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Efnb2 ephrin B2 [ Mus musculus (house mouse) ]

Gene ID: 13642, updated on 4-Jan-2025

Summary

Official Symbol
Efnb2provided by MGI
Official Full Name
ephrin B2provided by MGI
Primary source
MGI:MGI:105097
See related
Ensembl:ENSMUSG00000001300 AllianceGenome:MGI:105097
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Epl5; ELF-2; Eplg5; Htk-L; Lerk5; LERK-5; NLERK-1
Summary
Enables signaling receptor binding activity. Involved in several processes, including adherens junction organization; positive regulation of cardiac muscle cell differentiation; and regulation of postsynaptic neurotransmitter receptor internalization. Acts upstream of or within several processes, including negative regulation of keratinocyte proliferation; positive regulation of aorta morphogenesis; and vasculature development. Located in plasma membrane. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; cardiovascular system; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in colon carcinoma; colorectal carcinoma; and esophagus squamous cell carcinoma. Orthologous to human EFNB2 (ephrin B2). [provided by Alliance of Genome Resources, Jan 2025]
Expression
Broad expression in lung adult (RPKM 20.3), colon adult (RPKM 11.2) and 23 other tissues See more
Orthologs
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Genomic context

See Efnb2 in Genome Data Viewer
Location:
8 A1.1; 8 3.42 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (8667235..8711242, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (8617235..8661242, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 31135 Neighboring gene peroxiredoxin 3 pseudogene Neighboring gene VISTA enhancer mm985 Neighboring gene STARR-seq mESC enhancer starr_20661 Neighboring gene predicted gene, 31463 Neighboring gene STARR-seq mESC enhancer starr_20662 Neighboring gene RIKEN cDNA 4921522P10 gene Neighboring gene arginine and glutamate rich 1 Neighboring gene microRNA 7654

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 
  • Targeted (20)  1 citation

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ephrin receptor binding  
enables ephrin receptor binding  
enables ephrin receptor binding  
enables protein binding PubMed 
enables signaling receptor binding PubMed 
Items 1 - 25 of 35
Process Evidence Code Pubs
acts_upstream_of_or_within T cell costimulation PubMed 
involved_in adherens junction organization PubMed 
acts_upstream_of_or_within animal organ morphogenesis PubMed 
involved_in axon guidance  
involved_in blood vessel morphogenesis  
acts_upstream_of_or_within blood vessel morphogenesis PubMed 
involved_in cell adhesion  
involved_in cell adhesion  
involved_in cell differentiation  
involved_in cell migration involved in sprouting angiogenesis  
involved_in cell migration involved in sprouting angiogenesis  
involved_in cellular response to lipopolysaccharide  
involved_in ephrin receptor signaling pathway  
involved_in ephrin receptor signaling pathway  
involved_in ephrin receptor signaling pathway  
acts_upstream_of keratinocyte proliferation PubMed 
acts_upstream_of_or_within lymph vessel development PubMed 
acts_upstream_of_or_within negative regulation of keratinocyte proliferation PubMed 
involved_in negative regulation of neuron projection development  
involved_in negative regulation of neuron projection development  
acts_upstream_of_or_within nephric duct morphogenesis PubMed 
acts_upstream_of_or_within positive regulation of aorta morphogenesis PubMed 
involved_in positive regulation of cardiac muscle cell differentiation PubMed 
involved_in positive regulation of cell population proliferation  
involved_in positive regulation of cell population proliferation  
involved_in presynapse assembly  
involved_in presynapse assembly  
involved_in regulation of chemotaxis  
involved_in regulation of chemotaxis  
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
involved_in regulation of postsynaptic membrane neurotransmitter receptor levels PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
involved_in regulation of postsynaptic neurotransmitter receptor internalization PubMed 
acts_upstream_of_or_within venous blood vessel morphogenesis PubMed 
Items 1 - 25 of 35
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse PubMed 
is_active_in Schaffer collateral - CA1 synapse PubMed 
located_in adherens junction  
located_in dendrite  
located_in dendrite  
is_active_in glutamatergic synapse  
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse PubMed 
is_active_in glutamatergic synapse  
is_active_in plasma membrane  
located_in plasma membrane PubMed 
located_in plasma membrane  
located_in plasma membrane  
is_active_in postsynaptic density membrane PubMed 
is_active_in presynaptic membrane  
located_in presynaptic membrane  
is_active_in presynaptic membrane  

General protein information

Preferred Names
ephrin-B2
Names
EPH-related receptor tyrosine kinase ligand 5
HTK ligand

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001368299.1NP_001355228.1  ephrin-B2 isoform 2 precursor

    Status: VALIDATED

    Source sequence(s)
    AC138368, AC161867
  2. NM_010111.6NP_034241.2  ephrin-B2 isoform 1 precursor

    See identical proteins and their annotated locations for NP_034241.2

    Status: VALIDATED

    Source sequence(s)
    AC138368, AC161867
    Consensus CDS
    CCDS22090.1
    UniProtKB/Swiss-Prot
    P52800
    UniProtKB/TrEMBL
    Q3V1E0, Q4FJM3
    Related
    ENSMUSP00000001319.8, ENSMUST00000001319.15
    Conserved Domains (1) summary
    cd10426
    Location:32168
    Ephrin-B_Ectodomain; Ectodomain of Ephrin B

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    8667235..8711242 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242036.3XP_011240338.1  ephrin-B2 isoform X1

    Conserved Domains (1) summary
    cd10426
    Location:44168
    Ephrin-B_Ectodomain; Ectodomain of Ephrin B
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