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ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide [ Homo sapiens (human) ]

Gene ID: 128, updated on 4-Jan-2025

Summary

Official Symbol
ADH5provided by HGNC
Official Full Name
alcohol dehydrogenase 5 (class III), chi polypeptideprovided by HGNC
Primary source
HGNC:HGNC:253
See related
Ensembl:ENSG00000197894 MIM:103710; AllianceGenome:HGNC:253
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FDH; ADHX; ADH-3; AMEDS; BMFS7; FALDH; GSNOR; GSH-FDH; HEL-S-60p
Summary
This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]
Expression
Ubiquitous expression in endometrium (RPKM 69.1), kidney (RPKM 68.7) and 25 other tissues See more
Orthologs
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Genomic context

See ADH5 in Genome Data Viewer
Location:
4q23
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (99070978..99088788, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (102385880..102403688, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (99992129..100009939, complement)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124900738 Neighboring gene methionyl aminopeptidase 1 Neighboring gene activator of basal transcription 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21737 Neighboring gene ADH5 promoter Neighboring gene uncharacterized LOC100507053 Neighboring gene Sharpr-MPRA regulatory region 12553 Neighboring gene uncharacterized LOC124900739 Neighboring gene ADH4 promoter Neighboring gene alcohol dehydrogenase 4 (class II), pi polypeptide

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
AMED syndrome, digenic
MedGen: C5436906 OMIM: 619151 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
Discovery and refinement of loci associated with lipid levels.
EBI GWAS Catalog
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.
EBI GWAS Catalog
Genome-wide association study of smoking behaviours among Bangladeshi adults.
EBI GWAS Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

General gene information

Clone Names

  • FLJ43004

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in fatty acid omega-oxidation PubMed 
involved_in formaldehyde catabolic process  
involved_in positive regulation of blood pressure  
involved_in respiratory system process  
involved_in response to lipopolysaccharide  
involved_in response to nitrosative stress  
involved_in response to redox state PubMed 
involved_in retinoid metabolic process  
Component Evidence Code Pubs
is_active_in cytosol  
located_in cytosol  
located_in extracellular exosome PubMed 
located_in mitochondrion  

General protein information

Preferred Names
alcohol dehydrogenase class-3
Names
S-(hydroxymethyl)glutathione dehydrogenase
S-nitrosoglutathione reductase
alcohol dehydrogenase (class III), chi polypeptide
alcohol dehydrogenase class chi chain
alcohol dehydrogenase class-III
epididymis secretory sperm binding protein Li 60p
formaldehyde dehydrogenase
glutathione-dependent formaldehyde dehydrogenase
NP_000662.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_000671.4NP_000662.3  alcohol dehydrogenase class-3

    See identical proteins and their annotated locations for NP_000662.3

    Status: REVIEWED

    Source sequence(s)
    AC019131, DA737788, M30471
    Consensus CDS
    CCDS47111.1
    UniProtKB/Swiss-Prot
    P11766, Q6FHR2
    UniProtKB/TrEMBL
    A0A024RDI2, Q5U043, Q6FI45, Q6IRT1
    Related
    ENSP00000296412.8, ENST00000296412.14
    Conserved Domains (1) summary
    cd08300
    Location:6373
    alcohol_DH_class_III; class III alcohol dehydrogenases

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

    Range
    99070978..99088788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060928.1 Alternate T2T-CHM13v2.0

    Range
    102385880..102403688 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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