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Cryaa crystallin, alpha A [ Mus musculus (house mouse) ]

Gene ID: 12954, updated on 4-Jan-2025

Summary

Official Symbol
Cryaaprovided by MGI
Official Full Name
crystallin, alpha Aprovided by MGI
Primary source
MGI:MGI:88515
See related
Ensembl:ENSMUSG00000024041 AllianceGenome:MGI:88515
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Crya1; lop18; Acry-1; Crya-1; DAcry-1
Summary
This gene encodes subunit a, one of two subunits of alpha-crystallin, which is a high molecular weight, soluble aggregate and is a member of the small heat shock protein (sHSP) family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. It acts as a molecular chaperone and is the major protein in the eye lens, maintaining the transparency and refractive index of the lens. In mouse, deficiency in this gene is associated with smaller lenses and eyes and with increasing lens opacity with age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]
Expression
Biased expression in placenta adult (RPKM 1.1), lung adult (RPKM 1.0) and 8 other tissues See more
Orthologs
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Genomic context

See Cryaa in Genome Data Viewer
Location:
17 B1; 17 17.09 cM
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (31896905..31900704)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (31677931..31681730)

Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene ribosomal protein S2, pseudogene 8 Neighboring gene U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:31795932-31796115 Neighboring gene predicted gene, 30187 Neighboring gene predicted gene, 30255

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding  
enables metal ion binding  
enables protein binding PubMed 
enables structural constituent of eye lens PubMed 
enables structural molecule activity  
enables unfolded protein binding  
enables unfolded protein binding  
Items 1 - 25 of 30
Process Evidence Code Pubs
acts_upstream_of_or_within actin filament organization PubMed 
acts_upstream_of_or_within apoptotic process PubMed 
acts_upstream_of_or_within apoptotic process involved in morphogenesis PubMed 
acts_upstream_of_or_within camera-type eye development PubMed 
acts_upstream_of_or_within embryonic camera-type eye morphogenesis PubMed 
involved_in lens development in camera-type eye  
acts_upstream_of_or_within lens development in camera-type eye PubMed 
acts_upstream_of_or_within lens development in camera-type eye PubMed 
acts_upstream_of_or_within lens fiber cell morphogenesis PubMed 
acts_upstream_of_or_within lens morphogenesis in camera-type eye PubMed 
acts_upstream_of_or_within microtubule-based process PubMed 
acts_upstream_of_or_within mitochondrion organization PubMed 
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of apoptotic process PubMed 
involved_in negative regulation of apoptotic process  
acts_upstream_of_or_within negative regulation of cysteine-type endopeptidase activity PubMed 
acts_upstream_of_or_within negative regulation of gene expression PubMed 
involved_in negative regulation of intracellular transport  
acts_upstream_of_or_within positive regulation of cell growth PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation PubMed 
involved_in protein folding  
involved_in protein refolding  
involved_in protein stabilization  
acts_upstream_of_or_within response to UV-A PubMed 
involved_in response to heat  
acts_upstream_of_or_within response to hydrogen peroxide PubMed 
involved_in response to hydrogen peroxide  
acts_upstream_of_or_within response to hypoxia PubMed 
acts_upstream_of_or_within tubulin complex assembly PubMed 
involved_in visual perception  
Items 1 - 25 of 30
Component Evidence Code Pubs
is_active_in cytoplasm  
located_in cytoplasm PubMed 
located_in cytoplasm  
located_in cytosol  
located_in nucleoplasm  
is_active_in nucleus  
located_in nucleus  
located_in nucleus  
part_of protein-containing complex  

General protein information

Preferred Names
alpha-crystallin A chain
Names
crystallin, alpha 1
lens opacity 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001278569.1NP_001265498.1  alpha-crystallin A chain isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BB371615, BY114969, CA452236, CX734348, EL605017
    Consensus CDS
    CCDS89060.1
    UniProtKB/TrEMBL
    A0A494B9Q6
    Related
    ENSMUSP00000157708.2, ENSMUST00000228089.3
    Conserved Domains (3) summary
    COG0071
    Location:93174
    IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]
    pfam00525
    Location:150
    Crystallin; Alpha crystallin A chain, N terminal
    cl00175
    Location:90174
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.
  2. NM_001278570.1NP_001265499.1  alpha-crystallin A chain isoform 3

    See identical proteins and their annotated locations for NP_001265499.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame exon in the coding region compared to variant 1. It encodes isoform 3 which is shorter compared to isoform 1.
    Source sequence(s)
    AK143463, BB371615, EL604937
    Consensus CDS
    CCDS89061.1
    UniProtKB/TrEMBL
    Q569M7
    Related
    ENSMUSP00000154747.2, ENSMUST00000228716.3
    Conserved Domains (2) summary
    cd06497
    Location:60145
    ACD_alphaA-crystallin_HspB4; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaA-crystallin (HspB4, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:151
    Crystallin; Alpha crystallin A chain, N terminal
  3. NM_013501.3NP_038529.1  alpha-crystallin A chain isoform 2

    See identical proteins and their annotated locations for NP_038529.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. It encodes isoform 2, also known as alpha-A-ins, which is shorter compared to isoform 1.
    Source sequence(s)
    BB371615, BC085170, EL605017
    Consensus CDS
    CCDS37551.1
    UniProtKB/Swiss-Prot
    P24622, Q6LEL4
    UniProtKB/TrEMBL
    Q546L9
    Related
    ENSMUSP00000019192.6, ENSMUST00000019192.8
    Conserved Domains (3) summary
    COG0071
    Location:84168
    IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]
    pfam00525
    Location:150
    Crystallin; Alpha crystallin A chain, N terminal
    cl00175
    Location:86168
    alpha-crystallin-Hsps_p23-like; alpha-crystallin domain (ACD) found in alpha-crystallin-type small heat shock proteins, and a similar domain found in p23 (a cochaperone for Hsp90) and in other p23-like proteins.

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000083.7 Reference GRCm39 C57BL/6J

    Range
    31896905..31900704
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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