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Dag1 dystroglycan 1 [ Mus musculus (house mouse) ]

Gene ID: 13138, updated on 4-Jan-2025

Summary

Official Symbol
Dag1provided by MGI
Official Full Name
dystroglycan 1provided by MGI
Primary source
MGI:MGI:101864
See related
Ensembl:ENSMUSG00000039952 AllianceGenome:MGI:101864
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
DG; Dp71; Dp427; D9Wsu13e
Summary
This gene encodes dystroglycan, a central component of dystrophin-glycoprotein complex that links the extracellular matrix and the cytoskeleton in the skeletal muscle. The encoded preproprotein undergoes O- and N-glycosylation, and proteolytic processing to generate alpha and beta subunits. A complete lack of the encoded protein in mice results in embryonic lethality due to the disorganization of Reichert's membrane. Chimeric mice deficient in the encoded protein overcome embryonic lethality but develop a progressive muscular dystrophy. Alternative splicing results in multiple transcript variants, all encoding the same protein. [provided by RefSeq, Nov 2015]
Expression
Ubiquitous expression in lung adult (RPKM 57.8), heart adult (RPKM 42.9) and 28 other tissues See more
Orthologs
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Genomic context

See Dag1 in Genome Data Viewer
Location:
9 F1- F2; 9 59.08 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108082060..108141176, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108204861..108263977, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene bassoon Neighboring gene RIKEN cDNA 4930447F24 gene Neighboring gene glycine cleavage system protein H (aminomethyl carrier) pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E2306 Neighboring gene STARR-positive B cell enhancer ABC_E6804 Neighboring gene STARR-positive B cell enhancer ABC_E8316 Neighboring gene STARR-positive B cell enhancer ABC_E2915 Neighboring gene nicolin 1 Neighboring gene aminomethyltransferase

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 
  • Targeted (9)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables SH2 domain binding  
enables SH2 domain binding  
enables actin binding  
enables actin binding  
enables alpha-actinin binding  
enables alpha-actinin binding  
enables calcium ion binding  
enables dystroglycan binding PubMed 
enables laminin binding  
enables laminin binding PubMed 
enables laminin binding  
enables laminin-1 binding  
enables laminin-1 binding  
enables protein binding PubMed 
enables protein-containing complex binding PubMed 
enables structural constituent of muscle  
enables structural constituent of muscle  
enables tubulin binding  
enables tubulin binding  
enables vinculin binding  
enables vinculin binding  
enables virus receptor activity  
enables virus receptor activity  
Items 1 - 25 of 57
Process Evidence Code Pubs
involved_in Schwann cell development PubMed 
involved_in angiogenesis involved in wound healing  
involved_in axon guidance  
involved_in axon regeneration  
acts_upstream_of_or_within basement membrane organization PubMed 
acts_upstream_of_or_within branching involved in salivary gland morphogenesis PubMed 
involved_in calcium-dependent cell-matrix adhesion  
involved_in calcium-dependent cell-matrix adhesion  
involved_in cellular response to cholesterol  
involved_in cellular response to mechanical stimulus  
involved_in cellular response to mechanical stimulus  
acts_upstream_of_or_within cellular response to organic cyclic compound PubMed 
acts_upstream_of_or_within commissural neuron axon guidance PubMed 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis PubMed 
acts_upstream_of_or_within heart development PubMed 
acts_upstream_of_or_within heart morphogenesis PubMed 
involved_in membrane protein ectodomain proteolysis  
involved_in membrane protein ectodomain proteolysis  
involved_in microtubule anchoring  
involved_in microtubule anchoring  
acts_upstream_of_or_within morphogenesis of an epithelial sheet PubMed 
involved_in morphogenesis of an epithelium  
involved_in muscle attachment  
involved_in myelination in peripheral nervous system PubMed 
involved_in negative regulation of MAPK cascade  
involved_in negative regulation of MAPK cascade  
involved_in negative regulation of cell migration  
involved_in negative regulation of cell migration  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  
involved_in nerve development  
involved_in nerve maturation PubMed 
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
involved_in positive regulation of basement membrane assembly involved in embryonic body morphogenesis  
involved_in positive regulation of cell-matrix adhesion  
involved_in positive regulation of cell-matrix adhesion  
involved_in positive regulation of myelination  
involved_in positive regulation of myelination  
involved_in positive regulation of oligodendrocyte differentiation  
involved_in positive regulation of oligodendrocyte differentiation  
acts_upstream_of_or_within protein transport PubMed 
involved_in regulation of epithelial to mesenchymal transition  
involved_in regulation of epithelial to mesenchymal transition  
involved_in regulation of gastrulation  
involved_in regulation of gastrulation  
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
involved_in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane PubMed 
involved_in regulation of synapse organization PubMed 
involved_in regulation of synapse organization PubMed 
acts_upstream_of_or_within regulation of synaptic plasticity PubMed 
involved_in response to denervation involved in regulation of muscle adaptation  
acts_upstream_of_or_within response to muscle activity PubMed 
involved_in response to peptide hormone  
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex PubMed 
involved_in retrograde trans-synaptic signaling by trans-synaptic protein complex PubMed 
involved_in skeletal muscle tissue regeneration  
involved_in symbiont entry into host cell  
Items 1 - 25 of 57
Items 1 - 20 of 57
Component Evidence Code Pubs
is_active_in GABA-ergic synapse PubMed 
is_active_in GABA-ergic synapse PubMed 
located_in adherens junction  
located_in adherens junction  
is_active_in basement membrane  
located_in basement membrane PubMed 
located_in basement membrane  
located_in basolateral plasma membrane  
located_in basolateral plasma membrane  
is_active_in cell surface PubMed 
located_in cell-cell junction PubMed 
located_in contractile ring  
located_in contractile ring  
located_in costamere  
located_in costamere  
located_in cytoplasm  
located_in cytoskeleton  
part_of dystroglycan complex  
part_of dystroglycan complex PubMed 
part_of dystroglycan complex PubMed 
part_of dystrophin-associated glycoprotein complex  
located_in external side of plasma membrane PubMed 
located_in extracellular region  
located_in extracellular space PubMed 
is_active_in extracellular space  
located_in extracellular space  
located_in filopodium  
located_in filopodium  
located_in focal adhesion  
colocalizes_with focal adhesion  
located_in focal adhesion  
located_in glutamatergic synapse  
is_active_in glutamatergic synapse  
located_in intracellular membrane-bounded organelle  
located_in lamellipodium  
located_in lamellipodium  
located_in membrane PubMed 
located_in membrane  
located_in membrane raft PubMed 
located_in node of Ranvier PubMed 
located_in nuclear periphery  
located_in nuclear periphery  
located_in nucleoplasm  
located_in nucleoplasm  
is_active_in photoreceptor ribbon synapse PubMed 
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
located_in plasma membrane raft  
located_in plasma membrane raft  
is_active_in postsynapse PubMed 
located_in postsynaptic cytosol  
is_active_in postsynaptic cytosol  
located_in postsynaptic membrane  
is_active_in sarcolemma  
located_in sarcolemma PubMed 
located_in sarcolemma  
Items 1 - 20 of 57

