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CPB2 carboxypeptidase B2 [ Homo sapiens (human) ]

Gene ID: 1361, updated on 4-Jan-2025

Summary

Official Symbol
CPB2provided by HGNC
Official Full Name
carboxypeptidase B2provided by HGNC
Primary source
HGNC:HGNC:2300
See related
Ensembl:ENSG00000080618 MIM:603101; AllianceGenome:HGNC:2300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CPU; PCPB; TAFI
Summary
Carboxypeptidases are enzymes that hydrolyze C-terminal peptide bonds. The carboxypeptidase family includes metallo-, serine, and cysteine carboxypeptidases. According to their substrate specificity, these enzymes are referred to as carboxypeptidase A (cleaving aliphatic residues) or carboxypeptidase B (cleaving basic amino residues). The protein encoded by this gene is activated by trypsin and acts on carboxypeptidase B substrates. After thrombin activation, the mature protein downregulates fibrinolysis. Polymorphisms have been described for this gene and its promoter region. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2013]
Expression
Restricted expression toward liver (RPKM 288.0) See more
Orthologs
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Genomic context

See CPB2 in Genome Data Viewer
Location:
13q14.13
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (46053186..46105033, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (45274576..45326411, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (46627321..46679168, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105370191 Neighboring gene zinc finger CCCH-type containing 13 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:46626065-46626601 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr13:46626602-46627137 Neighboring gene CPB2 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7686 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7687 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7688 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:46660879-46661378 Neighboring gene Sharpr-MPRA regulatory region 4806 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7689 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7690 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr13:46724131-46725330 Neighboring gene lymphocyte cytosolic protein 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7691 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7692 Neighboring gene RNA, 7SL, cytoplasmic 288, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7693 Neighboring gene uncharacterized LOC107984578 Neighboring gene uncharacterized LOC105370192

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metallocarboxypeptidase activity  
enables zinc ion binding  
Process Evidence Code Pubs
involved_in blood coagulation  
involved_in cellular response to glucose stimulus  
involved_in fibrinolysis  
involved_in liver regeneration  
involved_in negative regulation of fibrinolysis  
involved_in negative regulation of hepatocyte proliferation  
involved_in negative regulation of plasminogen activation  
involved_in positive regulation of extracellular matrix constituent secretion  
involved_in protein catabolic process  
involved_in proteolysis  
involved_in response to xenobiotic stimulus  
Component Evidence Code Pubs
located_in extracellular exosome PubMed 
located_in extracellular region  
is_active_in extracellular space  

General protein information

Preferred Names
carboxypeptidase B2
Names
carboxypeptidase B-like protein
carboxypeptidase B2 (plasma)
carboxypeptidase B2 (plasma, carboxypeptidase U)
carboxypeptidase R
thrombin-activable fibrinolysis inhibitor
thrombin-activatable fibrinolysis inhibitor
NP_001265470.1
NP_001863.3
XP_016875882.1
XP_054230089.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032893.2 RefSeqGene

    Range
    5001..56848
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_632

mRNA and Protein(s)

  1. NM_001278541.2NP_001265470.1  carboxypeptidase B2 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_001265470.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
    Source sequence(s)
    AB011969, AL137141, AL157758, AU100156
    Consensus CDS
    CCDS73568.1
    UniProtKB/TrEMBL
    A0A087WSY5
    Related
    ENSP00000400714.3, ENST00000439329.5
    Conserved Domains (2) summary
    pfam02244
    Location:33104
    Propep_M14; Carboxypeptidase activation peptide
    cl11393
    Location:119383
    Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
  2. NM_001872.5NP_001863.3  carboxypeptidase B2 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_001863.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AL137141, AL157758, BC007057
    Consensus CDS
    CCDS9401.1
    UniProtKB/Swiss-Prot
    A8K464, Q15114, Q5T9K1, Q5T9K2, Q96IY4, Q9P2Y6
    Related
    ENSP00000181383.4, ENST00000181383.10
    Conserved Domains (2) summary
    cd06246
    Location:119420
    M14_CPB2; Peptidase M14 carboxypeptidase subfamily A/B-like; Carboxypeptidase B2 subgroup
    pfam02244
    Location:33104
    Propep_M14; Carboxypeptidase activation peptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

    Range
    46053186..46105033 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020393.3XP_016875882.1  carboxypeptidase B2 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060937.1 Alternate T2T-CHM13v2.0

    Range
    45274576..45326411 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054374114.1XP_054230089.1  carboxypeptidase B2 isoform X1

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