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Cdh1 cadherin 1 [ Mus musculus (house mouse) ]

Gene ID: 12550, updated on 14-Jan-2025

Summary

Official Symbol
Cdh1provided by MGI
Official Full Name
cadherin 1provided by MGI
Primary source
MGI:MGI:88354
See related
Ensembl:ENSMUSG00000000303 AllianceGenome:MGI:88354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Um; UVO; Ecad; ARC-1; E-cad; L-CAM
Summary
This gene encodes E-cadherin, a calcium-dependent cell adhesion molecule that functions in the establishment and maintenance of epithelial cell morphology during embryongenesis and adulthood. The encoded preproprotein undergoes proteolytic processing to generate a mature protein. Targeted mutations disrupting binding of calcium to the encoded protein in mice cause death in utero due to failed blastocyst and trophectoderm formation. This gene is located adjacent to a related cadherin gene on chromosome 8. [provided by RefSeq, Oct 2015]
Annotation information
Note: CDH1 (GeneID 12550) and FZR1 (GeneID 56371) share the CDH1 symbol. CDH1 is sometimes used as an abbreviation for 'CDC20 homolog 1' which is an alternate name for the FZR1 gene and thus can be confused with the official symbol for cadherin 1 (CDH1). [16 Jul 2018]
Expression
Broad expression in colon adult (RPKM 139.2), large intestine adult (RPKM 100.0) and 15 other tissues See more
Orthologs
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Genomic context

See Cdh1 in Genome Data Viewer
Location:
8 D3; 8 53.18 cM
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (107329982..107396879)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (106603350..106670247)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1110028F18 gene Neighboring gene ribosomal protein, large, P1 pseudogene Neighboring gene predicted gene, 39239 Neighboring gene STARR-seq mESC enhancer starr_22570 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109171364-109171664 Neighboring gene transport and golgi organization 6 Neighboring gene STARR-seq mESC enhancer starr_22578 Neighboring gene STARR-positive B cell enhancer ABC_E10521 Neighboring gene STARR-seq mESC enhancer starr_22579 Neighboring gene STARR-positive B cell enhancer mm9_chr8:109344486-109344787 Neighboring gene predicted gene, 34197 Neighboring gene STARR-seq mESC enhancer starr_22582 Neighboring gene predicted gene, 53451 Neighboring gene hyaluronan synthase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Clone Names

