U.S. flag

An official website of the United States government

Cp ceruloplasmin [ Mus musculus (house mouse) ]

Gene ID: 12870, updated on 13-Jan-2025

Summary

Official Symbol
Cpprovided by MGI
Official Full Name
ceruloplasminprovided by MGI
Primary source
MGI:MGI:88476
See related
Ensembl:ENSMUSG00000003617 AllianceGenome:MGI:88476
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D3Ertd555e
Summary
The protein encoded by this gene is a copper-containing glycoprotein found soluble in the serum and GPI-anchored in other tissues. It oxidizes Fe(II) to Fe(III) and is proposed to play an important role in iron homeostasis. In humans mutations of this gene cause aceruloplasminemia, which is characterized by retinal degeneration, diabetes, anemia and neurological symptoms. In mouse deficiency of this gene in combination with a deficiency of its homolog hephaestin causes retinal degeneration and serves as a pathophysiological model for aceruloplasminemia and age-related macular degeneration. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jan 2013]
Expression
Biased expression in liver adult (RPKM 26.7), liver E18 (RPKM 23.8) and 8 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Location:
3 A2; 3 6.1 cM
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (20011097..20063914)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (19956933..20009750)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 17771 Neighboring gene predicted gene, 42190 Neighboring gene STARR-seq mESC enhancer starr_07104 Neighboring gene HPS3, biogenesis of lysosomal organelles complex 2 subunit 1 Neighboring gene STARR-seq mESC enhancer starr_07105 Neighboring gene STARR-positive B cell enhancer ABC_E3428 Neighboring gene STARR-seq mESC enhancer starr_07106 Neighboring gene STARR-seq mESC enhancer starr_07107 Neighboring gene STARR-positive B cell enhancer ABC_E1018 Neighboring gene helicase-like transcription factor Neighboring gene STARR-seq mESC enhancer starr_07108 Neighboring gene VISTA enhancer mm86 Neighboring gene glycogenin 1

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables copper ion binding PubMed 
enables copper ion binding  
enables ferroxidase activity PubMed 
enables ferroxidase activity  
enables ferroxidase activity  
enables glutathione peroxidase activity  
enables glutathione peroxidase activity  
enables oxidoreductase activity  
enables oxidoreductase activity, acting on metal ions, oxygen as acceptor  
enables oxidoreductase activity, acting on metal ions, oxygen as acceptor  
enables phospholipid-hydroperoxide glutathione peroxidase activity  
enables phospholipid-hydroperoxide glutathione peroxidase activity  
enables protein-folding chaperone binding  
Process Evidence Code Pubs
involved_in cellular oxidant detoxification  
involved_in intracellular copper ion homeostasis  
involved_in intracellular copper ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in intracellular iron ion homeostasis  
involved_in iron ion transport  
involved_in response to copper ion  
Component Evidence Code Pubs
located_in cell surface  
located_in extracellular space PubMed 
located_in extracellular space PubMed 
located_in extracellular space  
located_in extracellular space  
is_active_in plasma membrane  

General protein information

Preferred Names
ceruloplasmin
Names
cuproxidase ceruloplasmin
ferroxidase
ferroxidase ceruloplasmin
glutathione peroxidase ceruloplasmin
glutathione-dependent peroxiredoxin ceruloplasmin
NP_001263177.1
NP_001263179.1
NP_001361606.1
NP_001396575.1
NP_001396576.1
NP_001396577.1
NP_001396578.1
NP_001396579.1
NP_001396580.1
NP_031778.2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276248.2NP_001263177.1  ceruloplasmin isoform c precursor

    See identical proteins and their annotated locations for NP_001263177.1

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS71227.1
    UniProtKB/TrEMBL
    G3X8Q5
    Related
    ENSMUSP00000103964.2, ENSMUST00000108328.8
    Conserved Domains (5) summary
    cd04224
    Location:369566
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:726896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22201
    Cupredoxin; Cupredoxin superfamily
  2. NM_001276250.2NP_001263179.1  ceruloplasmin isoform c precursor

    See identical proteins and their annotated locations for NP_001263179.1

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS71227.1
    UniProtKB/TrEMBL
    G3X8Q5
    Related
    ENSMUSP00000003714.7, ENSMUST00000003714.13
    Conserved Domains (5) summary
    cd04224
    Location:369566
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:726896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22201
    Cupredoxin; Cupredoxin superfamily
  3. NM_001374677.1NP_001361606.1  ceruloplasmin isoform d precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS89616.1
    UniProtKB/TrEMBL
    G3X9T8
    Related
    ENSMUSP00000103961.3, ENSMUST00000108325.9
    Conserved Domains (5) summary
    cd04224
    Location:369566
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:726896
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:569712
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22201
    Cupredoxin; Cupredoxin superfamily
  4. NM_001409646.1NP_001396575.1  ceruloplasmin isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
    UniProtKB/TrEMBL
    E9PZD8
    Related
    ENSMUSP00000103965.2, ENSMUST00000108329.8
  5. NM_001409647.1NP_001396576.1  ceruloplasmin isoform a precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
    UniProtKB/TrEMBL
    E9PZD8
  6. NM_001409648.1NP_001396577.1  ceruloplasmin isoform e precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
  7. NM_001409649.1NP_001396578.1  ceruloplasmin isoform f precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
  8. NM_001409650.1NP_001396579.1  ceruloplasmin isoform g precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
  9. NM_001409651.1NP_001396580.1  ceruloplasmin isoform h precursor

    Status: REVIEWED

    Source sequence(s)
    AC079442
  10. NM_007752.4NP_031778.2  ceruloplasmin isoform b precursor

    See identical proteins and their annotated locations for NP_031778.2

    Status: REVIEWED

    Source sequence(s)
    AC079442
    Consensus CDS
    CCDS38401.1
    UniProtKB/Swiss-Prot
    Q61147, Q6P5C8
    Related
    ENSMUSP00000088857.6, ENSMUST00000091309.12
    Conserved Domains (5) summary
    cd04224
    Location:369567
    CuRO_3_ceruloplasmin; The third cupredoxin domain of Ceruloplasmin
    cd04225
    Location:727897
    CuRO_5_ceruloplasmin; The fifth cupredoxin domain of Ceruloplasmin
    cd11021
    Location:213353
    CuRO_2_ceruloplasmin; The second cupredoxin domain of Ceruloplasmin
    cd11022
    Location:570713
    CuRO_4_ceruloplasmin; The fourth cupredoxin domain of Ceruloplasmin
    cl19115
    Location:22201
    Cupredoxin; Cupredoxin superfamily

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    20011097..20063914
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_004941272.1 RNA Sequence

  2. XR_004941273.1 RNA Sequence

External link. Please review our privacy policy.