pressure PubMed 
acts_upstream_of_or_within neuropeptide signaling pathway PubMed 
acts_upstream_of ossification PubMed 
acts_upstream_of_or_within positive regulation of cell adhesion  
involved_in regulation of cytosolic calcium ion concentration  
acts_upstream_of_or_within response to heat PubMed 
acts_upstream_of_or_within response to pain PubMed 
acts_upstream_of smooth muscle contraction PubMed 
acts_upstream_of_or_within sperm capacitation PubMed 
involved_in vasodilation  
Items 1 - 25 of 27
Component Evidence Code Pubs
located_in axon PubMed 
located_in axon  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in extracellular region PubMed 
located_in extracellular region PubMed 
is_active_in extracellular space  
located_in extracellular space PubMed 
is_active_in hippocampal mossy fiber to CA3 synapse  
located_in intracellular anatomical structure PubMed 
located_in neuron projection PubMed 
located_in neuronal cell body  
is_active_in neuronal dense core vesicle  
located_in terminal bouton PubMed 

General protein information

Preferred Names
calcitonin gene-related peptide 1
Names
alpha-type CGRP
calcitonin gene-related peptide I

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001033954.3NP_001029126.1  calcitonin gene-related peptide 1 isoform Cgrp preproprotein

    See identical proteins and their annotated locations for NP_001029126.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks the 3' terminal exon and has two alternate 3' exons, compared to variant 1. The resulting isoform (Cgrp) is shorter and has a distinct C-terminus, compared to isoform Calca. Both variants 2 and 3 encode the same isoform Cgrp.
    Source sequence(s)
    BB749493, BC028771, BU842988, CJ060164
    Consensus CDS
    CCDS21762.1
    UniProtKB/Swiss-Prot
    Q99JA0
    Related
    ENSMUSP00000032906.5, ENSMUST00000032906.11
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  2. NM_001289444.1NP_001276373.1  calcitonin gene-related peptide 1 isoform Cgrp preproprotein

    See identical proteins and their annotated locations for NP_001276373.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) has an altenate splice site in the 5' UTR, lacks the 3' terminal exon and has two alternate 3' exons, compared to variant 1. The resulting isoform (Cgrp) is shorter and has a distinct C-terminus, compared to isoform Calca. Both variants 2 and 3 encode the same isoform Cgrp.
    Source sequence(s)
    AF330212, BB749493, BC028771, BU842988, CJ057527, CJ060164
    Consensus CDS
    CCDS21762.1
    UniProtKB/Swiss-Prot
    Q99JA0
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  3. NM_001305616.1NP_001292545.1  calcitonin gene-related peptide 1 isoform Calca preproprotein

    See identical proteins and their annotated locations for NP_001292545.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Both variants 1 and 4 encode the same isoform Calca.
    Source sequence(s)
    AC156617, AK132582, BC030071, CJ060164
    Consensus CDS
    CCDS21763.1
    UniProtKB/Swiss-Prot
    P70160, Q8K1K5
    UniProtKB/TrEMBL
    Q3V1A7
    Related
    ENSMUSP00000146328.2, ENSMUST00000206853.2
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  4. NM_007587.2NP_031613.2  calcitonin gene-related peptide 1 isoform Calca preproprotein

    See identical proteins and their annotated locations for NP_031613.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (Calca). Both variants 1 and 4 encode the same protein.
    Source sequence(s)
    BC030071, CJ060164, X97991
    Consensus CDS
    CCDS21763.1
    UniProtKB/Swiss-Prot
    P70160, Q8K1K5
    UniProtKB/TrEMBL
    Q3V1A7
    Related
    ENSMUSP00000032907.8, ENSMUST00000032907.9
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    114225223..114236145 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011241660.4XP_011239962.1  calcitonin gene-related peptide 1 isoform X2

    See identical proteins and their annotated locations for XP_011239962.1

    UniProtKB/Swiss-Prot
    Q99JA0
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  2. XM_030242032.1XP_030097892.1  calcitonin gene-related peptide 1 isoform X2

    UniProtKB/Swiss-Prot
    Q99JA0
    Conserved Domains (1) summary
    pfam00214
    Location:1124
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
  3. XM_030242031.1XP_030097891.1  calcitonin gene-related peptide 1 isoform X1

    UniProtKB/Swiss-Prot
    P70160, Q8K1K5
    UniProtKB/TrEMBL
    Q3V1A7
    Conserved Domains (1) summary
    pfam00214
    Location:1121
    Calc_CGRP_IAPP; Calcitonin / CGRP / IAPP family
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