Protein interactions
Protein |
Gene |
Interaction |
Pubs |
Envelope surface glycoprotein gp120
|
env
|
Upregulation of the human proteins CCL2, CX3CL1, IL-1beta, and CXCL10 by HIV-1 gp120 involves CB2 receptor in mesencephalic neuronal/glial culture model |
PubMed
|
|
env
|
CB1 or CB2 receptor agonists significantly inhibit HIV-1 gp120-induced decrease proliferation and increase apoptosis of human neural progenitor cells (hNPCs), indicating that CB1 or CB2 receptors are required for the effects of gp120 on hNPCs |
PubMed
|
|
env
|
HIV-1 gp120-induced synapse loss is inhibited by activation of CB2 receptor |
PubMed
|
Tat
|
tat
|
CB1 and CB2 endocannabinoid receptors are involved in HIV-1 Tat-induced cleavage of PARP1 and CASP3 in retinal cells |
PubMed
|
|
tat
|
Treatment with cannabinoids inhibits HIV-1 Tat-enhanced attachment of U937 cells to collagen IV, laminin, or ECM1 proteins, which is linked to the cannabinoid receptor type 2 and the modulation of beta1-integrin and actin distribution |
PubMed
|
|
tat
|
HIV-1 Tat upregulates the expression of CB1 and CB2 cannabinoid receptors in retinal cells, which is suppressed by endocannabinoids, N-arachidonoylethanolamide and 2-arachidonoylglycerol |
PubMed
|
|
tat
|
CB(2) cannabinoid receptor 2 is involved in HIV-1 Tat-mediated macrophage migration |
PubMed
|
|
tat
|
HIV-1 Tat-mediated activation of the CB2R leads to altered expression and compartmentation of the beta-chemokine receptor CCR-3 |
PubMed
|
capsid
|
gag
|
Monocyte-derived macrophages treated during differentiation with a CB2 specific agonist show decrease in p24 levels |
PubMed
|
Go to the HIV-1, Human Interaction Database