Pacsin2 protein kinase C and casein kinase substrate in neurons 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pacsin2provided by RGD
Official Full Name: protein kinase C and casein kinase substrate in neurons 2provided by RGD
Primary source: RGD:69411
See related: Ensembl:ENSRNOG00000009756 AllianceGenome:RGD:69411
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: SdpII
Summary: Predicted to enable cytoskeletal protein binding activity; identical protein binding activity; and phosphatidic acid binding activity. Predicted to be involved in several processes, including caveolin-mediated endocytosis; plasma membrane organization; and protein localization to endosome. Predicted to act upstream of or within negative regulation of endocytosis. Predicted to be located in several cellular components, including caveola; nuclear speck; and recycling endosome membrane. Predicted to be extrinsic component of membrane. Predicted to be active in endosome; glutamatergic synapse; and plasma membrane. Orthologous to human PACSIN2 (protein kinase C and casein kinase substrate in neurons 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 141.9), Kidney (RPKM 114.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q34

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (116385571..116478609, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (114505525..114599087, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (124224210..124317407, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phosphorylation of PACSIN2 at S313 Regulates Podocyte Architecture in Coordination with N-WASP.
Title: Phosphorylation of PACSIN2 at S313 Regulates Podocyte Architecture in Coordination with N-WASP.
in addition to a crucial role in endocytic internalization, syndapin protein complexes play an important role in endocytic receptor recycling
Title: EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.
EHD1 may regulate/participate in the functional pathways of both GS32 and syndapin II in a mutual exclusive manner
Title: Mutually exclusive interactions of EHD1 with GS32 and syndapin II.
Syndapins may coordinate N-WASP and dynamin functions during receptor-mediated endocytosis. Local actin polymerization induced by syndapin-N-WASP interactions may support clathrin-coated vesicle detachment and movement away from the plasma membrane.
Title: Syndapins integrate N-WASP in receptor-mediated endocytosis.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH141067 (e-PCR)
- UniSTS:223067

d7rat128 (e-PCR)
- UniSTS:122315

RH127347 (e-PCR)
- UniSTS:210657

RH140830 (e-PCR)
- UniSTS:210657

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytoskeletal protein binding	IEA Inferred from Electronic Annotation more info
enables cytoskeletal protein binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lipid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	IEA Inferred from Electronic Annotation more info
enables phosphatidic acid binding	ISO Inferred from Sequence Orthology more info
enables phosphatidic acid binding	ISS Inferred from Sequence or Structural Similarity more info
enables phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in actin cytoskeleton organization	IEA Inferred from Electronic Annotation more info
involved_in caveola assembly	IEA Inferred from Electronic Annotation more info
involved_in caveola assembly	ISO Inferred from Sequence Orthology more info
involved_in caveola assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in caveolin-mediated endocytosis	IEA Inferred from Electronic Annotation more info
involved_in caveolin-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in caveolin-mediated endocytosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell projection morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in cell projection morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in cell projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in modulation of chemical synaptic transmission	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endocytosis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of endocytosis	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane tubulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in plasma membrane tubulation	IEA Inferred from Electronic Annotation more info
involved_in plasma membrane tubulation	ISO Inferred from Sequence Orthology more info
involved_in plasma membrane tubulation	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to endosome	IEA Inferred from Electronic Annotation more info
involved_in protein localization to endosome	ISO Inferred from Sequence Orthology more info
involved_in regulation of endocytosis	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in caveola	IEA Inferred from Electronic Annotation more info
located_in caveola	ISO Inferred from Sequence Orthology more info
located_in cell-cell junction	IEA Inferred from Electronic Annotation more info
located_in cell-cell junction	ISO Inferred from Sequence Orthology more info
located_in centriolar satellite	IEA Inferred from Electronic Annotation more info
located_in centriolar satellite	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in recycling endosome membrane	IEA Inferred from Electronic Annotation more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info
located_in ruffle membrane	IEA Inferred from Electronic Annotation more info
NOT located_in trans-Golgi network	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein kinase C and casein kinase substrate in neurons 2 protein

Names: SdpIIsyndapin II; synaptic dynamin-associated protein II; syndapin-2; syndapin-II

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_130740.2 → NP_570096.2 protein kinase C and casein kinase substrate in neurons 2 protein

See identical proteins and their annotated locations for NP_570096.2

Status: PROVISIONAL

Source sequence(s)

BC070911

UniProtKB/Swiss-Prot

Q9QY17, Q9QY18, Q9QY19, Q9QY20

UniProtKB/TrEMBL

Q6IRI3

Related

ENSRNOP00000072822.1, ENSRNOT00000088125.2

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:429 → 484

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

116385571..116478609 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006242055.4 → XP_006242117.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

See identical proteins and their annotated locations for XP_006242117.1

UniProtKB/Swiss-Prot

Q9QY17, Q9QY18, Q9QY19, Q9QY20

UniProtKB/TrEMBL

Q6IRI3

Related

ENSRNOP00000013428.6

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:429 → 484

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_063262926.1 → XP_063118996.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X7
XM_063262920.1 → XP_063118990.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X5
XM_063262921.1 → XP_063118991.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X6

UniProtKB/TrEMBL

A6HT91
XM_039078308.2 → XP_038934236.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

UniProtKB/Swiss-Prot

Q9QY17, Q9QY18, Q9QY19, Q9QY20

UniProtKB/TrEMBL

Q6IRI3

Related

ENSRNOP00000060074.4

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:429 → 484

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_063262924.1 → XP_063118994.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X5
XM_063262918.1 → XP_063118988.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

UniProtKB/TrEMBL

Q6IRI3
XM_039078309.2 → XP_038934237.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

UniProtKB/Swiss-Prot

Q9QY17, Q9QY18, Q9QY19, Q9QY20

UniProtKB/TrEMBL

Q6IRI3

Conserved Domains (2) summary

cd07679
Location:18 → 275

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:429 → 484

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_063262923.1 → XP_063118993.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X6

UniProtKB/TrEMBL

A6HT91
XM_063262922.1 → XP_063118992.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X6

UniProtKB/TrEMBL

A6HT91
XM_063262917.1 → XP_063118987.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X4

UniProtKB/TrEMBL

Q6IRI3
XM_063262916.1 → XP_063118986.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X2
XM_039078307.2 → XP_038934235.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X3

UniProtKB/Swiss-Prot

Q9QY17, Q9QY18, Q9QY19, Q9QY20

Conserved Domains (2) summary

cd07679
Location:63 → 318

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:431 → 486

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_039078304.2 → XP_038934232.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X1

UniProtKB/Swiss-Prot

Q9QY17, Q9QY18, Q9QY19, Q9QY20

UniProtKB/TrEMBL

A0A8I6A2Y6

Related

ENSRNOP00000087304.1

Conserved Domains (2) summary

cd07679
Location:63 → 318

F-BAR_PACSIN2; The F-BAR (FES-CIP4 Homology and Bin/Amphiphysin/Rvs) domain of Protein kinase C and Casein kinase Substrate in Neurons 2 (PACSIN2)

cd11998
Location:472 → 527

SH3_PACSIN1-2; Src homology 3 domain of Protein kinase C and Casein kinase Substrate in Neurons 1 (PACSIN1) and PACSIN 2
XM_063262925.1 → XP_063118995.1 protein kinase C and casein kinase substrate in neurons 2 protein isoform X5