  • MGC107495

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activating protein binding  
enables alpha-catenin binding PubMed 
enables ankyrin binding  
enables beta-catenin binding  
enables beta-catenin binding PubMed 
enables beta-catenin binding PubMed 
enables beta-catenin binding  
enables cadherin binding  
enables calcium ion binding PubMed 
enables cell adhesion molecule binding  
enables cytoskeletal protein binding PubMed 
enables gamma-catenin binding  
enables identical protein binding PubMed 
enables identical protein binding  
enables molecular adaptor activity PubMed 
enables molecular adaptor activity PubMed 
enables protein binding PubMed 
enables protein domain specific binding PubMed 
enables protein phosphatase binding PubMed 
enables protein tyrosine kinase binding  
Items 1 - 25 of 53
Process Evidence Code Pubs
acts_upstream_of_or_within actin cytoskeleton organization PubMed 
involved_in adherens junction organization  
involved_in adherens junction organization  
acts_upstream_of_or_within bicellular tight junction assembly PubMed 
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules  
acts_upstream_of_or_within calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules PubMed 
acts_upstream_of canonical Wnt signaling pathway PubMed 
involved_in cell migration  
involved_in cell morphogenesis  
acts_upstream_of_or_within cell-cell adhesion PubMed 
involved_in cell-cell adhesion  
involved_in cell-cell adhesion mediated by cadherin  
acts_upstream_of_or_within cell-cell adhesion mediated by cadherin PubMed 
involved_in cell-cell junction assembly  
acts_upstream_of_or_within cellular response to amino acid stimulus PubMed 
involved_in cellular response to indole-3-methanol  
involved_in cellular response to lithium ion  
involved_in cochlea development PubMed 
acts_upstream_of_or_within cochlea development PubMed 
involved_in decidualization PubMed 
involved_in embryo implantation PubMed 
acts_upstream_of_or_within epithelial cell morphogenesis PubMed 
acts_upstream_of_or_within establishment of skin barrier PubMed 
involved_in homophilic cell adhesion via plasma membrane adhesion molecules  
acts_upstream_of_or_within in utero embryonic development PubMed 
acts_upstream_of_or_within intestinal epithelial cell development PubMed 
involved_in negative regulation of axon extension  
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway PubMed 
involved_in negative regulation of cell migration  
involved_in negative regulation of cell-cell adhesion  
acts_upstream_of_or_within negative regulation of epithelial cell proliferation PubMed 
acts_upstream_of_or_within negative regulation of protein localization to plasma membrane PubMed 
acts_upstream_of_or_within negative regulation of protein processing PubMed 
involved_in positive regulation of DNA-templated transcription  
acts_upstream_of_or_within positive regulation of cell-cell adhesion PubMed 
involved_in positive regulation of protein import into nucleus  
involved_in protein localization to plasma membrane PubMed 
involved_in protein localization to plasma membrane  
acts_upstream_of_or_within protein metabolic process  
acts_upstream_of_or_within regulation of branching involved in salivary gland morphogenesis PubMed 
acts_upstream_of_or_within regulation of cysteine-type endopeptidase activity PubMed 
involved_in regulation of gene expression  
involved_in regulation of gene expression  
acts_upstream_of_or_within regulation of neuron migration PubMed 
involved_in regulation of protein catabolic process at postsynapse, modulating synaptic transmission  
acts_upstream_of_or_within regulation of protein localization PubMed 
acts_upstream_of_or_within regulation of protein localization to cell surface PubMed 
acts_upstream_of_or_within salivary gland cavitation PubMed 
acts_upstream_of_or_within sensory perception of sound PubMed 
involved_in synapse assembly  
involved_in synapse assembly  
acts_upstream_of_or_within trophectodermal cell differentiation PubMed 
involved_in uterine epithelium development PubMed 
Items 1 - 25 of 53
Items 1 - 20 of 44
Component Evidence Code Pubs
located_in Golgi apparatus  
located_in Schmidt-Lanterman incisure PubMed 
located_in actin cytoskeleton  
is_active_in adherens junction  
located_in adherens junction PubMed 
located_in adherens junction PubMed 
is_active_in apical junction complex  
located_in apical junction complex PubMed 
located_in apical junction complex  
located_in apical part of cell PubMed 
located_in axon PubMed 
located_in axon terminus PubMed 
located_in basolateral plasma membrane PubMed 
part_of catenin complex  
part_of catenin complex PubMed 
part_of catenin complex PubMed 
part_of catenin complex  
located_in cell junction  
located_in cell periphery PubMed 
located_in cell surface PubMed 
located_in cell-cell junction PubMed 
located_in cell-cell junction PubMed 
colocalizes_with cortical actin cytoskeleton  
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasmic side of plasma membrane  
located_in desmosome  
located_in endosome  
part_of flotillin complex  
part_of flotillin complex PubMed 
part_of flotillin complex  
is_active_in glutamatergic synapse  
located_in lamellipodium  
located_in lateral loop PubMed 
located_in lateral plasma membrane  
located_in membrane  
located_in microvillus PubMed 
located_in node of Ranvier PubMed 
located_in perinuclear region of cytoplasm  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
is_active_in postsynapse  
located_in trans-Golgi network  
Items 1 - 20 of 44

General protein information

Preferred Names
cadherin-1
Names
E-cadherin
epithelial cadherin
uvomorulin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_009864.3NP_033994.1  cadherin-1 preproprotein

    See identical proteins and their annotated locations for NP_033994.1

    Status: REVIEWED

    Source sequence(s)
    AC132132, AC147500, AK076369, BP765198, CF898038
    Consensus CDS
    CCDS22638.1
    UniProtKB/Swiss-Prot
    P09803, Q61377
    UniProtKB/TrEMBL
    A0A0R4IZW5, Q4KML8
    Related
    ENSMUSP00000000312.6, ENSMUST00000000312.12
    Conserved Domains (6) summary
    cd00031
    Location:160260
    CA_like; Cadherin repeat-like domain
    cd11304
    Location:268373
    Cadherin_repeat; Cadherin tandem repeat domain
    pfam00028
    Location:382461
    Cadherin; Cadherin domain
    pfam01049
    Location:743879
    Cadherin_C; Cadherin cytoplasmic region
    pfam08758
    Location:29118
    Cadherin_pro; Cadherin prodomain like
    cl09101
    Location:606688
    E_set; Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    107329982..107396879
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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