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LOC1278659 serine hydroxymethyltransferase [ Anopheles gambiae (African malaria mosquito) ]

Gene ID: 1278659, updated on 4-Jan-2024

Summary

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Gene symbol
LOC1278659
Gene description
serine hydroxymethyltransferase
Gene type
protein coding
RefSeq status
MODEL
Organism
Anopheles gambiae
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Nematocera; Culicoidea; Culicidae; Anophelinae; Anopheles
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Genomic context

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Location:
chromosome: X
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_12 current idAnoGambNW_F1_1 (GCF_943734735.2) X NC_064600.1 (22916051..22922700, complement)

Chromosome X - NC_064600.1Genomic Context describing neighboring genes Neighboring gene espin Neighboring gene putative nuclease HARBI1 Neighboring gene uncharacterized LOC133391088 Neighboring gene transmembrane emp24 domain-containing protein bai Neighboring gene uncharacterized LOC133391089

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_064600.1 Chromosome X Reference idAnoGambNW_F1_1 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut. Liu S, et al. Proc Natl Acad Sci U S A, 2014 Oct 7. PMID 25246546, Free PMC Article
  2. The Anopheles gambiae genome: an update. Mongin E, et al. Trends Parasitol, 2004 Feb. PMID 14747013
  3. The genome sequence of the malaria mosquito Anopheles gambiae. Holt RA, et al. Science, 2002 Oct 4. PMID 12364791

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that serine hydroxymethyltransferase (SHMT) is a direct miR-1174 target.
    Title: Mosquito-specific microRNA-1174 targets serine hydroxymethyltransferase to control key functions in the gut.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables cobalt ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables glycine hydroxymethyltransferase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA 5'-UTR binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables serine binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in L-serine catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in folic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in glycine biosynthetic process from serine IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein homotetramerization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in purine nucleobase biosynthetic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in tetrahydrofolate interconversion IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cytosol IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
serine hydroxymethyltransferase

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_943734735.2-RS_2023_12

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference idAnoGambNW_F1_1 Primary Assembly

Genomic

  1. NC_064600.1 Reference idAnoGambNW_F1_1 Primary Assembly

    Range
    22916051..22922700 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_003437154.2 → XP_003437202.2  serine hydroxymethyltransferase isoform X1

  2. XM_061641361.1 → XP_061497345.1  serine hydroxymethyltransferase isoform X1

  3. XM_003437151.2 → XP_003437199.2  serine hydroxymethyltransferase isoform X2

  4. XM_003437149.2 → XP_003437197.2  serine hydroxymethyltransferase isoform X3

Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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Molecular Biology Databases
Research Materials