Cebpg CCAAT/enhancer binding protein gamma [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cebpgprovided by MGI
Official Full Name: CCAAT/enhancer binding protein gammaprovided by MGI
Primary source: MGI:MGI:104982
See related: Ensembl:ENSMUSG00000056216 AllianceGenome:MGI:104982
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpe1bp; Ig/EBP; GPE1-BP; C/EBP[g]; C/EBPgamma
Summary: Enables RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in enucleate erythrocyte differentiation; natural killer cell mediated cytotoxicity; and regulation of gene expression. Acts upstream of or within B cell differentiation and mRNA metabolic process. Located in nucleus. Is expressed in several structures, including blood; central nervous system; genitourinary system; retina; and yolk sac. Orthologous to human CEBPG (CCAAT enhancer binding protein gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in liver E18 (RPKM 10.2), CNS E11.5 (RPKM 8.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 7 B2; 7 20.91 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (34745847..34755991, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (35046422..35056566, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer.
Title: CEBPG suppresses ferroptosis through transcriptional control of SLC7A11 in ovarian cancer.
Systemic approaches using single cell transcriptome reveal that C/EBPgamma regulates autophagy under amino acid starved condition.
Title: Systemic approaches using single cell transcriptome reveal that C/EBPγ regulates autophagy under amino acid starved condition.
The results suggest the role of C/EBPgamma on ATF5 (activating transcription factor 5)-regulated vomeronasal sensory neurons differentiation in early postnatal development.
Title: Co-expression of C/EBPγ and ATF5 in mouse vomeronasal sensory neurons during early postnatal development.
specific deletion of Cebpg in the murine hematopoietic system did not alter hematopoietic stem and progenitor cell properties, their ability to commit to the myeloid lineage, and produce granulocytes in normal and stress conditions.
Title: C/EBPγ is dispensable for steady-state and emergency granulopoiesis.
Adult Cebpg-/- mice on a mixed strain background show increased early mortality and altered cancer incidence.
Title: C/EBPγ Is a Critical Regulator of Cellular Stress Response Networks through Heterodimerization with ATF4.
HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-kappaB, AP-1, C/EBPalpha and C/EBPgamma transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways
Title: HIV-1 Tat-mediated induction of CCL5 in astrocytes involves NF-κB, AP-1, C/EBPα and C/EBPγ transcription factors and JAK, PI3K/Akt and p38 MAPK signaling pathways.
The senescence-suppressing activity of C/EBPgamma required its ability to heterodimerize with C/EBPbeta.
Title: C/EBPγ suppresses senescence and inflammatory gene expression by heterodimerizing with C/EBPβ.
CCAAT/enhancer-binding protein gamma is a critical regulator of IL-1beta-induced IL-6 production in alveolar epithelial cells.
Title: CCAAT/enhancer-binding protein γ is a critical regulator of IL-1β-induced IL-6 production in alveolar epithelial cells.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC316377P8 (e-PCR)
- UniSTS:272975

X55499 (e-PCR)
- UniSTS:163414

PMC305797P1 (e-PCR)
- UniSTS:272565

Cebpg (e-PCR), detects polymorphism
- UniSTS:532449

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
NOT enables DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding, bending	ISO Inferred from Sequence Orthology more info
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in B cell differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	TAS Traceable Author Statement more info	PubMed
involved_in enucleate erythrocyte differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in immune response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within mRNA metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in natural killer cell mediated cytotoxicity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in nucleosome disassembly	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of DNA repair	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of type II interferon production	IMP Inferred from Mutant Phenotype more info	PubMed
NOT acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CCAAT/enhancer-binding protein gamma

Names: CCAAT/enhancer binding protein (C/EBP), gamma; G-CSF promoter element 1 binding protein; GPE1-BP (C/EBP gamma); GPE1-binding protein; IG/EBP-1; c/EBP gamma; granulocyte colony-stimulating factor promoter element 1-binding protein; immunoglobulin enhancer-binding protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_009884.3 → NP_034014.1 CCAAT/enhancer-binding protein gamma

See identical proteins and their annotated locations for NP_034014.1

Status: VALIDATED

Source sequence(s)

AC149058, AK159544, BE987706, CJ092456

Consensus CDS

CCDS21144.1

UniProtKB/Swiss-Prot

P53568

UniProtKB/TrEMBL

Q54AJ1

Related

ENSMUSP00000118588.2, ENSMUST00000130491.3

Conserved Domains (1) summary

cd14713
Location:60 → 120

bZIP_CEBPG; Basic leucine zipper (bZIP) domain of CCAAT/enhancer-binding protein gamma (CEBPG): a DNA-binding and dimerization domain