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Cd19 CD19 antigen [ Mus musculus (house mouse) ]

Gene ID: 12478, updated on 12-May-2024

Summary

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Official Symbol
Cd19provided by MGI
Official Full Name
CD19 antigenprovided by MGI
Primary source
MGI:MGI:88319
See related
Ensembl:ENSMUSG00000030724 AllianceGenome:MGI:88319
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Involved in several processes, including B-1 B cell differentiation; positive regulation of phosphatidylinositol 3-kinase activity; and positive regulation of release of sequestered calcium ion into cytosol. Acts upstream of or within B cell receptor signaling pathway. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in liver and spleen. Human ortholog(s) of this gene implicated in common variable immunodeficiency. Orthologous to human CD19 (CD19 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in spleen adult (RPKM 117.1), mammary gland adult (RPKM 26.5) and 2 other tissues See more
Orthologs
human all
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Genomic context

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Location:
7 F3; 7 69.01 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (126007620..126016401, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (126408448..126415148, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133521004-133521187 Neighboring gene SPNS lysolipid transporter 1, lysophospholipid Neighboring gene nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 2 interacting protein Neighboring gene STARR-seq mESC enhancer starr_20144 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133540343-133540526 Neighboring gene STARR-positive B cell enhancer ABC_E8208 Neighboring gene STARR-positive B cell enhancer ABC_E9706 Neighboring gene STARR-positive B cell enhancer ABC_E9707 Neighboring gene rabaptin, RAB GTPase binding effector protein 2 Neighboring gene ATPase, Ca++ transporting, cardiac muscle, fast twitch 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:133618829-133619012 Neighboring gene SH2B adaptor protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells. McCaleb MR, et al. Immunohorizons, 2023 Jan 1. PMID 36637517, Free PMC Article
  2. B10 cells decrease fibrosis progression following cardiac injury partially by IL-10 production and regulating hyaluronan secretion. Chen R, et al. J Leukoc Biol, 2022 Feb. PMID 34013598
  3. CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD. Imura Y, et al. JCI Insight, 2020 Jul 23. PMID 32525846, Free PMC Article
  4. Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis. Atkinson JR, et al. J Virol, 2017 Dec 1. PMID 28931676, Free PMC Article
  5. Intravital imaging of Ca(2+) signals in lymphocytes of Ca(2+) biosensor transgenic mice: indication of autoimmune diseases before the pathological onset. Yoshikawa S, et al. Sci Rep, 2016 Jan 6. PMID 26732477, Free PMC Article

See all (814) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
    Title: Enhanced efficacy of CD19/CD22 bispecific CAR-T cells with EAAAK linker on B-cell malignancies.
  2. Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24.
    Title: Enhanced CD19 activity in B cells contributes to immunodeficiency in mice deficient in the ICF syndrome gene Zbtb24.
  3. CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells.
    Title: CD19 Is Internalized Together with IgM in Proportion to B Cell Receptor Stimulation and Is Modulated by Phosphatidylinositol 3-Kinase in Bone Marrow Immature B Cells.
  4. Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19.
    Title: Host B cells escape CAR-T immunotherapy by reversible downregulation of CD19.
  5. SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.
    Title: SARS-CoV-2 infection causes immunodeficiency in recovered patients by downregulating CD19 expression in B cells via enhancing B-cell metabolism.
  6. CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
    Title: CD19-targeted CAR regulatory T cells suppress B cell pathology without GvHD.
  7. The results suggest that CD19 controls the differentiation of marginal zone precursors to marginal zone B cells by regulating ADAM28-mediated Notch2 cleavage.
    Title: CD19 regulates ADAM28-mediated Notch2 cleavage to control the differentiation of marginal zone precursors to MZ B cells.
  8. This study demonstrates that antiviral protective antibody-secreting cells (ASC) in the central nervous system are dependent on CD19 activation and peripheral Germinal Center formation, while accumulation of early-recruited IgD(+) B cells is CD19 independent.
    Title: Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis.
  9. this study shows that mitochondrial reactive oxygen species suppress humoral immune responses through reduction of CD19 expression and resultant B cell receptor signaling in B cells
    Title: Mitochondrial reactive oxygen species suppress humoral immune response through reduction of CD19 expression in B cells in mice.
  10. autoimmunity induced by excessive BAFF production requires B1b B cells and CD19 signaling.
    Title: BAFF-driven autoimmunity requires CD19 expression.
Submit: New GeneRIF Correction See all GeneRIFs (53)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in B cell mediated immunity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in B cell proliferation involved in immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in B cell receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within B cell receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in B-1 B cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in antigen receptor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
  
involved_in immunoglobulin mediated immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of release of sequestered calcium ion into cytosol IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of release of sequestered calcium ion into cytosol ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell activation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of B cell receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of B cell receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in external side of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in external side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in external side of plasma membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 PubMed 

General protein information

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Preferred Names
B-lymphocyte antigen CD19
Names
differentiation antigen CD19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001357091.2 → NP_001344020.1  B-lymphocyte antigen CD19 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC125322
    Consensus CDS
    CCDS90327.1
    UniProtKB/TrEMBL
    A0A0X1KG58, Q3U1A5
    Related
    ENSMUSP00000032968.7, ENSMUST00000032968.7
    Conserved Domains (2) summary
    smart00410
    Location:183 → 263
    IG_like; Immunoglobulin like
    cd04979
    Location:21 → 118
    Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin

  2. NM_009844.3 → NP_033974.2  B-lymphocyte antigen CD19 isoform 1 precursor

    See identical proteins and their annotated locations for NP_033974.2

    Status: VALIDATED

    Source sequence(s)
    AC125322
    Consensus CDS
    CCDS21828.1
    UniProtKB/Swiss-Prot
    P25918, Q542B2
    UniProtKB/TrEMBL
    Q3TA95
    Related
    ENSMUSP00000145803.2, ENSMUST00000206325.2
    Conserved Domains (3) summary
    cd04979
    Location:21 → 118
    Ig_Semaphorin_C; Immunoglobulin (Ig)-like domain of semaphorin
    smart00410
    Location:26 → 115
    IG_like; Immunoglobulin like
    cl11960
    Location:180 → 259
    Ig; Immunoglobulin domain

RNA

  1. NR_178083.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC125322

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    126007620..126016401 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036152614.1 → XP_036008507.1  B-lymphocyte antigen CD19 isoform X1

    UniProtKB/TrEMBL
    Q3TQG5
    Conserved Domains (2) summary
    cd00096
    Location:70 → 78
    Ig; Ig strand B [structural motif]
    cl11960
    Location:65 → 147
    Ig; Immunoglobulin domain

  2. XM_036152615.1 → XP_036008508.1  B-lymphocyte antigen CD19 isoform X2

    Related
    ENSMUST00000205997.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P25918.3 GenPept UniProtKB/Swiss-Prot:P25918

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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