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ZNF573 zinc finger protein 573 [ Homo sapiens (human) ]

Gene ID: 126231, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF573provided by HGNC
Official Full Name
zinc finger protein 573provided by HGNC
Primary source
HGNC:HGNC:26420
See related
Ensembl:ENSG00000189144 AllianceGenome:HGNC:26420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 1.0), spleen (RPKM 0.7) and 25 other tissues See more
Orthologs
all
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Genomic context

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See ZNF573 in Genome Data Viewer
Location:
19q13.12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37738302..37779586, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40540059..40581107, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (38229203..38270226, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:38186077-38186752 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:38187429-38188103 Neighboring gene selenoprotein K pseudogene 1 Neighboring gene zinc finger protein 607 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10557 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10558 Neighboring gene H3K27ac hESC enhancers GRCh37_chr19:38269714-38270377 and GRCh37_chr19:38270378-38271040 Neighboring gene uncharacterized LOC105372394 Neighboring gene IST1 homolog Neighboring gene zinc finger protein 607 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A tumor-associated autoantibody panel for the detection of non-small cell lung cancer. Cai R, et al. Front Oncol, 2022. PMID 36531074, Free PMC Article
  2. A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome. Yao Z, et al. Mol Cell, 2017 Jan 19. PMID 28065597, Free PMC Article
  3. Mammalian APE1 controls miRNA processing and its interactome is linked to cancer RNA metabolism. Antoniali G, et al. Nat Commun, 2017 Oct 6. PMID 28986522, Free PMC Article
  4. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. Suzuki Y, et al. Genome Res, 2004 Sep. PMID 15342556, Free PMC Article
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. Abdelmohsen K, et al. EMBO J, 2009 May 6. PMID 19322201, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ30921

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 573

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172689.2 → NP_001166160.1  zinc finger protein 573 isoform 2

    See identical proteins and their annotated locations for NP_001166160.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks three alternate exons, includes an additional exon, and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AC016582, AK055483, AK074539, BC042170, DA778380
    UniProtKB/Swiss-Prot
    Q86YE8
    Conserved Domains (3) summary
    COG5048
    Location:156 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:172 → 197
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001172690.2 → NP_001166161.1  zinc finger protein 573 isoform 3

    See identical proteins and their annotated locations for NP_001166161.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks three alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (3) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055483, BC042170, BP274132
    Consensus CDS
    CCDS59381.1
    UniProtKB/Swiss-Prot
    B7WPE1, K7EJ45, Q6P1P1, Q7Z7Q3, Q86YE8, Q8N2Q1, Q96BM3, Q96NH0
    Related
    ENSP00000440464.2, ENST00000536220.7
    Conserved Domains (5) summary
    smart00349
    Location:28 → 89
    KRAB; krueppel associated box
    COG5048
    Location:244 → 628
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:584 → 604
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:28 → 67
    KRAB; KRAB box
    pfam13465
    Location:260 → 285
    zf-H2C2_2; Zinc-finger double domain

  3. NM_001172691.2 → NP_001166162.1  zinc finger protein 573 isoform 4

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks three alternate exons, uses an alternate splice site, and uses an upstream start codon, compared to variant 1. The resulting isoform (4) has a longer and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AK055483, BC042170, BG572864, DA778380
    UniProtKB/Swiss-Prot
    Q86YE8
    Conserved Domains (5) summary
    smart00349
    Location:26 → 87
    KRAB; krueppel associated box
    COG5048
    Location:242 → 626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:582 → 602
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:26 → 65
    KRAB; KRAB box
    pfam13465
    Location:258 → 283
    zf-H2C2_2; Zinc-finger double domain

  4. NM_001172692.2 → NP_001166163.1  zinc finger protein 573 isoform 2

    See identical proteins and their annotated locations for NP_001166163.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) lacks four alternate exons and uses an upstream start codon, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1. Both variants 2 and 5 encode the same isoform.
    Source sequence(s)
    AK055483, BC042170, DA778380, DB121870
    UniProtKB/Swiss-Prot
    Q86YE8
    Conserved Domains (3) summary
    COG5048
    Location:156 → 540
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:496 → 516
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:172 → 197
    zf-H2C2_2; Zinc-finger double domain

  5. NM_152360.4 → NP_689573.3  zinc finger protein 573 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AK055483, BC064962, DA778380
    Consensus CDS
    CCDS12508.1
    UniProtKB/Swiss-Prot
    Q86YE8
    Related
    ENSP00000340171.4, ENST00000339503.7
    Conserved Domains (4) summary
    COG5048
    Location:186 → 570
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:526 → 546
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:202 → 227
    zf-H2C2_2; Zinc-finger double domain
    pfam13900
    Location:6 → 34
    GVQW; Putative domain of unknown function

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37738302..37779586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40540059..40581107 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YE8.4 GenPept UniProtKB/Swiss-Prot:Q86YE8

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