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ADORA3 adenosine A3 receptor [ Homo sapiens (human) ]

Gene ID: 140, updated on 4-Jan-2025

Summary

Official Symbol
ADORA3provided by HGNC
Official Full Name
adenosine A3 receptorprovided by HGNC
Primary source
HGNC:HGNC:268
See related
Ensembl:ENSG00000282608 MIM:600445; AllianceGenome:HGNC:268
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
A3AR
Summary
This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]
Expression
Broad expression in adrenal (RPKM 4.4), small intestine (RPKM 2.9) and 20 other tissues See more
Orthologs
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Genomic context

See ADORA3 in Genome Data Viewer
Location:
1p13.2
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (111499429..111503633, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (111514110..111518318, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (112042051..112046255, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene chromosome 1 open reading frame 162 Neighboring gene RNA, U6 small nuclear 792, pseudogene Neighboring gene transmembrane and immunoglobulin domain containing 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1498 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1499 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1500 Neighboring gene RAP1A, member of RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1501 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1502 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1503 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1504 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1505 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1506 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:112150779-112151472 Neighboring gene long intergenic non-protein coding RNA 1160 Neighboring gene uncharacterized LOC107985184 Neighboring gene Sharpr-MPRA regulatory region 155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1186

Genomic regions, transcripts, and products

Expression

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of adenosine A3 receptor (ADORA3) in peptide-treated PBMCs PubMed
Tat tat HIV-1 Tat upregulates adenosine A3 receptor in HEK 293T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in Schaffer collateral - CA1 synapse  
is_active_in dendrite  
is_active_in plasma membrane  
located_in plasma membrane  
located_in presynaptic membrane  
is_active_in synapse  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032119.1 RefSeqGene

    Range
    5001..85628
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_424

mRNA and Protein(s)

  1. NM_000677.4NP_000668.1  adenosine receptor A3 isoform A

    See identical proteins and their annotated locations for NP_000668.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (A) encodes the longest isoform (A).
    Source sequence(s)
    AL390195
    Consensus CDS
    CCDS839.1
    UniProtKB/Swiss-Prot
    A2A3P4, P0DMS8, P33765, Q6UWU0, Q9BYZ1
    UniProtKB/TrEMBL
    B2R7S2, H6VQ59
    Related
    ENSP00000241356.4, ENST00000241356.5
    Conserved Domains (2) summary
    cd14964
    Location:1539
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:13293
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  2. NM_001302678.2NP_001289607.1  adenosine receptor A3 isoform B

    Status: REVIEWED

    Description
    Transcript Variant: This variant (B) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region and 3' UTR, compared to variant A. The encoded isoform (B) has a distinct C-terminus and is shorter than isoform A.
    Source sequence(s)
    AL390195, BF432324, BM675096, CD013875, JN855714
    Consensus CDS
    CCDS81358.1
    UniProtKB/TrEMBL
    A0A0J9YWR0
    Related
    ENSP00000488073.1, ENST00000632535.1
    Conserved Domains (2) summary
    cd14964
    Location:1440
    7tm_GPCRs; TM helix 1 [structural motif]
    cl28897
    Location:13116
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily
  3. NM_001302679.2NP_001289608.1  adenosine receptor A3 isoform C

    Status: REVIEWED

    Description
    Transcript Variant: This variant (C) uses an alternate splice site in the 5' terminal exon, and it thus differs in its 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant A. The encoded isoform (C) is shorter at the N-terminus, compared to isoform A.
    Source sequence(s)
    AL390195, BF432324, BM675096, BX283401, JN855714
    UniProtKB/TrEMBL
    H6VQ59
    Conserved Domains (2) summary
    cd14964
    Location:2959
    7tm_GPCRs; TM helix 5 [structural motif]
    cl28897
    Location:1148
    7tm_GPCRs; seven-transmembrane G protein-coupled receptor superfamily

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    111499429..111503633 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    111514110..111518318 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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