General protein information

Preferred Names
dystroglycan 1
Names
dystrophin associated glycoprotein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276481.1NP_001263410.1  dystroglycan 1 preproprotein

    See identical proteins and their annotated locations for NP_001263410.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CA327718, CB289895, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  2. NM_001276482.1NP_001263411.1  dystroglycan 1 preproprotein

    See identical proteins and their annotated locations for NP_001263411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CB289895, CD578569, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Related
    ENSMUSP00000079294.3, ENSMUST00000080435.9
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  3. NM_001276485.1NP_001263414.1  dystroglycan 1 preproprotein

    See identical proteins and their annotated locations for NP_001263414.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AK053886, AV085570, CJ130634, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Related
    ENSMUSP00000128531.2, ENSMUST00000166905.8
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  4. NM_001276486.1NP_001263415.1  dystroglycan 1 preproprotein

    See identical proteins and their annotated locations for NP_001263415.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK036174, AK038702, AV085570, CJ130634, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Related
    ENSMUSP00000142109.2, ENSMUST00000191899.6
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  5. NM_001276492.1NP_001263421.1  dystroglycan 1 preproprotein

    See identical proteins and their annotated locations for NP_001263421.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK036174, AK038702, AV085570, BY256937, CB289895, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  6. NM_001276493.1NP_001263422.1  dystroglycan 1 preproprotein

    See identical proteins and their annotated locations for NP_001263422.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, compared to variant 1. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CB289895, CJ106897, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  7. NM_010017.4NP_034147.1  dystroglycan 1 preproprotein

    See identical proteins and their annotated locations for NP_034147.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-8 encode the same protein.
    Source sequence(s)
    AC168217, AK038702, AV085570, CB289895, U43512
    Consensus CDS
    CCDS23518.1
    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Related
    ENSMUSP00000130626.2, ENSMUST00000171412.7
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    108082060..108141176 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030244041.2XP_030099901.1  dystroglycan 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  2. XM_006511636.4XP_006511699.1  dystroglycan 1 isoform X1

    See identical proteins and their annotated locations for XP_006511699.1

    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2
  3. XM_030244040.2XP_030099900.1  dystroglycan 1 isoform X1

    UniProtKB/Swiss-Prot
    Q61094, Q61141, Q61497, Q62165
    UniProtKB/TrEMBL
    Q544G5, Q8BPJ7
    Conserved Domains (4) summary
    cd11303
    Location:60161
    Dystroglycan_repeat; Cadherin-like repeat domain of alpha dystroglycan
    PRK14971
    Location:301414
    PRK14971; DNA polymerase III subunit gamma/tau
    pfam05454
    Location:604893
    DAG1; Dystroglycan (Dystrophin-associated glycoprotein 1)
    pfam18424
    Location:180302
    a_DG1_N2; Alpha-Dystroglycan N-terminal domain 2

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