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Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B [ Mus musculus (house mouse) ]

Gene ID: 13118, updated on 27-Feb-2024

Summary

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Official Symbol
Cyp4a12bprovided by MGI
Official Full Name
cytochrome P450, family 4, subfamily a, polypeptide 12Bprovided by MGI
Primary source
MGI:MGI:3611747
See related
Ensembl:ENSMUSG00000078597 AllianceGenome:MGI:3611747
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cyp4a12
Summary
Enables arachidonic acid omega-hydroxylase activity. Involved in omega-hydroxylase P450 pathway. Predicted to be located in apical plasma membrane; endoplasmic reticulum membrane; and extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in metanephros; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in liver E18 (RPKM 10.9), genital fat pad adult (RPKM 3.6) and 3 other tissues See more
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Genomic context

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See Cyp4a12b in Genome Data Viewer
Location:
4 D1; 4 52.99 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115268821..115296231)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (115411624..115439034)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 12a Neighboring gene predicted gene, 52675 Neighboring gene STARR-seq mESC enhancer starr_11114 Neighboring gene STARR-seq mESC enhancer starr_11115 Neighboring gene cytochrome P450, family 4, subfamily a, member 30, pseudogene Neighboring gene STARR-seq mESC enhancer starr_11117 Neighboring gene STARR-seq mESC enhancer starr_11118 Neighboring gene STARR-seq mESC enhancer starr_11119 Neighboring gene predicted gene 12837 Neighboring gene cytochrome P450, family 4, subfamily a, polypeptide 30b Neighboring gene predicted gene 12833

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta. Le Bouquin R, et al. Fundam Clin Pharmacol, 2004 Apr. PMID 15066132
  2. Peroxisome proliferator activated receptor alpha regulates a male-specific cytochrome P450 in mouse liver. Jeffery B, et al. Arch Biochem Biophys, 2004 Sep 15. PMID 15313227
  3. Mouse Cyp4a isoforms: enzymatic properties, gender- and strain-specific expression, and role in renal 20-hydroxyeicosatetraenoic acid formation. Muller DN, et al. Biochem J, 2007 Apr 1. PMID 17112342, Free PMC Article
  4. A novel murine P-450 gene, Cyp4a14, is part of a cluster of Cyp4a and Cyp4b, but not of CYP4F, genes in mouse and humans. Heng YM, et al. Biochem J, 1997 Aug 1. PMID 9271096, Free PMC Article
  5. Species-specific induction of cytochrome P-450 4A RNAs: PCR cloning of partial guinea-pig, human and mouse CYP4A cDNAs. Bell DR, et al. Biochem J, 1993 Aug 15. PMID 8363569, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 16-hydroxypalmitate dehydrogenase activity ISO
Inferred from Sequence Orthology
more info
  
enables alkane 1-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables alkane 1-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid epoxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables arachidonic acid monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arachidonic acid omega-hydroxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables aromatase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables leukotriene-B4 20-monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables long-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables medium-chain fatty acid omega-hydroxylase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity ISO
Inferred from Sequence Orthology
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in arachidonic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in arachidonic acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in fatty acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in icosanoid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in kidney development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lauric acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lauric acid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in linoleic acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in omega-hydroxylase P450 pathway IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
  
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
  
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
cytochrome P450 4A12B
Names
cytochrome P450, family 4, subfamily a family
cytochrome P450, family 4, subfamily a, polypeptide 12
NP_758510.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_172306.2 → NP_758510.2  cytochrome P450 4A12B precursor

    Status: VALIDATED

    Source sequence(s)
    AK098123, BB665127, BC060945
    Consensus CDS
    CCDS18490.1
    UniProtKB/Swiss-Prot
    A2A974
    UniProtKB/TrEMBL
    B0G0Y1
    Related
    ENSMUSP00000092487.4, ENSMUST00000094887.4
    Conserved Domains (1) summary
    cd20678
    Location:70 → 503
    CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    115268821..115296231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_007821.2: Suppressed sequence

    Description
    NM_007821.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2A974.1 GenPept UniProtKB/Swiss-Prot:A2A974

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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